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Faculty Information

Seiichi Yamano, DDS, PhD, DMD, MMSc
Assistant Professor
Prosthodontics
Floor 16N Dental Center, 421 First Avenue
E-mail:

 

Education:

1990, DDS, Nihon University, Japan

1994, PhD, Tokyo Medical University, Japan

1997-2002, Postdoc, National Institutes of Health

2004, DMD, University of Pennsylvania

2007, MMSc, Harvard University

2007, Certificate in Prosthodontics, Harvard University

 

Research Interests / Professional Overview:

Dr. Yamano conducts translational research as a clinician/scientist. The long-term goal of his research program is that his studies will benefit patients with advanced prosthodontic treatment needs. Currently, Dr. Yamano’s lab investigates 3 major areas: (1) utilization of efficient non-viral vectors for gene therapy, (2) growth factor protein delivery using collagen membranes for bone regeneration, and (3) molecular analysis of osseointegration for novel implant surfaces. Recently, his lab has demonstrated that combining modified HIV-1 Tat peptide with cationic lipids or polymers dramatically enhanced transfection efficiency without any associated toxicity in vitro and in vivo. Using these novel gene vectors, his lab is investigating whether cancer-induced pain is attenuated by re-expression of the methylated µ-opioid receptor gene. This project is conducted in collaboration with Dr. Brain Schmidt at NYUCD. In addition, his group reported the ability of a collagen membrane to successfully deliver sustained release of growth/differentiation factor 5 and the subsequent osteogenic effects of the released factor on bone regeneration compared to platelet-derived growth factor. Also, Dr. Yamano’s lab is working in collaboration with Dr. Jin Montclare at NYU Polytechnic School of Engineering to exam the mechanism of action in terms of curcumin delivery and killing ability on cancer cells using novel engineered protein polymer.

 

Current Funding:

American College of Prosthodontists Education Foundation – Young Prosthodontist Innovator Award

American College of Prosthodontists Education Foundation – Research Fellowship Award

Academy of Prosthodontics – Research Award  

Northeastern Gnathological Society Granger – Pruden Memorial Award

 

Pub Med Articles:

Yamano S

 

Representative Publications:

Yamano, S., Haku, K., Yamanaka, T., Dai, J., Takayama, T., Shohara, R., Tachi, K., Ishioka, M., Hanatani, S., Karunagaran, S., Wada, K., and Moursi, A.M. The effect of a bioactive collagen membrane releasing PDGF or GDF-5 on bone regeneration. Biomaterials 35: 2446-2453, 2014.

Yamano, S., Dai, J., Hanatani, S., Haku, K., Yamanaka, T., Ishioka, M., Takayama, T., Yuvienco, C., Khapli, S., Moursi, A.M., and Montclare, J.K. Long-term efficient gene delivery using polyethylenimine with modified Tat peptide. Biomaterials 35: 1707-1715, 2014.

Keswani, S.G., Balaji, S., Le, L.D., Leung, A., Parvadia, J.K., Frischer, J., Yamano, S., Taichman, N., and Crombleholme, T.M. Role of salivary vascular endothelial growth factor (VEGF) in palatal mucosal wound healing. Wound Repair Regen. 21: 554-562, 2013.

Yamano, S., Kuo, W.P., and Sukotjo, C. Downregulated gene expression of TGF-bs in diabetic oral wound healing. J. Craniomaxillofac. Surg. 41: e42-e48, 2013.

Yamano, S., Haku, K., Ishioka, M., Lin, T.Y., Hanatani, S., Dai, J., and Moursi, A.M. The potential of tissue engineering and regeneration for craniofacial bone. Dentistry 2: 136, 2012.

Yamano, S., Lin, T.Y., Dai, J., Fabella, K., and Moursi, A.M. Bioactive collagen membrane as a carrier of sustained release of PDGF. J. Tissue Sci. Eng. 2: 110, 2011.

Tsukinoki, K., Saruta, J., Yamano, S., and Tomita, M. The salivary gland and systemic health: towards the creation of salivary gland and health medicine. J. Oral Biosci. 53: 330-337, 2011.

Yamano, S., Ma, A.K., Shanti, R.M., Kim, S.W., Wada, K., and Sukotjo, C. The influence of different implant material on human gingival fibroblast morphology, proliferation, and gene expression. Int. J. Oral Maxillofac. Implants 26: 1247-1255, 2011.

Yamano, S., Al-Sowygh, Z.H., Gallucci, G.O., Wada, K., Weber, H.P., and Sukotjo, C. Early peri-implant tissue reactions on different titanium surface topographies. Clin. Oral Implants Res. 22: 815-819, 2011.

Yamano, S., Dai, J., Yuvienco, C., Khapli, S., Moursi, A.M., and Montclare, J.K. Modified Tat peptide with cationic lipids enhances gene transfection efficiency via temperature-dependent and caveolae-mediated endocytosis. J. Control. Release 152: 278-285, 2011.

Yamano, S., Berley, J.A., Kuo, W.P., Gallucci, G.O., Weber, H.P., and Sukotjo, C. Effects of nicotine on gene expression and osseointegration in rats. Clin. Oral Implants Res. 21: 1353-1359, 2010.

Yamano, S., Dai, J., and Moursi, A.M. Comparison of transfection efficiency of nonviral gene transfer reagents. Mol. Biotechnol. 46: 287-300, 2010.

Berley, J., Yamano, S., and Sukotjo, C. The effect of systemic nicotine on osseointegration of titanium implants in the rat femur. J. Oral Implantol. 36: 185-193, 2010.

Yamano, S., Nissenbaum, M., Dodson, T.B., Gallucci, G.O., and Sukotjo, C. Multidisciplinary treatment for a young patient with severe maxillofacial trauma from a snowmobile accident: a case report. J. Oral Implantol. 36: 141-143, 2010.