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Faculty Information

Simone Duarte, DDS, MS, PhD
Assistant Professor
Basic Science and Craniofacial Biology
Room 921C Schwartz Hall, 345 East 24Th Street
Fax: 212-995-4087
E-mail:

 

Education:

2000, DDS, Dental School of Piracicaba – FOP/UNICAMP, Brazil
2002, MS – Pharmacology, Dental School of Piracicaba – FOP/UNICAMP, Brazil
2003-2004, Visiting Scholar, Center for Oral Biology, University of Rochester, USA
2005, Ph.D. – Pharmacology, Dental School of Piracicaba – FOP/UNICAMP, Brazil
2005-2007, Post-doctoral, Eastman Dental Center, University of Rochester, USA

 

Research Interests / Professional Overview:


* Microbial Biofilms
* Biofilm matrix - structural and physical properties
* Natural compounds
* Effect of Microgravity on microbial biofilms

Dr. Simone Duarte is Assistant Professor in the Department of Basic Science and Craniofacial Biology and the course director of Pharmacology at the College of Dentistry. Dr. Duarte’s research focuses on the understanding and control of cariogenic dental biofilms using natural agents. She is working together with Dr. David Grier, from the department of Physics and Center for Soft Matter Reseach at New York University, trying to establish a new methodology to analyze the physical properties of dental biofilms, using holographic microrheology. This new methodology is very unique and shows promise for high-throughput combinatorial screening of candidate therapeutic or remedial agents. In addition, Dr. Duarte’s lab also studies the structural characterization of the biofilm matrix, using Confocal Laser Scanning Microscopy (CLSM); quantifying the structural properties by analyzing the CLSM images using COMSTAT software (Heydorn et al., 2000). Rather than assessing their biological or biochemical influence, holographic microrheology together with CLSM offers direct insight into these agents influence on biofilm matrix’s structure and physical properties.

Her lab is also working together with Dr. Thais Russomano, from the Microgravity Centre/FENG-PUCRS group, in Brazil, and with Dr. Grier and Dr. Deepak Saxena, from NYU, determining the influence of microgravity on the microbial biofilm matrix, based on the hypothesis that there is an increased pathogenicity of biofilms formed under microgravity related to a change in their extracellular polysaccharide matrix. This innovative methodology is used to identify novel targets for prevention and treatment of infectious diseases associated with biofilms formed in situ during space travel

 

Representative Publications:

Klein MI, Duarte S, Xiao J, Mitra S, Foster TH, Koo H. Structural and molecular basis of the role of starch and sucrose in Streptococcus mutans biofilms development. Journal of Antimicrobial Chemotherapy. 2008 (submitted for publication)

Cheong FC, Duarte S, Lee S, Grier DG. Holographic microrheology of polysaccharides from Streptococcus mutans biofilms, Rheologica Acta. 2008 (in press).

Aires CP, Del Bel Cury AA, Tenuta LMA, Klein MI, Koo H, Duarte S, Cury JA. Effect of starch and sucrose on dental biofilm formation and on root dentine demineralization. Caries Res. 2008 Sep 10;42(5):380-386.

Duarte S, Klein MI, Aires CP, Cury JA, Bowen WH, Koo H. Influences of starch and sucrose on Streptococcus mutans biofilms. Oral Microbiol Immunol. 2008 Jun;23(3):206-12.

Duarte S, Gregoire S, Singh AP, Vorsa N, Schaich K, Bowen WH, Koo H. Inhibitory effects of cranberry polyphenols on formation and acidogenicity of Streptococcus mutans biofilms. FEMS Microbiol Lett. 2006 Apr;257(1):50-6.

Duarte S, Rosalen PL, Hayacibara MF, Cury JA, Bowen WH, Marquis RE, Rehder VL, Sartoratto A, Ikegaki M, Koo H. The influence of a novel propolis on mutans streptococci biofilms and caries development in rats. Arch Oral Biol. 2006 Jan;51(1):15-22. Epub 2005 Jul 28.

Hayacibara MF, Koo H, Rosalen PL, Duarte S, Franco EM, Bowen WH, Ikegaki M, Cury JA. In vitro and in vivo effects of isolated fractions of Brazilian propolis on caries development. J Ethnopharmacol. 2005 Oct 3;101(1-3):110-5.

Duarte S, Koo H, Bowen WH, Hayacibara MF, Cury JA, Ikegaki M, Rosalen PL. Effect of a novel type of propolis and its chemical fractions on glucosyltransferases and on growth and adherence of mutans streptococci. Biol Pharm Bull. 2003 Apr;26(4):527-31.


Representative Awards:


AADR/Pfizer Hatton – 2nd place – American Division of the International association for dental research (IADR) - 2008
KLEIN MI, DUARTE S, and KOO H. Role of starch and sucrose in Streptococcus mutans biofilms formation. University of Rochester School of Medicine and Dentistry, NY, USA

AADR/Pfizer Hatton – 3rd place – American Division of the International association for dental research (IADR) - 2007
DUARTE S, CURY JA, BOWEN WH, and KOO H. Influence of starch and sucrose on Streptococcus mutans biofilms. University of Rochester School of Medicine and Dentistry, NY, USA; FOP/UNICAMP, Piracicaba, Brazil.

SBPqO/Pfizer Hatton – 1st place – Brazilian Division of the International association for dental research (IADR) - 2004
DUARTE S, ROSALEN PL, CURY JA, SCHOBEL B, GUZMÁN PN, BOWEN WH, KOO H. Influence of cranberry on virulence factors associated with the pathogenesis of dental caries. Pesquisa Odontológica Brasileira, v.18, p.18, São Paulo, SP, 2004 [H-011]

1st Place of the research group award in the 21st Annual meeting of the SBPqO (Brazilian Division of the International association for dental research (IADR)
DUARTE S, ROSALEN PL, CURY JA, REHDER VG, SARTORATTO A, IKEGAKI M, BOWEN WH, KOO H. Efeito das frações bioativas da própolis tipo-6 na atividade das glucosiltransferases e na formação do biofilme. [Effect of propolis type-6 fraction on glucosyltransferase activity and on biofilm formation] Pesquisa Odontológica Brasileira, v.18, p. 213, São Paulo, SP, 2004 [Pc-086]

1st Place of the research group award in the 20th Annual meeting of the SBPqO (Brazilian Division of the International association for dental research (IADR)
DUARTE S, HAYACIBARA MF, IKEGAKI M, REHDER VG, BOWEN WH, CURY JA, KOO H, ROSALEN PL. Composição química e efeito anticárie da própolis tipo 6. [Chemical composition and anti-caries effect of propolis type-6] Pesquisa Odontológica Brasileira, v.17, p.174, São Paulo, SP, 2003 [Pb-126]

1st Place of the research group award in the 19th Annual meeting of the SBPqO (Brazilian Division of the International association for dental research (IADR)
FRANCO EM, DUARTE S, ROSALEN PL, CURY JA. Avaliação de uma formulação estabilizada de dentifrício contendo NaF/CaCO3, em modelo animal de cárie experimental. [Evaluation of a stabilized formulation of dental paste containing NaF/CaCO3 in dental caries using animal model] Pesquisa Odontológica Brasileira, v.16, p.225, São Paulo, SP, 2002 [Pc-077]