New York University - College of Dentistry
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Faculty Information

Robert M. Davidson, D.D.S., Ph.D.
Associate Professor
Periodontology and Implant Dentistry
Room 413 Dental Center, 421 First Avenue
Fax: 212-995-4087
E-mail:

 

Education:

1965 B.A., Drew University
1971 D.D.S., Fairleigh Dickinson University
1986 Certificate Periodontics, SUNY at Buffalo
1988 Ph.D., State University NY at Buffalo

 

Research Interests / Professional Overview:

  • Physiology and immunohistochemistry of dental pulp.
  • Cation regulation of the osteoclast cell.

Ion Channel Properties of Mineralogenic Cells
One area of interest in our laboratory focuses on the ionic mechanisms that regulate activity of mineralogenic cells in bones and teeth. Specifically, we are interested in the physiological and kinetic properties of cation channels in osteoclast and osteoblast cells found in bone, as well as odontoblast cells from dental pulp. A second area of interest focuses on the immunohistochemical and physiological properties of dental pulp cells and their relation to sensory transduction in teeth. In particular, we are interested in the voltage-gated sodium channel found in the non-odontoblast dental pulp cell. We use a combination of patch-clamp recording techniques, fluorometric imaging, and immunohistochemistry.

Dr. Robert Davidson joined the faculty at NYUCD in 1996, and was appointed the Chairman of the Department of Periodontics in 2000. Dr. Davidson's general research interests have focused on the ionic mechanisms that regulate activity of mineral-producing cells in bones and teeth. More specifically, he has studied the physiological and kinetic properties of cation channels in osteoclast and osteoblast cells found in bone, as well as odontoblast cells from dental pulp.

A second area of his interests has focused on the immunohistochemical and physiological properties of dental pulp cells and their relation to sensory transduction in teeth. His teaching areas include Periodontal Diagnostics, Pathogenesis and Treatment Planning, and Therapeutics, and most recently, he has developed an interest in the application of E-learning to these disciplines in the dental school curriculum.

 

Pub Med Articles:

Davidson RM

 

Representative Publications:


Davidson, R.M. Membrane stretch activates a Ca2+-dependent high-conductance K+ channel in osteoblast-like cells. J. Memb. Biol., 131 (1993):81-92.

Davidson, R.M. Potassium currents in cells derived from human dental pulp. Arch. Oral Biol., 38 (1993):803-811.

Davidson, R.M. Neural form of voltage-dependent sodium current in human cultured dental pulp cells. Arch. Oral Biol., 39 (1994):613-620.

Gofa A, Davidson R.M. NaF potentiates a K+-selective ion channel in G292 osteoblastic cells. J. Memb. Biol., 149 (1996):211-219.

Davidson, R.M, Lingenbrink, P.A., Norton, L.A. Continuous mechanical loading alters properties of mechanosensitive channels in G292 osteoblastic cells. Calicif. Tissue Inter., 59 (1996):500-504.

Zhang J, Loew LM, Davidson R.M. Faster voltage-dependent activation of Na+ channels in growth cones versus somata of neuroblastoma N1E-115 cells. Biophysical J., 71 (1996):2501-8.

Zhang, J., Davidson, R.M., Wei, M., Loew, L.M. Membrane electric properties by combined patch clamp and fluorescence ratio imaging in single neurons. Biophys. J., 74 (1998):48-53.

Guo, L. and Davidson, R.M. (1999) Potassium and chloride channels in freshly isolated rat odontoblasts. J. Dent. Res., 77 (1998):341-50.

Guo L. Davidson R.M. Extracellular Ca2+ increases cytosolic free Ca2+ in freshly isolated rat odontoblasts. J. Bone Mineral Res.,14 (1999):1357-66.

Guo L. Berry JE. Somerman MJ. Davidson R.M. A novel method to isolate odontoblasts from rat incisor. Calc. Tiss.Int., 66 (2000):212-6.