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Faculty Information

Nicola C Partridge, Ph.D.
Professor, Chairperson
Basic Science and Craniofacial Biology
Room 902A Schwartz Hall, 345 East 24Th Street
Fax: 212-995-4204
E-mail:

 

Education:

1973    B.Sc. (Hons)   University of Western Australia, Australia
1981    Ph.D.               University of Western Australia, Australia

 

Research Interests / Professional Overview:

Dr. Partridge's research focuses on parathyroid hormone (PTH) regulation of gene expression by the osteoblast.  In one project, her laboratory is investigating how PTH, acting through protein kinase A (PKA), signals to nuclear chromatin of the osteoblast and causes co-repressor proteins (e.g. histone deacetylases) to dissociate from,  and co-activator proteins (e.g. histone acetyltransferases) to associate with a gene.  Matrix metalloproteinase-13 (MMP-13, collagenase-3) is the gene under investigation.  In a second project, Dr. Partridge's laboratory is examining how PTH has its anabolic effects on bone.  They have found that the gene most highly regulated by PTH in an anabolic (daily injection) protocol is monocyte chemoattractant protein-1 (MCP-1).  Her laboratory has shown that the anabolic effect of PTH is abolished in MCP-1 null mice.  In addition, PTH is unable to recruit osteoclasts in these mice.  They have concluded that PTH acts via MCP-1 to stimulate osteoclasts which are then necessary for PTH's anabolic effects.  Other projects involve examination of Wnt-4 effects on mesenchymal stem cells and osteoblasts, and how pulsed electromagnetic fields act on osteoblasts.

 

Current Funding:

Nuclear Events in PTH Action on Bone - NIDDK

Pulsed Electromagnetic Field on Osteogenesis- Orthofix, Inc.

 

Pub Med Articles:

Partridge NC

 

Representative Publications:

Selvamurugan, N., Kwok, S., Jefcoat, Jr.,  S.C., Vasilov, A. and Partridge, N.C. Effects of BMP-2 and pulsed electromagnetic field (PEMF) on rat primary osteoblastic cell proliferation and gene expression. J. Ortho. Res., 25, 1213-1220, 2007.

Zhu J., Jia, X., Xiao G., Kang, Y., Partridge, N.C. and Qin, L. EGF-like ligands stimulate osteoclastogenesis by regulating expression of osteoclast regulatory factors by osteoblasts: implications for osteolytic bone metastases. J. Biol. Chem., 282, 26656-26664, 2007.

Li., X., Liu, H., Qin, L., Tamasi, J., Bergenstock, M., Shapses, S., Feyen, J.H.M., Notterman, D.A., and Partridge, N.C. Determination of parathyroid hormone's dual effects on skeletal gene expression in vivo by microarray and network analysis. J. Biol. Chem., 282, 33086-33097, 2007.

Li, X., Qin, L., Bergenstock, M., Bevelock, L.M., Novack, D.V. and Partridge, N.C. Parathyroid hormone stimulates osteoblastic expression of MCP-1 to recruit and increase the fusion of pre/osteoclasts. J. Biol. Chem., 282, 33098-33106, 2007.

Shimizu, E., Selvamurugan, N., Westendorf, J.J. and Partridge, N.C. Parathyroid hormone regulates histone deacetylases in osteoblasts. Ann. N.Y. Acad. Sci. 1116, 349-353, 2007.

Bergenstock, M.K. and Partridge, N.C. Parathyroid hormone stimulation of noncanonical Wnt signaling in bone. Ann. N.Y. Acad. Sci. 1116, 354-359, 2007.

Raggatt, L.J., Qin, L., Tamasi, J., Jefcoat, S.C., Jr., Liew, F.Y., Bevelock, L., Shimizu, E., Selvamurugan, N., Feyen, J.H.M. and Partridge, N.C. IL-18 is regulated by parathyroid hormone and is required for its bone-anabolic actions. J. Biol. Chem., 283, 6790-6798, 2008.

Li, X., Qin, L. and Partridge. N.C. In vivo PTH treatments and RNA isolation/analysis. Invited chapter in "Osteoporosis-Methods in Molecular Medicine" (ed. J.J. Westendorf), Humana Press, Totowa, 79-87, 2008.

Cheeseman, C. and Partridge, N.C. Association of Chairs of Departments of Physiology 2007 survey results. The Physiologist 51, 87-93, 2008.

Qin, L., Qiu P. and Partridge, N.C. Gene expression profiles and transcription factors involved in parathyroid hormone signaling in osteoblastic cells.  Invited chapter in "Genomics in Endocrinology: DNA Microarray Analysis of Endocrine Cells in Health and Disease" (eds. S. Handwerger and B.J. Aronow), Humana Press, Totowa, 25-39, 2008.

Lee, M., Shimizu, E., Krane, S.M. and Partridge, N.C. Bone Proteinases. In "Principles of Bone Biology" (eds. J.P. Bilizekian and L.G. Raisz) Academic Press, San Diego, 3rd edition, pp. 367-384, 2008.

Sukumar, D., Shapses, S., Partridge, N.C. and Schneider, S. Intervariability among serum intact parathyroid hormone assays: a need for standardization. Osteoporosis Int., 19, 1805-1806, 2008.

Kwok, S., Partridge, N.C., Srinivasan, N., Nair, S.V. and Selvamurugan, N. Mitogen activated protein kinase-dependent inhibition of osteocalcin gene expression by transforming growth factor-ß1. J. Cell. Biochem., 106, 161-169, 2009.

Selvamurugan, N., Shimizu, E., Lee, M., Liu, T., Li, H. and Partridge, N.C. Identification and characterization of Runx2 phosphorylation sites involved in matrix metalloproteinase-13 promoter activation.  FEBS Lett., 583, 1141-1146, 2009.

Lee, M. and Partridge, N.C. Parathyroid hormone signaling in bone and kidney. Current Opinion in Nephrology and Hypertension, 18, 298-302, 2009. PMID: 19423655

Boumah, C.E., Lee, M., Selvamurugan, N., Shimizu, E. and Partridge, N.C. Runx2 recruits p300 to mediate parathyroid hormone's effects on histone acetylation and transcriptional activation of the matrix metalloproteinase-13 gene. Mol. Endo., 23, 1255-1263, 2009. PMID: 19423655

Tutak W., Park K.H., Vasilov A., Starovoytov V., Fanchini G., Cai S.-Q., Partridge, N.C., Sesti, F. and Chhowalla M. Toxicity induced enhanced extracellular matrix production in osteoblastic cells cultured on single walled carbon nanotube networks. Nanotechnology, 20, 255101, 2009. PMID: 19487801

Kwok, S., Rittling, S., Partridge, N., Benson, S., Thiyagaraj, M., Narasaimhan, S., Selvamurugan, N. Transforming growth factor-β1 regulation of ATF-3 and identification of ATF-3 target genes in breast cancer cells. J. Cell. Biochem., 108, 408-414, 2009. PMID: 19582787

Shimizu, E., Selvamurugan, N., Westendorf, J.J., Olson, E.N.  and Partridge, N.C. Histone deacetylase 4 represses matrix metalloproteinase-13 transcription in osteoblastic cells and parathyroid hormone controls this repression. J. Biol. Chem., 285, 9616-9626, 2010. PMID: 20097749.

Raggatt, L.J. and Partridge N.C. Cellular and molecular mechanisms of bone remodeling. J. Biol. Chem., Invited Mini-review, 285, 25103-25108, 2010. PMID: 2919071

Sahithi, K., Swetha, M., Prabaharan, M., Moorthi, A., Saranya, N., Ramasamy, K., Srinivasan, N., Partridge, N.C. and Selvamurugan, N. Synthesis and characterization of nanoscale-hydroxyapatite-copper for antimicrobial activity towards bone tissue engineering applications. J. Biomed. Nanotechnology, 6, 1-7, 2010.

Lee, M. and Partridge, N.C. Parathyroid hormone activation of matrix metalloproteinase-13 transcription requires the histone acetyltransferase activity of p300 and PCAF and p300-acetylation of PCAF. J. Biol. Chem., 285, 38014-38022, 2010.

Sukumar, D., Partridge, N.C., Wang, X. and Shapses, S.A. The high serum monocyte chemoattractant protein-1 in obesity is influenced by high serum parathyroid hormone and not adiposity. J. Clin. Endo. Metab., 96, 1852-1858, 2011. PMID:21508136

 Zhang, X., Tamasi, J., Lu, X., Zhu, X., Chen, H.,  Tian, X., Lee, T.-C., Threadgill, D.W., Kream, B.E., Kang, Y., Partridge, N.C. and Qin, L. Epidermal growth factor receptor plays an anabolic role in bone metabolism in vivo. J. Bone Min. Res., 26, 1022-1034, 2011. PMID: 21542005

Zhu, J., Shimizu, E., Zhang, X., Partridge, N.C. and Qin, L. EGFR signaling suppresses osteoblast differentiation and inhibits expression of master osteoblastic transcription factors Runx2 and Osterix. J. Cell. Biochem., 112, 1749-1760, 2011. PMID:21381079

Tripathi, A., Saravanan, S., Pattnaik, S., Moorthi, A., Partridge, N.C., Selvamurugan, N.  Bio-composite scaffolds containing chitosan/nano-hydroxyapatite/nano-copper-zinc for bone tissue engineering. Int. J. Biol. Macromol., 50, 294-299, 2012. PMID:22123094

Shimizu, E., Tamasi, J. and Partridge, N.C. Alendronate affects osteoblast functions by crosstalk through ephrinB1-EphB.  J. Dent. Res., 91, 268-74, 2012. PMID:22180568

Moorthi, A., Saravanan, S., Srinivasan, N., Partridge, N.C., Zhu, J., Qin,L. and Selvamurugan, N. Synthesis, characterization and biological action of nano-bioglass ceramic particles for bone formation. J. Biomaterials Tiss. Engineering 2, 197–205, 2012.

Qin, L. and Partridge, N.C. Parathyroid hormone and parathyroid hormone-related protein: normal function, diseases and emerging therapeutics. In “Bone-Metabolic Functions and Modulators” (Topics in Bone Biology Series Vol. 7, eds. F. Bronner, M.C. Farach-Carson and H.I. Roach), Springer-Verlag, London, pp. 1-19, 2012.

Barnes, V.M., Xu, T., Shimizu, E., Jefcoat, S., Jr., Vasilov, A., Qin, L. and Partridge, N.C. Triclosan reduces the expression of MMP-13 in hormone-stimulated osteoblasts. J. Periodontol., in press, 2013.