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Faculty Information

Brian Schmidt, DDS, MD, PhD
Director, Bluestone Center for Clinical Research
Professor

Oral and Maxillofacial Surgery
Floor 2W Dental Center, 421 First Avenue
Fax: 212-995-4843
E-mail:

 

Education:

1988 B.S., University of California, Davis, Biochemistry
1992 D.D.S., University of California, San Francisco
1996 M.D., University of California, San Francisco
2001 Ph.D., University of California, San Francisco, Oral Biology

 

Research Interests / Professional Overview:

Dr. Schmidt is a clinician scientist and surgical oncologist who specializes in the comprehensive surgical management of head and neck cancer. His research interests and clinical practice are closely integrated. His basic science laboratory focuses on neuronal mechanisms of cancer pain including the interaction between squamous cell carcinoma and peripheral afferent fibers in the cancer microenvironment. His clinical research program investigates biomarkers of oral cancer.

 

Current Funding:

National Institute of Health

 

Pub Med Articles:

Schmidt BL

 

Representative Publications:

Dolan JC, Lam DK, Achdjian SH, Schmidt BL. The Dolognawmeter: A Novel Instrument and Assay to Quantify Nociception in Rodent Models of Orofacial Pain.  J Neurosci Methods, 2010;187:207-15.  PMCID: PMC2832714  

Lam DK, Schmidt BL.  Serine proteases and protease-activated receptor 2-dependent allodynia: A novel cancer pain pathway.  Pain, 2010; 149(2):263-72.  PMCID: PMC2861734

Quang P, Schmidt BL.  Peripheral endothelin B receptor agonist-induced antinociception involves endogenous opioids in mice.  Pain. 2010 May;149(2):254-62.  PMCID: PMC2860690

Quang P, Schmidt BL.  Endothelin-A Receptor Antagonism Attenuates Carcinoma-induced Pain Through Opioids in Mice.  J Pain. 2010 Jul;11(7):663-71.  PMCID: PMC2891170

Viet CT, Schmidt BL.  Methylation array analysis of preoperative and postoperative saliva DNA in oral cancer patients.  Cancer Epidemiol Biomarkers Prev. 2008 Dec;17(12):3603-11.

Schmidt BL, Tambeli CH, Gear RW, Levine JD.  Nicotine withdrawal hyperalgesia and opioid-mediated analgesia depend on nicotine receptors in nucleus accumbens.  Neuroscience, 2001;106(1):129-36.

Schmidt BL, Tambeli CH, Levine JD, Gear RW.  Mu/delta cooperativity and opposing kappa-opioid effects in nucleus accumbens-mediated antinociception in the rat.  Eur J Neurosci, 2002;15(5):861-68.

Schmidt BL, Tambeli CH, Barletta J, Luo L, Green P, Levine JD, Gear RW.  Altered nucleus accumbens circuitry mediates pain-induced antinociception in morphine-tolerant rats.  J Neurosci, 2002;22(15):6773-80.

Schmidt BL, Tambeli CH, Levine JD, Gear RW.  Adaptations in nucleus accumbens circuitry during opioid withdrawal associated with persistence of noxious stimulus-induced antinociception in the rat.  J Pain, 2003;4(3):141-147.

Connelly ST, Schmidt BL.  The evaluation of pain in patients with oral squamous cell carcinoma.  J Pain, 2004;5(9):505-10.

Snijders AM, Schmidt BL, Fridlyand J, Dekker N, Pinkel D, Jordan RC, Albertson DG.  Rare amplicons implicate frequent deregulation of cell fate specification pathways in oral squamous cell carcinoma.  Oncogene, 2005;24:4232-42.

Schmidt BL, Pickering V, Liu S, Quang P, Dolan J, Connelly ST, Jordan RC.  Peripheral endothelin A receptor antagonism attenuates carcinoma-induced pain.  Eur J Pain, 2007;11:406-14.  PMCID: PMC2771221

Kolokythas A, Connelly ST, Schmidt BL.  Validation of the University of California San Francisco Oral Cancer Pain Questionnaire.  J Pain, 2007;8:950-3.  PMCID: PMC2227312

Pickering V, Gupta RJ, Quang P, Jordan RC, Schmidt BL.  Effect of peripheral endothelin-1 concentration on carcinoma-induced pain in mice.  Eur J Pain, 2008;12:293-300. PMCID: PMC2771221

Guerrero AV, Quang P, Dekker N, Jordan RC, Schmidt BL.  Peripheral cannabinoids attenuate carcinoma induced nociception.  Neuroscience Letters, 2008;433:77-81.  PMCID: PMC2771220