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Faculty Information

Andrew I. Spielman, D.M.D., M.S., Ph.D.
Basic Science and Craniofacial Biology
Room 1033W Dental Center, 421 First Avenue
Fax: 212-995-4240



1974 D.M.D., University of Medicine and Pharmacy, Tirgu Mures, Romania
1982 Cert. in Oral Surg., Technion Institute of Technology, Haifa, Israel
1985 M.S., University of Toronto, Toronto, Canada
1988 Ph.D., Biochemistry/Oral Biology - University of Toronto, Toronto, Canada  


Research Interests / Professional Overview:

  • Dental Education
  • Mechanisms of bitter and sour taste.
  • History of Dentistry

Dental education is at a crossroads. Health care reform, interdisciplinary education, the digital revolution and the role of dentists in overall health, are all shaping how we teach and test in and outside a dental school. We are interested in innovative ways of delivering curriculum, promoting learning rather than testing, and emphasizing integration and clinical application of basic science concepts.

We are also interested in the peripheral mechanisms of taste transduction, primarily that of the bitter and sour taste. We collect human taste tissue and study taste signal transduction mechanisms monitoring generation of second messengers such as cAMP, IP3 and cGMP that accumulate in taste cells within milliseconds after gustatory stimulation. 

Finally, we are interested in the History of Medicine and Dentistry, the role others had played before us in shaping current knowledge which is essential for us to appreciate the present. 


Pub Med Articles:

Spielman AI


Representative Publications:

Relevant Publications on Taste:

Spielman, A.I., Brand, J.G. (Editors). Experimental Cell Biology of Taste and Olfaction. CRC Press, Boca Raton, FL, pp. 437, 1995.

Spielman, A.I. Chemosensory function and dysfunction. Critical Reviews in Oral Biology and Medicine, 9 (1998): 267-291.

L. Huang, Y. G. Shanker, J. Dubauskaite, J.Z. Zheng, W. Yan, S. Rosenzweig, Spielman, A.I., M. Max, R.F. Margolskee. Ggamma13, a novel G protein gamma subunit expressed in gustducin-positive taste receptor cells, mediates IP3 responses to bitter denatonium. Nature Neurosci. 2 (1999): 1055-1062.

Yan, W., Sunavala, G., Rosenzweig, S., Dasso, M., Brand, J.G. and Spielman, A.I. Bitter taste Transduced by PLC b2-dependant use in IP3 and a-gustducin-dependant fall in cyclic nucleotides. Am. J. Physiol., 280 (2001): C742 - C751.

Spielman, AI. (2009). Taste Disorders. In: Clinician's Guide to the Diagnosis and Treatment of Salivary Gland and Chemosensory Disorders, P.Fox Ed. 

Huque, T., Cowart, B. Dankulich-Nagrudny, L., Pribitkin, E.A., Bayley, D., Spielman, A.I., Feldman, R.I., Mackler, S., and Brand, J.G. (2009). Sour ageusia in Two Individuals Implicates Ion Channels of the ASIC and PKD Families in Sour Taste Perception of the Anterior Tongue. PLos  ONE, 4;10, e7347:1-11.

Ozdener, M.H. , Brand, J.G., Spielman, A.I.,  Lischka, F.,Teeter, J.H., Breslin, P., Rawson, N.E. (2011). Characterization of Human Fungiform Taste Bud Cells in Culture. Chemical Senses, 36.7, 601-12. (

Spielman, A.I., Brand JG, Buischi,  and Brett, W. (2011). Resemblance of Tongue Anatomy in Twins. Twin Research and Human Genetics, 14 (3):277-82. (

Ozdener, M.H., Spielman, A.I., Rawson, N.E. (2012). Isolation and Culture of Human Fungiform Taste Papillae Cells. Journal of Visualized Experiments (JoVE), (63), e3730, DOI: 10.3791/3730. (


Relevant Publications on Education

Spielman, AI, Fulmer, T., Eisenberg, E. and Alfano, MC (2005). Dentistry, Nursing and Medicine: A Comparison of Core Competencies. J. Dent. Edu., 69:1257-1271.

Spielman, AI and Wolff M. (2008)  Evidence-based Dentistry: Why It Should Become Standard Practice? J. Dent. Edu.  72:3.


Relevant Publications on History of Dentistry:

Spielman, AI (2007). The Birth of the Most Important 18th Century Dental text: Pierre Fauchard's Le Chirurgien Dentist. J. Dent. Res., 10: 922-926.

Spielman, AI (2009). The Boy with the Golden Tooth. - 1595 Case Report about the Use of Gold Foil in Dentistry. J. Dent. Res. 88:8-11.

Seiler, R.,  Spielman, A.I., Zink A., and Rühli, F. (2013). The Oral Pathologies of the Neolithic Iceman - ca 3300 BC - European J. Oral Sciences (Accepted)