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Faculty Information

Juhee Jeong, PhD
Assistant Professor
Basic Science and Craniofacial Biology
Room 902D Schwartz Hall, 345 East 24Th Street
E-mail:

 

Education:

1999    B.S. Biological Sciences. Korea Advanced Institute of Science and Technology (KAIST)

2004    Ph.D. Biochemistry. Harvard University

2010    Postdoc. Craniofacial Development. University of California, San Francisco (UCSF)

 

Research Interests / Professional Overview:

As a developmental biology laboratory, we strive to understand the mechanisms by which cells acquire positional identity within embryonic tissue and thereby develop into a specific part of an organ. In particular, we are investigating the molecular genetic mechanisms behind craniofacial morphogenesis with emphasis on transcriptional regulation. Our laboratory utilizes multidisciplinary approaches including mouse genetics, genomics, biochemistry and molecular biology.

 

Representative Publications:

Almaidhan, A.*, Cesario, J.*, Landin Malt, A., Zhao, Y., Sharma, N., Choi, V. and Jeong, J. (2013). Neural crest-specific deletion of Ldb1 leads to cleft secondary palate with impaired palatal shelf elevation. BMC Developmental Biology 14:3. *: Equal contributors.

Jeong, J.*, Cesario, J., Zhao, Y., Burns, L., Westphal, H. and Rubenstein, J.L.R.* (2012). Cleft palate defect of Dlx1/2-/- mouse mutant is caused by lack of vertical outgrowth in the posterior palate. Developmental Dynamics 241(11):1757-1769. *: Corresponding authors.

Chong, H.J., Young, N.M., Hu, D., Jeong, J., McMahon, A.P., Hallgrimsson, B. and Marcucio, R.S. (2012). Signaling by SHH rescues facial defects following blockade in the brain. Developmental Dynamics 241(2):247-256.

Flandin-Blety, P., Zhao, Y., Vogt, D., Jeong, J., Long, J.E., Westphal, H. and Rubenstein, J.L.R. (2011). Lhx6 and Lhx8 coordinately induce neuronal expression of Shh that controls the generation of interneuron progenitors. Neuron 70(5):939-950.

Jeong, J.*, Li, X., McEvilly, R.J., Rosenfeld, M.G., Lufkin, T. and Rubenstein, J.L.R.* (2008). Dlx genes pattern mammalian jaw primordium by regulating both lower jaw-specific and upper jaw-specific genetic programs. Development 135(17):2905-2916. *: Corresponding authors.

Chamberlain, C.E., Jeong, J., Guo, C., Allen, B.L. and McMahon, A.P. (2008). Notochord-derived Shh forms a gradient at the basal body of ventral neural progenitors coincident with Shh-dependent specification of distinct cell identities. Development 135(6):1097-1106.

Jeong, J. and McMahon, A.P. (2005). Growth and pattern of the mammalian neural tube are governed by partially overlapping feedback activities of the Hedgehog antagonists Patched1 and Hhip1. Development 132(1):143-154.

Tian, H.*, Jeong, J.*, Harfe, B.D., Tabin, C.J. and McMahon, A.P. (2005). Mouse Disp1 is required in Sonic hedgehog-expressing cells for paracrine activity of the cholesterol-modified ligand. Development 132(1):133-142. *: Equal contribution.

Jeong, J., Mao, J., Tenzen, T., Kottmann, A.H. and McMahon, A.P. (2004). Hedgehog signaling in the neural crest cells regulates the patterning and growth of facial primordia. Genes & Development 18(8):937-951.

Charron, F., Stein, E., Jeong, J., McMahon, A.P. and Tessier-Lavigne, M. (2003). The morphogen Sonic hedgehog is an axonal chemoattractant that collaborates with Netrin-1 in midline axon guidance. Cell 113(1):11-23.

Jeong, J. and McMahon, A.P. (2002). Cholesterol modification of Hedgehog family proteins. Review. Journal of Clinical Investigation 110(5):591-596.

Jeong, J. and McMahon, A.P. (2001). Vesicles and the spinal cord. News and Views. Nature 412(6843):136-137.