Researchers found computerized intervention may aid antiretroviral therapy

Red ribbon for HIV/AIDS

Antiretroviral therapy (ART), the primary type of treatment for the human immunodeficiency virus (HIV), can reduce sexual transmission, prevent illness, and increase longevity and quality of life for patients. However, according to current data, only an estimated 77-percent of U.S patients on ART therapy have suppressed viral loads. This suggests patients’ adherence to the current ART treatment regiments is in need of improvement to reduce the viral load and also to lower sexual transmission risk behaviors.

Now, new research from faculty affiliated with New York University’s Center for Drug Use and HIV Research (CDUHR) at the NYU College of Nursing (NYUCN), published in the Journal of Acquired Immune Deficiency Syndromes, shows that computerized counseling is a promising intervention for increased ART adherence and safer sex, especially for individuals with problems in these areas. This is the first intervention to report improved ART adherence, viral suppression, and reduced secondary sexual transmission risk behavior.

“The computer-delivered intervention model, Computer Assessment & Rx Education (CARE+), is a .Net-based custom software application with intervention content based on theoretical frameworks, which acts as additional support for traditional ART treatment,” said Ann Kurth, PhD, CNM, FAAN, Professor; Executive Director, NYUCN Global; and Associate Dean for Research, NYU Global Institute of Public Health. “The tool incorporates evidence-based elements shown to improve ART adherence or reduce sexual risk, as well as a personalized printout summarizing feedback, health plan and referral phone numbers.”

The objective of the study, “Computerized Counseling Reduces HIV-1 Viral Load and Sexual Transmission Risk: Findings from a Randomized Controlled Trial,” was to evaluate the potential effectiveness of a computerized intervention made specifically to support patients towards positive behavioral change. The study included 240 participants who were randomly divided into two groups: one receiving CARE+ and the other group receiving only a computerized questionnaire.

By focusing on the confidence, motivations and knowledge of the participants, the study reflects a better understanding of how behaviors affect ART adherence and HIV transmission risk. The results were positive and point to a new platform for further studies in HIV self-care and prevention.

“Nearly all CARE+ intervention participants found the tool easy to use, felt the session helped as much or more than face-to-face counseling with a staff person and three out of four even preferred the computer over a human counselor in the future.”

After the nine-month period, CARE+ intervention participants overall had an average decrease in HIV viral load, had better ART adherence, and decreased the odds of transmission risks. A majority of participants also stated that their confidence in their health behavior plan success increased by 20-percent by the end of the trial.

“Computerized counseling may not have some advantages offered by a highly-skilled human counselor, but it is delivered consistently with fidelity, without need for staff time or training. Our study proves CARE+ is highly acceptable and had an efficacious impact on priority behaviors and objective measures of viral load response,” states Dr. Kurth.

Conflicts of Interest and Source of Funding: Kurth (study principal investigator) and Spielberg were co-developers of underlying software (‘CARE’) adapted for use in this intervention, with media company Resources Online, Seattle WA, from an original SBIR grant by the Centers for Disease Control and Prevention (CDC). For the remaining authors, no conflicts were declared.

This study was funded by a Health Promotion Research Initiative Mentored Scientist Award to Kurth (5 K01 PS000066), CDC. Holmes’ and Simoni’s time was supported by the University of Washington Center for AIDS Research (CFAR), an NIH funded program (P30 AI027757) that is supported by the following NIH Institutes and Centers: NIAID, NCI, NIMH, NIDA, NICHD, NHLBI, NIA. The content is solely the responsibility of the authors and does not necessarily represent the official views of the CDC or the NIH

Research team members include: A.E Kurth, F. Spielberg, C.M Cleland, B. Lambdin, D.R Bangsberg, P.A Frick, A.O Severynen, M. Clausen, R.G Norman, D. Lockhart, J.M Simoni, K.K Holmes. Affiliations: New York University College of Nursing (AEK, CMC, RGN) New York, NY; University of Washington School of Nursing (AEK, AOS, MC) Seattle, WA; Research Triangle Institute (FS) San Francisco, CA; UW Department of Global Health and Medicine (BL, DL, KKH) Seattle, WA; Pangaea Global AIDS Foundation (BL) Oakland, CA; University of California (DRB) San Francisco, CA; Harborview Medical Center (PAF) Seattle, WA; UW Psychology (JMS) Seattle, WA.

For more information about the CARE+ tool including a demo see or contact Jim Larkin at

CDUHR, funded by the National Institute on Drug Abuse, is the first center for the socio-behavioral study of substance use and HIV in the United States. The Center is dedicated to increasing the understanding of the substance use-HIV/AIDS epidemic, particularly among individuals in high-risk contexts. The Center's theme is "Discovery to Implementation & Back: Research Translation for the HIV/Substance Use Epidemic." The Center facilitates the development of timely new research efforts, enhances implementation of funded projects and disseminates information to researchers, service providers and policy makers.

About New York University College of Nursing
NYU College of Nursing is a global leader in nursing education, research, and practice. It offers a Bachelor of Science in Nursing, a Master of Arts and Post-Master’s Certificate Programs, a Doctor of Philosophy in Research Theory and Development, and a Doctor of Nursing Practice degree. For more information, visit

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