Minor Changes

Examples of changes considered to be minor and are generally well-suited to the amendment mechanism:

Note: The previously used Minor Amendment form has been replaced by the appendix method

• Substitution, addition or deletion of personnel or collaborator, excluding principal investigator.
• Addition of another strain of the same animal species
• Change in sex of animal to be used
• Small increase in animal numbers
• Need to repeat an experiment
• Addition of minor surgery
• Addition of sample collection times
• Additional noninvasive sampling
• A change in procedure that is more specific than the language required in the original protocol does not require an amendment or UAWC approval, provided the change is not expected to increase pain or distress. (e.g., changes in needle gauge, surgical instruments, vehicle for injections, and use of post-mortem tissue.)
• Replacing a procedure with another less painful, stressful or hazardous that achieves the same specific objectives
• Changing experimental design to reduce the use of animals
• Adding a comparable strain or treatment (e.g., Wistar to Sprague-Dawley; change in vector) if no change in pain, distress, or biosafety is expected.
• Addition of a funding source
• Removing a proposed experiment from a protocol.
• Updating the alternatives section of a protocol (including Policy 12).
• Changing or adding analgesia or anesthetic on veterinary recommendation.
• Adding a procedure or treatment that is considered pain category “B” if the change does not significantly increase the numbers of animals approved or the duration of the study (e.g., add a nonstressful behavioral test).