Description of the protocol review process This review process is to assure humane treatment and compliance with internationally accepted and Federal/State government mandated animal welfare standards.
When to submit an "amendment" or a "revision"
A Principal Investigator's (PI's) research plan may change and evolve while an approved study is in progress especially since protocols are often written and approved before the funding is obtained to commence work using animals.
What is a "Major" protocol Change
Examples of change in animal use procedures that could affect animal welfare and are generally considered to be major (significant), therefore warranting a revision and rewrite of the protocol for UAWC review.
What is a "Minor" protocol Change
Examples of changes considered to be minor and are generally well-suited to the amendment mechanism.
How to search for "Alternatives" to painful Procedures
The search for "alternatives" is not optional for investigators conducting research involving vertebrate animals, but is an absolute requirement of all Federal agencies involved with funding for animal research.