Courses at NYU in Prague take advantage of the legacy of the Czech Republic and the historic transformations of contemporary Central Europe. The curriculum includes courses on the extraordinary tradition of art and architecture in Central Europe, much of which is still preserved in Prague; on the cultural legacy of music and theatre that has distinguished Central Europe for centuries; on the economic and political transformations of post-Communist society; and on the history of Jews in Central Europe. Students are offered a chance to study the politics and culture of transition, exploring the role of the media, the economics of privatization, the conflict between nationalism and internationalism, and the position of minorities in present-day society. Students may also study photography and film in a city where filmmaking thrives.

Courses are taught in English at the NYU Center. Students are not required to enroll in a language course but do take a one week intensive Czech course during orientation. Students have the option to take language courses in Czech, German, Polish, or Russian.