The NYU in Prague program takes advantage of the legacy of the Czech Republic and the historic transformations of contemporary Central Europe. The curriculum includes courses on the extraordinary tradition of art and architecture in Central Europe, much of which is still preserved in Prague; on the cultural legacy of music and theatre that has distinguished Central Europe for centuries; on the economic and political transformations of post-Communist society; and on the history of Jews in Central Europe. Undergraduate courses, except language classes, are offered in English and feature art, history, business, economics, journalism, cultural studies, film, photography and music.

At NYU in Prague, students are not required to enroll in a language course, but do take a one week intensive Czech course during orientation. Students have the option to take language courses in Czech, German, Polish, or Russian.