Since the onset of the U.S. HIV epidemic in 1981, stigma and discrimination have detrimentally affected people living with HIV (PLWH) in every aspect of their lives — including employment, education, housing, insurance, health care, and relationships with family, friends and sexual partners. This has resulted in harms including the erosion of social support networks, eviction from homes, loss of work, denial of healthcare, social isolation, depression and violence. Although confidentiality laws, the Americans with Disabilities Act and state antidiscrimination laws have provided some legal protection and relief against HIV-related discrimination, and the introduction of highly active antiretroviral therapy (HAART) in 1996 dramatically increased the life expectancy of those PLWH with access to care, too many PLWH in the United States continue to be harmed by stigma and discrimination.