The National Institute of Mental Health funded the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) study, a multi-level look at different ways to treat people who are suffering from depression but whose symptoms persist after undergoing initial medical treatment. This is the largest study to examine the effectiveness of several different treatment strategies in patients whose symptoms are considered "treatment resistant." The results from this study will give patients and doctors sound information on what steps to take if a patient does not get better initial treatment. This will help doctors and patients better customize treatments to address individual needs.