Since it first “went national” in 1998, the National Youth Anti-Drug Media Campaign (the Campaign) has aired a slew of anti-drug messages in paid and donated advertising across a full range of media. But while a multiyear evaluation showed that the Campaign raised exposure to anti-drug media messages among youth, it also showed that the Campaign had no favorable effect on marijuana use — one of its key targets. But what happens when exposure to the Campaign is combined with a school-based drug prevention curriculum?