The lifetime prevalence of depression among adolescents is currently estimated to be 14.0 percent. Recent studies have shown associations between adolescent depression and the onset of cigarette smoking, alcohol use, and drug use. The 2004 National Survey on Drug Use and Health (NSDUH) includes questions for adolescents aged 12 to 17 to assess lifetime and past year major depressive episode (MDE). In the survey, MDE is defined using the diagnostic criteria set forth by the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV),4 which specifies a period of 2 weeks or longer during which there is either depressed mood or loss of interest or pleasure and at least four other symptoms that reflect a change in functioning, such as problems with sleep, eating, energy, concentration, and self-image.