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PRINCIPAL INVESTIGATOR



DR. NEVILLE R. KALLENBACH
nrk1@nyu.edu

Neville Kallenbach received his B.S. (1958) in Chemistry from Rutgers University and his Ph.D. in Chemistry from Yale University (1961) with Lars Onsager (Nobel Prize in Chemistry 1968). After NSF and NIH Postdoctoral Fellowships at UCSD with Bruno Zimm, he moved to the University of Pennsylvania in 1964, where he became Professor of Biology in 1972. In 1987 he was appointed Professor and Chairman of the Chemistry Department at NYU, a position he held until 1995.

View Curriculum Vitae

HONORS AND AWARDS


  • Selman Waksman Scholarship (1954-1958)
  • Harry I. Etelman Foundation Scholarship (1954-1958)
  • Henry Rutgers Scholar (1958)
  • American Institute of Chemists Medal for Outstanding Chemistry Major (1958)
  • Pi Mu Epsilon (1957)
  • Phi Lambda Upsilon (1957)
  • Phi Beta Kappa (1958)
  • Woodrow Wilson Fellowship (1958-59)
  • DuPont Fellowship, Yale University (1959-1960)
  • Guggenheim Fellowship, Weizmann Institute of Science and Centre de Biophysique Moleculaire, Orleans, France (1972-1973)
  • NIH Senior Research Fellow, Stanford University, Department of Biochemistry, (1981-1982)
  • Herman and Margaret Sokol Prize for Faculty Research, NYU (1994)
  • "Golden Dozen" Award for Excellence in Teaching, Washington Square College, NYU (1992), (2003)
  • The Distinguished Teaching Award , NYU (2007)

PROFESSIONAL EXPERIENCE


1964-1968 Assistant Professor of Biology, University of Pennsylvania, Philadelphia, PA
1968-1972 Associate Professor of Biology, University of Pennsylvania
1972-1987 Professor of Biology, University of Pennsylvania
1980-1984 Member & Chairman, Molecular & Cellular Biophysics Study Section, National Institutes of Health
1980-1981 Visiting Professor of Biochemistry, Stanford University School of Medicine, Palo Alto, CA (NIH Senior Fellow)
1983-1985 Director of Research, Molecular Biophysics Technologies, Inc. Philadelphia, PA.
1986 Chairman, Gordon Research Conference on Physics and Physical Chemistry of Biopolymers
1986 Program Chairman, 32nd Annual Meeting of Biophysical Society
1987-1995 Chair, Biophysics Section, New York Academy of Sciences, NY
1995- Professor of Chemistry, Department of Chemistry, New York University
1995-1999 Co-Principal Investigator, New York City Collaborative for Excellence in Teacher Preparation.
1998 Chairman, Special Study Section (Structural Genomics), NIGMS, UC Berkeley.
2001 Panel member, New Technologies Initiative, NCI-NIH.
2001 Panel member. Panel on Microbial Cell Project, Department of Energy, Georgetown, DC.
2004-2005 Member, NIH Review Panel ZRG1 BST-F, Assays and Methods Development
2007- Director of Science Programs, Faculty Resource Network, New York University

MEDIA INTERVIEW

SELECTED PUBLICATIONS

  1. Spin relaxation enhancement confirms dominance of extended conformations in short alanine peptides. Chen, Kang; Liu, Zhigang; Zhou, Chunhui; Bracken, W. Clay; Kallenbach, Neville R. Angewandte Chemie, International Edition (2007), 46(47), 9036-9039.
  2. A seven-helix coiled coil. Liu, Jie; Zheng, Qi; Deng, Yiqun; Cheng, Chao-Sheng; Kallenbach, Neville R.; Lu, Min. Proceedings of the National Academy of Sciences of the United States of America (2006), 103(42), 15457-15462.
  3. Conformation of the backbone in unfolded proteins. Shi Z, Chen K, Liu Z, Kallenbach NR. Chemical Review, 2006 May;106(5):1877-97
  4. Polyproline II propensities from GGXGG peptides reveal an anticorrelation with b -sheet scales. Shi, Zhengshuang; Chen, Kang; Liu, Zhigang; Ng, Angela; Bracken, W. Clay; Kallenbach, Neville R.. Proceedings of the National Academy of Sciences of the United States of America (2005), 102(50), 17964-17968.
  5. Neighbor Effect on PPII Conformation in Alanine Peptides. Chen, Kang; Liu, Zhigang; Zhou, Chunhui; Shi, Zhengshuang; Kallenbach, Neville R.. Journal of the American Chemical Society (2005), 127(29).
  6. The polyproline II conformation in short alanine peptides is noncooperative. Chen, Kang; Liu, Zhigang; Kallenbach, Neville R.. Proceedings of the National Academy of Sciences of the United States of America (2004), 101(43), 15352-15357.
  7. Atomic structure of a tryptophan-zipper pentamer. Liu, Jie; Yong, Wei; Deng, Yiqun; Kallenbach, Neville R.; Lu, Min. Proceedings of the National Academy of Sciences of the United States of America (2004), 101(46), 16156-16161.
  8. Solvent Dependence of PII Conformation in Model Alanine Peptides. Liu, Zhigang; Chen, Kang; Ng, Angela; Shi, Zhengshuang; Woody, Robert W.; Kallenbach, Neville R.. Journal of the American Chemical Society (2004), 126(46), 15141-15150.
  9. Vibrational Raman Optical Activity Characterization of Poly(L-proline) II Helix in Alanine Oligopeptides. McColl, Iain H.; Blanch, Ewan W.; Hecht, Lutz; Kallenbach, Neville R.; Barron, Laurence D. Journal of the American Chemical Society (2004), 126(16), 5076-5077.
  10. The Pentapeptide GGAGG Has PII Conformation. Ding, Liang; Chen, Kang; Santini, Paul A.; Shi, Zhengshuang; Kallenbach, Neville R.. Journal of the American Chemical Society (2003), 125(27), 8092-8093.
  11. D/H Amide Isotope Effect in Model a -Helical Peptides. Shi, Zhengshuang; Olson, C. Anders; Kallenbach, Neville R.; Sosnick, Tobin R. Journal of the American Chemical Society (2002), 124(47), 13994-13995.
  12. Polyproline II structure in a sequence of seven alanine residues. Shi, Zhengshuang; Olson, C. Anders; Rose, George D.; Baldwin, Robert L.; Kallenbach, Neville R.. Proceedings of the National Academy of Sciences of the United States of America (2002), 99(14), 9190-9195.
  13. Cation-p interaction in model a -helical peptides. Shi, Zhengshuang; Olson, C. Anders; Kallenbach, Neville R.. Journal of the American Chemical Society (2002), 124(13), 3284-3291.
  14. Polar Interactions with Aromatic Side Chains in a -Helical Peptides: CH××× O H-Bonding and Cation-p Interactions. Olson, C. Anders; Shi, Zhengshuang; Kallenbach, Neville R.. Journal of the American Chemical Society (2001), 123(26), 6451-6452.
  15. Breaking open a protein barrel. Kallenbach, Neville. Proceedings of the National Academy of Sciences of the United States of America (2001), 98(6), 2958-2960.
  16. Alanine Is an Intrinsic a -Helix Stabilizing Amino Acid. Spek, Erik J.; Olson, C. Anders; Shi, Zhengshuang; Kallenbach, Neville R.. Journal of the American Chemical Society (1999), 121(23), 5571-5572.
  17. a -Helix Nucleation Constant in Copolypeptides of Alanine and Ornithine or Lysine. Yang, Jianxin; Zhao, Kang; Gong, Youxiang; Vologodskii, Alexander; Kallenbach, Neville R.. Journal of the American Chemical Society (1998), 120(41), 10646-10652.
  18. Stabilizing Effect of a Multiple Salt Bridge in a Prenucleated Peptide. Mayne, Leland; Englander, S. Walter; Qiu, Rong; Yang, Jianxin; Gong, Youxiang; Spek, Erik J.; Kallenbach, Neville R.. Journal of the American Chemical Society (1998), 120(41), 10643-10645.
  19. The role of alanine sequences in forming b -sheets of spider dragline silk. Spek, Erik J.; Wu, Huai-Chuan; Kallenbach, Neville R.. Journal of the American Chemical Society (1997), 119(21), 5053-5054.
  20. Origami anyone? Kallenbach, Neville. Nature (London) (1996), 383(6595), 37.
  21. Breathing life into the folding pathway of cytochrome c. Kallenbach, Neville R.. Nature Structural Biology (1995), 2(10), 813-16.
  22. A method for probing the topography and interactions of proteins: Footprinting of myoglobin. Zhong, Min; Lin, Laura; Kallenbach, Neville R.. Proceedings of the National Academy of Sciences of the United States of America (1995), 92(6), 2111-15.
  23. Molten globular characteristics of the native state of apomyoglobin. Lin, Laura; Pinker, Rachel J.; Forde, Kirk; Rose, George D.; Kallenbach, Neville R.. Nature Structural Biology (1994), 1(7), 447-52.
  24. DNA branched junctions. Seeman, Nadrian C.; Kallenbach, Neville R.. Annual Review of Biophysics and Biomolecular Structure (1994), 23 53-86.
  25. Quantitative evaluation of stabilizing interactions in a prenucleated a -helix by hydrogen exchange. Zhou, Hongxing X.; Hull, Leslie A.; Kallenbach, Neville R.; Mayne, Leland; Bai, Yawen; Englander, S. Walter. Journal of the American Chemical Society (1994), 116(14), 6482-3.
  26. Structure of a C-Terminal a -Helix Cap in a Synthetic Peptide. Zhou, Hongxing X.; Lyu, Pingchiang C.; Wemmer, David E.; Kallenbach, Neville R.. Journal of the American Chemical Society (1994), 116(3), 1139-40.
  27. Position-dependent stabilizing effects in a -helices: N-terminal capping in synthetic model peptides. Lyu, Pingchiang C.; Zhou, Hongxing X.; Jelveh, Nazanin; Wemmer, David E.; Kellenbach, Neville R.. Journal of the American Chemical Society (1992), 114(16), 6560-2.
  28. a -Helix stabilization by natural and unnatural amino acids with alkyl side chains. Lyu, Pingchiang C.; Sherman, John C.; Chen, Amy; Kallenbach, Neville R.. Proceedings of the National Academy of Sciences of the United States of America (1991), 88(12), 5317-20.
  29. Local effect of glycine substitution in a model helical peptide. Lyu, Pingchiang C.; Wang, Ping Chuan; Liff, Mark I.; Kallenbach, Neville R.. Journal of the American Chemical Society (1991), 113(9), 3568-72.
  30. Analysis of asymmetry in the distribution of helical residues in peptides by proton nuclear magnetic resonance. Liff, M. I.; Lyu, P. C.; Kallenbach, Neville R.. Journal of the American Chemical Society (1991), 113(3), 1014-19.
  31. Side chain contributions to the stability of alpha-helical structure in peptides. Lyu, P. C.; Liff, M. I.; Marky, Luis A.; Kallenbach, Neville R.. Science (Washington, DC, United States) (1990), 250(4981), 669-73.
  32. T4 endonuclease VII cleaves the crossover strands of Holliday junction analogs. Mueller, John E.; Kemper, Boerries; Cunningham, Richard P.; Kallenbach, Neville R.; Seeman, Nadrian C. Proceedings of the National Academy of Sciences of the United States of America (1988), 85(24), 9441-5.
  33. A specific quadrilateral synthesized from DNA branched junctions. Chen, Jung Huei; Kallenbach, Neville R.; Seeman, Nadrian C. Journal of the American Chemical Society (1989), 111(16), 6402-7.
  34. The role of ion pairs in a helix stability: two new designed helical peptides. Lyu, Ping Chiang; Marky, Luis A.; Kallenbach, Neville R.. Journal of the American Chemical Society (1989), 111(7), 2733-4.
  35. A Holliday recombination intermediate is twofold symmetric. Churchill, Mair E. A.; Tullius, Thomas D.; Kallenbach, Neville R.; Seeman, Nadrian C. Proceedings of the National Academy of Sciences of the United States of America (1988), 85(13), 4653-67.
  36. An immobile nucleic acid junction constructed from oligonucleotides. Kallenbach, Neville R.; Ma, Rong Ine; Seeman, Nadrian C. Nature (London, United Kingdom) (1983), 305(5937), 829-31.
  37. Site exclusion and sequence specificity in binding of 9-aminoacridine to the deoxytetranucleotide dpApGpCpT. Young, Peter R.; Kallenbach, Neville R..Proceedings of the National Academy of Sciences of the United States of America (1980), 77(11), 6453-7.
  38. Nature of the open state in long polynucleotide double helixes: Possibility of soliton excitations. Englander, S. W.; Kallenbach, N. R.; Heeger, A. J.; Krumhansl, J. A.; Litwin, S. Proceedings of the National Academy of Sciences of the United States of America (1980), 77(12), 7222-6.
  39. Phosphorus-31 magnetic resonance of DNA in nucleosome core particles of chromatin. Kallenbach, N. R.; Appleby, D. W.; Bradley, C. H. Nature (London, United Kingdom) (1978), 272(5649), 134-8.
  40. Determination of recognition sites of T4 RNA ligase on the 3'-hydroxyl and 5'-phosphate terminuses of polyribonucleotide chains. Kaufmann, Gabriel; Kallenbach, Neville R.. Nature (London, United Kingdom) (1975), 254(5499), 452-4.
  41. Theory of thermal transitions in cohered DNA from phage lambda. Kallenbach, Neville R.; Crothers, Donald M. Proceedings of the National Academy of Sciences of the United States of America (1966), 56(3), 1018-25.
  42. Selected aspects of the physical chemistry of polynucleotides and nucleic acids. Zimm, Bruno H.; Kallenbach, Neville R.. Ann. Rev. Phys. Chem. (1962), 13, 171-94.

BOOK CHAPTERS

  1. Conformational analysis of unfolded states of peptides by UV-CD and NMR. Chen, K.; Liu, Z.; Bracken, C.W.; Kallenbach, N.R. Unfolded proteins: from denatured states to intrinsically disordered., Nova Science Publishers, Inc., New York, Jan, 2008
  2. CD spectroscopy and the helix-coil transition in peptides and polypeptides. Kallenbach, Neville R.; Lyu, Pingchiang; Zhou, Hongxing. Department Chemistry, New York University, New York, NY, USA. Editor(s): Fasman, Gerald D. Circular Dichroism and the Conformational Analysis of Biomolecules (1996), 201-259. Publisher: Plenum, New York, N. Y
  3. Chemistry and Physics of DNA-Ligand Interactions. Kallenbach, Neville R.; Editor. USA. (1990), 212 pp. Publisher: (Adenine Press, Schenectady, N.Y.)

PATENTS

  1. Kallenbach, N.; Chang, Y-T.; Liu, Z.; Min, J. Triazine compounds, pharmaceutical compositions and methods of using the same. PCT Int. Appl. (2007), filed
  2. Liu, Z.; Kallenbach, N.; Young, A.W.; Zhou, C.; Dendrimer peptides, pharmaceutical compositions and methods of using the same. PCT Int. Appl. (2007), filed
  3. Malamud, Daniel; Abrams, William; Arora, Paramjit; Liu, Zhigang; Kallenbach, Neville. Pharmaceutical compositions comprising antimicrobial or antiviral polypeptides conjugated with biocompatible polymers for treating microbial or viral infection. PCT Int. Appl. (2007), 169pp. CODEN: PIXXD2 WO 2007025178 A2 20070301 CAN 146:294175 AN 2007:226841
  4. Seeman, Nadrian C.; Chen, Junghuei; Kallenbach, Neville R.. Multiply-connected, three-dimensional nucleic acid structures. PCT Int. Appl. (1992), 42 pp. CODEN: PIXXD2 WO 9212164 A1 19920723 CAN 117:146749 AN 1992:546749
  5. Kim, Peter S.; Kallenbach, Neville R.. Antibodies to transition state analogs as catalysts. Eur. Pat. Appl. (1989), 24 pp. CODEN: EPXXDW EP 305870 A2 19890308 CAN 111:211068 AN 1989:611068
  6. Kallenbach, Neville R.; Kim, Peter S. Production of antibody catalysts. Eur. Pat. Appl. (1988), 33 pp. CODEN: EPXXDW EP 251093 A2 19880107 CAN 110:152652 AN 1989:152652
  7. Cornelius, Paul A.; Hochstrasser, Robin M.; Kallenbach, Neville R.; Rubin, Harvey; Todaro, George J. Sterilizing biological media by selective photolysis. Ger. Offen. (1985), 49 pp. CODEN: GWXXBX DE 3505728 A1 19850905 CAN 105:130648 AN 1986:530648