Recent Publications (1999 - 2002):    

STRUCTURE AND FUNCTION OF CARCINOGEN AND OTHER DNA ADDUCTS 

Nucleic Acids Res., Response of human REV1 to different DNA damage: Preferential dCMP insertion opposite the lesion. Zhang, Y., Wu, X., Rechkoblit, O., Geacintov, N.E., Taylor, J.-S., Wang^, Z.,  In press (2002).

Fluorescence Characteristics of Site-Specific and Stereochemically Distinct Benzo[a]pyrene Diol Epoxide-DNA Adducts as Probes of Adduct Conformation. Huang, W.,  Amin, S.,  Geacintov, N.E. (2002), Chem. Res.  Toxicol.  15(2),  118-126.

Conformational changes of a benzo[a]pyrene diol epoxide-N²-dG adduct induced by a 5’-flanking 5-methyl substituted cytosine in a ^5MeCG double-stranded oligonucleotide sequence context. Huang, X., Colgate, K.C., Kolbanoviskiy, A.,  Amin, S., and Geacintov, N.E., (2002), Chem. Res. Toxicol. 15, 438-444.

Synthesis and Characterization of Site-Specific and Stereoisomeric Fjord Dibenzo[a,l]pyrene Diol Epoxide-N6-Adenine Adducts: Unusual Thermal Stabilization of Modified DNA Duplexes. Ruan, Q.,  Kolbanovskiy, A., Zhuang, P., Chen, J., Krzeminski, J., Amin, S.,  Geacintov, N.E. (2002), Chem. Res.  Toxicol.  15(2),  249-261.

Conformational changes of a benzo[a]pyrene diol epoxide-N²-dG adduct induced by a 5’-flanking 5-methyl substituted cytosine in a ^5MeCG double-stranded oligonucleotide sequence context. Huang, X., Colgate, K.C., Kolbanoviskiy, A.,  Amin, S., and Geacintov, N.E., (2002), Chem. Res. Toxicol. 15, 438-444.

Molecular topology of polycyclic aromatic carcinogens determines DNA adduct conformation: A link to tumorogenic  activity. Lin C.H., Huang X.W., Kolbanovskii A., Hingerty B.E., Amin S., Broyde S., Geacintov N.E., Patel D.J.  J. Mol. Biol. (2001), 306, 1059-1080.

Hierarchy of DNA damage recognition in Escherichia coli nucleotide excision repair. Zou Y., Luo C., Geacintov N.E. Biochemistry  (2001), 40,  2923-2931.

Bacteriophage T7 RNA polymerase transcription elongation is inhibited by site-specific, stereospecific benzo[c]phenanthrene diol epoxide DNA lesions. Roth, Richard B.; Amin, Shantu; Geacintov, Nicholas E.; Scicchitano, David A.  Biochemistry  (2001), 40, 5200-5207.

Influence of bulky polynuclear carcinogen lesions in a TATA promoter sequence on TATA binding protein-DNA complex formation. Rechkoblit, O., Krzeminsky, J.,  Amin, S.,  Jernstroem, B.,  Louneva, N.,  Geacintov, N.E.  Biochemistry (2001), 40,  5622-5632.

Base Sequence Dependence of in Vitro Translesional DNA Replication past a Bulky Lesion Catalyzed by the Exo- Klenow Fragment of Pol I. Zhuang, P., Kolbanovskiy, A.,  Amin, S.,  Geacintov, N.E.  Biochemistry (2001), 40, 6660-6669.

Stereochemical, structural and thermodynamic origins of stability differences between stereoisomeric benzo[a]pyrene diol epoxide deoxyadenosine adducts in a DNA mutational hot spot sequence. Yan, S., Shapiro, Geacintov, N.E., and Broyde, S., J. Am. Chem. Soc. (2001), 123, 754-766.

Base Sequence Effects in Bending Induced by Bulky Carcinogen-DNA Adducts: Experimental and Computational Analysis. Ruan, Q.,  Zhuang, P.,  Li, S.,  Perlow, R.,  Srinivasan, A. R.; Lu, X.-J., Broyde, S.,  Olson, W.K., and  Geacintov, N.E.  Biochemistry  (2001), 40(35),  10458-10472.

Announcements-Invitation to the meeting of the division of chemical toxicology to be held at the 22nd National Meeting of the American Chemical Society, August 26-30, 2001, Chicago. Geacintov, N.,  Division of Chemical Toxicology, Chem. Res. Toxicol. (2001), 14(5),  461-462.

Stereochemical Origin of Opposite Orientations in DNA Adducts Derived from Enantiomeric anti-Benzo[a]pyrene Diol Epoxides with Different Tumorigenic Potentials.  Xie, Xiao-Ming; Geacintov, Nicholas E.; Broyde, Suse    Biochemistry  (1999),  38(10),  2956-2968.

Solution Conformation of the (+)- trans-anti -benzo[g]chrysene-dA Adduct Opposite dT in a DNA Duplex, Suri, Asif K.; Mao, Bing; Amin, Shantu; Geacintov, Nicholas E.; Patel, Dinshaw J.,  J. Mol. Biol.  (1999),  292(2),  289-307.

Primer Length - Dependence of Formation of Monomeric and Dimeric DNA Polymerase I (Klenow Fragment) - Template/Primer Complexes Containing Site-Specific Bulky Lesions.  Rechkoblit, Olga, Amin, Shantu, and Geacintov, Nicholas E., Biochemistry 38, 11834-11840 (1999).

Origins of Conformational Differences between Cis and Trans DNA Adducts Derived from Enantiomeric anti-Benzo[a]Pyrene Diol Epoxides. Xie, Xiao-Ming; Geacintov, Nicholas E.; Broyde, Suse. Chem. Res. Toxicol.  (1999),  12(7),  597-609.

The major, N2-dG adduct of (+)-anti-B[a]PDE induces G®A mutations in a 5'-AGA-3' sequence context. Shukla, Rajiv; Geacintov, Nicholas E.; Loechler, Edward L.    Department of Biology,  Boston University,  Boston,  MA,  USA. Carcinogenesis  (1999),  20(2),  261-268.

Solution Structure of the (+)-cis-anti-Benzo[a]pyrene-dA ([BP]dA) Adduct Opposite dT in a DNA Duplex. Mao, Bing; Gu, Zhentian; Gorin, Andrey; Chen, Junxin; Hingerty, Brian E.; Amin, Shantu; Broyde, Suse; Geacintov, Nicholas E.; Patel, Dinshaw J., Biochemistry  (1999),  38(33),  10831-10842.

Mismatch repair processing of carcinogen-DNA adducts triggers apoptosis. Wu, Jianxin; Gu, Liya; Wang, Huixian; Geacintov, Nicholas E.; Li, Guo-Min., Mol. Cell. Biol.  (1999),  19(12),  8292-8301.

Total synthesis, mass spectrometric sequencing, and stabilities of oligonucleotide duplexes with single trans-anti-BPDE-N6-dA lesions in the N-ras codon 61 and other sequence contexts.     Krzeminski, Jacek; Ni, Jinsong; Zhuang, Ping; Luneva, Natalia; Amin, Shantu; Geacintov, Nicholas E.. Polycyclic Aromat. Compd.  (1999),  17(1-4),  1-10.

Principles Governing Conformations in Stereoisomeric Adducts of Bay Region Benzo[a]pyrene Diol Epoxides to Adenine in DNA: Steric and Hydrophobic Effects Are Dominant.     Tan, Jian; Geacintov, Nicholas E.; Broyde, Suse.  J. Am. Chem. Soc.  (2000),  122(13),  3021-3032.

Unrepaired fjord region polycyclic aromatic hydrocarbon-DNA adducts in ras codon 61 mutational hot spots.     Buterin, Tonko; Hess, Martin T.; Luneva, Natalia; Geacintov, Nicholas E.; Amin, Shantu; Kroth, Heiko; Seidel, Albrecht; Naegeli, Hanspeter.  Cancer Res.  (2000),  60(7),  1849-1856.

Differential Incision of Bulky Carcinogen-DNA Adducts by the UvrABC Nuclease: Comparison of Incision Rates and the Interactions of Uvr Subunits with Lesions of Different Structures.     Hoare, Sarasija; Zou, Yue; Purohit, Vandana; Krishnasamy, Ramji; Skorvaga, Milan; Houten, Bennett Van; Geacintov, Nicholas E.; Basu, Ashis K.     Biochemistry  (2000),  39(40),  12252-12261.

Accommodation of S-cis-Tamoxifen-N2-Guanine Adduct within a Bent and Widened DNA Minor Groove.  Shimotakahara, Sakurako; Gorin, Andrey; Kolbanovskiy, Alexander; Kettani, Abdelali; Hingerty, Brian E.; Amin, Shantu; Broyde, Suse; Geacintov, Nicholas; Patel, Dinshaw J.   J. Mol. Biol.  (2000),  302(2),  377-393.

REVIEW ARTICLE

NMR solution structures of stereoisomeric polycyclic aromatic carcinogen-DNA adducts: principles, patterns, and diversity. Geacintov, N.E.,Cosman, M., Hingerty, B.E., Amin, S., Broyde, S., and Patel, D.J. (1997)  Chem. Res. Toxicol. 10, 111-146.

ELECTRON TRANSFER REACTIONS IN DNA AND NUCLEIC ACIDS - 

PHOTOPHYSICAL AND BIOCHEMICAL INVESTIGATIONS

The carbonate radical is a site-selective oxidizing agent of guanine in double-stranded oligonucleotides. The carbonate radical is a site-selective oxidizing agent of guanine in double-stranded oligonucleotides. Shafirovich V, Dourandin A, Huang WD,  Geacintov, N.E., (2001), J. Biol. Chem. 276, 24621-24626.

Proton-Coupled Electron-Transfer Reactions at a Distance in DNA Duplexes: Kinetic Deuterium Isotope Effect, Proton-Coupled Electron-Transfer Reactions at a Distance in DNA Duplexes: Kinetic Deuterium Isotope Effect, Shafirovich, V.,  Dourandin, A., Geacintov, N.E., (2001), J. Phys. Chem. B, 105(35),  8431-8435. 

Nitrogen dioxide as an oxidizing agent of 8-oxo-7,8-dihydro-2 '-deoxyguanosine but not of 2 '-deoxyguanosine. Nitrogen dioxide as an oxidizing agent of 8-oxo-7,8-dihydro-2 '-deoxyguanosine but not of 2 '-deoxyguanosine. Shafirovich V., Cadet J., Gasparutto D., Dourandin A., Geacintov N.E., (2001), Chem. Res. Toxicol. 14,  233-241.

Direct spectroscopic observation of 8-oxo-7,8-dihydro-2 '-deoxyguanosine radicals in double-stranded DNA generated by one-electron oxidation at a distance by 2-aminopurine radicals. Direct spectroscopic observation of 8-oxo-7,8-dihydro-2 '-deoxyguanosine radicals in double-stranded DNA generated by one-electron oxidation at a distance by 2-aminopurine radicals. Shafirovich V., Cadet J., Gasparutto D., Dourandin A., Huang W.D., Geacintov N.E., (2001), J. Phys. Chem. B 105,  586-592.

Multiphoton near-infrared femtosecond laser pulse-induced DNA damage with and without the photosensitizer proflavine. Shafirovich, Vladimir; Dourandin, Alexander; Luneva, Natalia P.; Singh, Carolyn; Kirigin, Francis; Geacintov, Nicholas E., Photochem. Photobiol.  (1999),  69(3),  265-274.  

Proton-coupled electron transfer in the oxidation of guanines by an aromatic pyrenyl radical cation in aqueous solutions.     Kuzmin, Vladimir A.; Dourandin, Alexander; Shafirovich, Vladimir; Geacintov, Nicholas E..  Phys. Chem. Chem. Phys.  (2000),  2(7),  1531-1535. 

The Kinetic Deuterium Isotope Effect as a   Probe of a Proton Coupled Electron Transfer Mechanism in the Oxidation of Guanine by 2-Aminopurine  Radicals, Shafirovich, V., Dourandin, A., Luneva, N. P., Geacintov, N. E., The Journal of Physical Chemistry B104, 137-139 (2000).  

Acid-base equilibria in aqueous solutions of 2-aminopurine radical cations generated by two-photon photoionization.  Shafirovich, Vladimir; Dourandin, Alexander; Luneva, Natalia P.; Geacintov, Nicholas E.  J. Chem. Soc.  Perkin Trans. 2  (2000),   (2),  271-275. 

Electron transfer at a distance induced by site-selective photoionization of 2-aminopurine in oligonucleotides and investigated by transient absorption techniques.     Shafirovich, Vladimir; Dourandin, Alexander; Huang, Weidong; Luneva, Natalia P.; Geacintov, Q-Nicholas E..    Chemistry Department and Radiation and Solid State Laboratory,  New York University,  NY,  USA.    Phys. Chem. Chem. Phys.  (2000),  2(19),  4399-4408. 

Oxidation of Guanine at a   Distance in Oligonucleotides Induced by Two-Photon Photoionization of 2-Aminopurine, Shafirovich, V., Dourandin, A., Huang, W., Luneva, N. P., Geacintov, N. E. The Journal of Physical Chemistry B (1999),  103(49); 10924-10933.  

PHOTOPHYSICS OF ORGANIC SYSTEMS

New broad spectrum autocorrelator for ultrashort light pulses based on multiphoton photoemission.     Dourandin, Alexander; Brenner, Henry C.; Pope, Martin. Rev. Sci. Instrum.  (2000),  71(4),  1589-1594.