Research Professor, Professor 1995 (Chemical Kinetics and Catalysis), Academy of Sciences, Russia, Doctor  of Chemical Science 1987, Academy of Sciences, USSR, Ph. D. 1979, Academy of Sciences, USSR, M.S. 1973, Moscow State University, Russia.

E-mail: vs5@nyu.edu

Lab. phone: (212) 998 - 8456

Projects:

1996-Present:

Nano- and Picosecond Laser Flash Photolysis of Site-Specifically and Covalently Modified Benzo[a]pyrene Diol Epoxide-Oligonucleotide Adducts.

Chemistry Department, New York University, New York  

1994-1996:

Nanosecond Laser Flash Photolysis in Studies of Magnetic Field Effects on Recombination Kinetics of Chain-Linked Triplet Radical Pairs.

Russian Academy of Sciences, Institute of Chemical Physics, Chernogolovka  

1992-1994:

Nanosecond Laser Flash Photolysis and Time-Correlated Single-Photon Counting                      Studies of Photoinduced Electron Transfer in Benzo[a]pyrene Derivative-Nucleic Acid                           Complexes and Covalent Adducts.

Chemistry Department, New York University, New York

1974-1992:

Nanosecond Laser Flash Photolysis in Studies of Magnetic Field Effects and Photoinduced Electron Transfer Reactions, Catalytic Redox-Processes in Organized Molecular Assemblies Initiated by Photoinduced Electron Transfer, Light-Induced Electron Transfer Across Bilayer Membranes. Molecular Design of Photocatalytic Systems Encapsulated in Bilayer vesicles. Synthesis of the Catalysts for Oxygen and Hydrogen Evolution from Water.

Russian Academy of Sciences, Institute of Chemical Physics, Chernogolovka

EXPERTISE:

Chemical Kinetics, Redox-Catalysis, Photoinduced Electron Transfer, Magnetic Field Effects in Chemical Reactions Nanosecond Laser Flash Photolysis.

SPECIAL LECTURES AND POSITIONS:

1982: Research Scientist, Central Research Institute for Chemistry, Budapest, Hungary

1990: Guest Professor, Laboratoire de Physico-Chimie des Rayonnements, Université de Paris-                       Sud, Paris, France.

1991: Research Scientist, Institut für Molekülphysik, Freie Universität Berlin, Berlin, Germany.

1991: Lecturer, Max-Volmer-Institute für Biophysikalische und Physikalische Chemie, Berlin, 1994:

RECENT PUBLICATIONS:

Photochemically Catalyzed Generation of Site-Specific 8-Nitroguanine Adducts in DNA by the Reaction of Long-Lived Neutral Guanine Radicals with Nitrogen Dioxide.     Shafirovich, Vladimir; Mock, Steven; Kolbanovskiy, Alexander; Geacintov, Nicholas E.    Chemistry Department and Radiation and Solid State Laboratory,  New York University,  New York,  NY,  USA.    Chemical Research in Toxicology     ACS ASAP. 

Site-specific nitro-guanine adducts derived from a combination of nitrogen dioxide with long-lived neutral guanine radicals in DNA.     Shafirovich, Vladimir; Mock, Steven; Kolbanovskiy, Alexander; Geacintov, Nicholas E.    Chemistry Department,  New York University,  New York,  NY,  USA.    Abstracts of Papers, 222nd ACS National Meeting, Chicago, IL, United States, August 26-30, 2001  (2001),     TOXI-025.  Publisher: American Chemical Society,  Washington, D. C.

Influence of the linking chain length on the recombination kinetics of covalently bonded triplet radical pairs and magnetic field effects.     Shafirovich, V. Ya.; Levin, P. P.    N. M. Emanuel Institute of Biochemical Physics,  Russian Academy of Sciences,  Moscow,  Russia.    Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, Seriya Khimicheskaya)  (2001),  50(4),  599-606.

Proton-Coupled Electron-Transfer Reactions at a Distance in DNA Duplexes: Kinetic Deuterium Isotope Effect.     Shafirovich, Vladimir; Dourandin, Alexander; Geacintov, Nicholas E.    Chemistry Department and Radiation and Solid State Laboratory,  New York University,  New York,  NY,  USA.    Journal of Physical Chemistry B  (2001),  105(35),  8431-8435.

The carbonate radical is a site-selective oxidizing agent of guanine in double-stranded oligonucleotides.  Shafirovich, Vladimir; Dourandin, Alexander; Huang, Weidong; Geacintov, Nicholas E.    Chemistry Department and Radiation and Solid State Laboratory,  New York University,  New York,  NY,  USA.    Journal of Biological Chemistry  (2001),  276(27),  24621-24626. 

Nitrogen Dioxide as an Oxidizing Agent of 8-Oxo-7,8-dihydro-2'-deoxyguanosine but Not of 2'-Deoxyguanosine.     Shafirovich, Vladimir; Cadet, Jean; Gasparutto, Didier; Dourandin, Alexander; Geacintov, Nicholas E.    Chemistry Department and Radiation and Solid State Laboratory,  New York University,  New York,  NY,  USA.    Chemical Research in Toxicology  (2001),  14(2),  233-241. 

Direct Spectroscopic Observation of 8-Oxo-7,8-dihydro-2'-deoxyguanosine Radicals in Double-Stranded DNA Generated by One-Electron Oxidation at a Distance by 2-Aminopurine Radicals.     Shafirovich, Vladimir; Cadet, Jean; Gasparutto, Didier; Dourandin, Alexander; Huang, Weidong; Geacintov, Nicholas E.    Chemistry Department and Radiation and Solid State Laboratory,  New York University,  New York,  NY,  USA.    Journal of Physical Chemistry B  (2001),  105(2),  586-592. 

Electron transfer at a distance induced by site-selective photoionization of 2-aminopurine in oligonucleotides and investigated by transient absorption techniques.     Shafirovich, Vladimir; Dourandin, Alexander; Huang, Weidong; Luneva, Natalia P.; Geacintov, Nicholas E.    Chemistry Department and Radiation and Solid State Laboratory,  New York University,  New York,  NY,  USA.    Physical Chemistry Chemical Physics  (2000),  2(19),  4399-4408. 

Proton-coupled electron transfer in the oxidation of guanines by an aromatic pyrenyl radical cation in aqueous solutions.     Kuzmin, Vladimir A.; Dourandin, Alexander; Shafirovich, Vladimir; Geacintov, Nicholas E.    Chem. Dep. and Radiation Solid State Lab.,  New York Univ.,  New York,  NY,  USA.    Phys. Chem. Chem. Phys.  (2000),  2(7),  1531-1535.

Acid-base equilibria in aqueous solutions of 2-aminopurine radical cations generated by two-photon photoionization.     Shafirovich, Vladimir; Dourandin, Alexander; Luneva, Natalia P.; Geacintov, Nicholas E.    Chemistry Department and Radiation and Solid State Laboratory,  New York University,  New York,  NY,  USA.    Perkin 2  (2000),   (2),  271-275. 

The Kinetic Deuterium Isotope Effect as a Probe of a Proton Coupled Electron Transfer Mechanism in the Oxidation of Guanine by 2-Aminopurine Radicals.     Shafirovich, Vladimir; Dourandin, Alexander; Luneva, Natalia P.; Geacintov, Nicholas E.    Chemistry Department and Radiation and Solid State Laboratory,  New York University,  New York,  NY,  USA.    J. Phys. Chem. B  (2000),  104(1),  137-139.  

Oxidation of Guanine at a Distance in Oligonucleotides Induced by Two-Photon Photoionization of 2-Aminopurine.     Shafirovich, Vladimir; Dourandin, Alexander; Huang, Weidong; Luneva, Natalia P.; Geacintov, Nicholas E.    Chemistry Department and Radiation and Solid State Laboratory,  New York University,  New York,  NY,  USA.    Journal of Physical Chemistry B  (1999),  103(49),  10924-10933.  CODEN: JPCBFK  ISSN: 1089-5647. 

Multiphoton near-infrared femtosecond laser pulse-induced DNA damage with and without the photosensitizer proflavine.     Shafirovich, Vladimir; Dourandin, Alexander; Luneva, Natalia P.; Singh, Carolyn; Kirigin, Francis; Geacintov, Nicholas E.    Chemistry Department and Radiation and Solid State Laboratory,  New York University,  New York,  NY,  USA.    Photochemistry and Photobiology  (1999),  69(3),  265-274. 

Photoinduced electron transfer and strand cleavage in pyrenyl-DNA complexes and adducts.     Geacintov, Nicholas E.; Solntsev, Kyril; Johnson, Lawrence W.; Chen, Junxin; Kolbanovskiy, Alexander D.; Liu, Tongming; Shafirovich, Vladimir Ya..    Chemistry Department,  New York University,  New York,  NY,  USA.    J. Phys. Org. Chem.  (1998),  11(8/9),  561-565. 

Long-range transfer of reactive intermediate species in photoexcited, site-specific photosensitizer-modified DNA.     Huang, W.; Liu, T. M.; Dourandin, A.; Shafirovich, V.; Geacintov, N. E.    Chemistry Department,  New York University,  NY,  USA.    Book of Abstracts, 216th ACS National Meeting, Boston, August 23-27  (1998),     TOXI-029.  Publisher: American Chemical Society,  Washington, D. C  CODEN: 66KYA2  Conference; Meeting Abstract  written in English.    AN 1998:529896    CAPLUS   (Copyright 2002 ACS) 

Role of Hydrophobic Effects in the Reaction of a Polynuclear Aromatic Diol Epoxide with Oligodeoxynucleotides in Aqueous Solutions. Pirogov, Nikolai; Shafirovich, Vladimir A.; Kolbanovskiy, Alexander; Solntsev, Kyril; Courtney, Scott A.; Amin, Shantu; Geacintov, Nicholas E., Chem. Res. Toxicol.  (1998),  11(4),  381-388.

Migration and Trapping of Photoinjected Excess Electrons in Double-Stranded B-Form DNA But Not in Single-Stranded DNA.     Shafirovich, Vladimir Ya.; Dourandin, Alexander; Luneva, Natalia P.; Geacintov, Nicholas E.    Chemistry Department and Radiation and Solid State Laboratory,  New York University,  New York,  NY,  USA.    J. Phys. Chem. B  (1997),  101(30),  5863-5868. 

Monitoring of molecular dynamics in lipid bilayers of small unilamellar vesicles by magnetic-field-sensitive probes. Shafirovich, Vladimir Ya.; Batova, Elena E.; Levin, Peter P., J. Am. Chem. Soc.  (1995),  117(22),  6093-6100.

Proton-Coupled Photoinduced Electron Transfer, Deuterium Isotope Effects, and Fluorescence Quenching in Noncovalent Benzo[a]pyrenetetraol-Nucleoside Complexes in Aqueous Solutions. Shafirovich, Vladimir Ya.; Courtney, Scott H.; Ya, Naiqi; Geacintov, Nicholas E., J. Am. Chem. Soc.  (1995),  117(17),  4920-4929.

Influence of Adduct Stereochemistry and Hydrogen-Bonding Solvents on Photoinduced Charge Transfer in a Covalent Benzo[a]pyrene Diol Epoxide-Nucleoside Adduct on Picosecond Time Scales. O'Connor, Donald; Shafirovich, Vladimir Y.; Geacintov, Nicholas E., J. Phys. Chem.  (1994),  98(39),  9831-9839.

Photoinduced electron transfer and enhanced triplet yields in benzo[a]pyrene derivative-nucleic acid complexes and covalent adducts. Shafirovich, Vladimir Ya.; Levin, Peter P.; Kuzmin, Vladimir A.; Thorgeirsson, Thorgeir E.; Kliger, David S.; Geacintov, Nicholas E., J. Am. Chem. Soc. (1994),  116(1),  63-72.

Extreme viscosity dependence for the magnetic-field-sensitive recombination rates of chain-linked triplet radical ion pairs. Shafirovich, Vladimir Ya.; Batova, Elena E.; Levin, Peter P., J. Phys. Chem.  (1993),  97(19),  4877-4879.