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KATHARINE
C. COLGATE
HIGHLIGHTS
 | Extensive
experience in giving scientific presentations.
|
| Extensive
experience in HPLC separations, Mass Spectrometry, Circular Dichroism,
Absorption and Fluorescence Spectrometry.
|
| Extensive
experience in method development and method validation.
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| Strong
background in biochemical skills.
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| Strong
background in the study of carcinogenesis.
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| Strong
background in clinical trials and data management.
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EDUCATION
| PhD
in Biochemistry, New York University, New York, NY
8/2003
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| MS
in Chemistry, New York University, New York, NY
5/2000
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| MS
in Biology, New York University, New York, NY
5/1998
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| BS
in Chemistry, Bates College, Lewiston, ME
5/1996
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| Westminster
School, Simsbury, CT
5/1992
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PROFESSIONAL
EXPERIENCE
Ø
Graduate
Research Assistant, New York
University, (New York, NY) 1998-present.
DNA Chemistry
and Photophysics Laboratory
| Synthesis,
identification, and characterization of DB[a]P-dG adducts.
|
| Studies
of nucleic acid excision repair (NER) of structurally different DNA adducts
caused by environmental carcinogens that effect the p53 Gene causing
“hotspots” of mutation.
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Ø
Graduate
Research Assistant, New York
University, (New York, NY) 1997-1998.
Laboratory of Neuroplasticity
and the Center for Aging
| The
study of serotonin levels (5HT-1A receptor activity) caused by the S100B
protein in the cortex cells of prenatal rat brain, and how these level may
contribute to the onset of Alzheimer’s disease.
|
Ø
Teacher’s
Assistant in Chemistry, New
York University, (New York, NY) 1997-2000.
| Prepared
and taught lecture and laboratory classes to under-graduate pre-medical
students.
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Ø
Research
Study Assistant and Data Manager in the Clinical Trials Department, Memorial Sloan Kettering Cancer Center, (New York, NY) 1996-1997.
| In
charge of certain clinical trials for experimental cancer fighting drugs for
the gastrointestinal service, which included phase II, and III clinical
trials.
|
Ø
Internship
in Protein Chemistry, The
Cold Spring Harbor Laboratory, (Cold Spring Harbor, NY) Summer 1996.
| Learned
techniques in peptide synthesis and combinatorial chemistry to identify
cancer specific proteins.
|
Ø
Student
Athletic Sports Medicine Trainer, Bates
College, (Lewiston, ME) 1992-1996.
| Evaluation
and care of athletic injuries.
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SKILLS
| HPLC
(Waters 501, 510, and 515 with DAD; Hitachi L-6200A)
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| UV-VIS
(HP 8451A; AVIV 14DS; Agilent 8453; Perkin-Elmer LC-15; Hitachi L4000;
Shimadzu SPD-10A)
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| Circular
Dichroism Spectrometer (AVIV 202SF)
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| Mass
Spectrometer (Bruker Daltonics OmniFLEX Maldi Tof)
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| Fluorescence
Spectrometer (Hitachi F-2500; HP series 100; Perkin-Elmer LS-5 and 650S)
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| Gel
electrophoresis (DNA purification and sequencing
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| Cell
culture techniques (HeLa, lymphoblast, and neural cells)
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| In
vivo and in vitro
DNA repair assays
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| Protein
extraction from human cells
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PROFESSIONAL
MEMBERSHIPS
| American
Chemical Society
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| The
New York Academy of Sciences
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| American
Association for Cancer Research
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COMPUTER
SKILLS
| Proficient
in Microsoft Office, Adobe Photoshop, Micro Origin, Phosphor Analyst, Image
Quant, ChemDraw, Scifinder, End-Note, Spartan Software for molecular
modeling and quantum mechanical calculations, CRDB, Oracle, Internet and
World Wide Web connectivity, and other computer packages for chemists in
Microsoft windows (98, NT, 2000, XP).
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PUBLICATIONS
| Huang,
Xuanwei; Colgate, Katharine C.; Kolbanovskiy, Aleksandr; Amin, Shantu;
Geacintov, Nicholas E. “ Confomational Changes of a Benzo[a]pyrene
Diol epoxide-N2-dG Adduct Induced by a 5’-flanking 5-Methyl
Substituted Cytosine in a MeCG Double-Stranded Oligonucleotide Sequence
Context”, Chemical Research in
Toxicology, 15(3), 438-444 (2002).
|
| Muheim,
Regula; Bolhalder, Maja; Buterin, Tonko; Colgate, Katharine C.; Kolbanovskiy,
Aleksandr; Geacintov, Nicholas E.; and Neigeli, Hanspeter,
“ Modulation of Human Nuclotide Excision Repair by
5-methylcytosines”, to be published in Cancer
Research.
|
Presentations
and Published Abstracts from Scientific Conferences
| Colgate,
Katharine C; Huang, Xuanwei; Kolbanovisky, Aleksandr; Amin, Shantu;
Geacintov, Nicholas E. “ Molecular spectroscopic analysis of
conformational changes induced by 5-MeC Groups adjacent to Benzo[a]pyrene
diol epoxide N2-dG Adducts at
p53 mutational hot spot 5-MeCG* Oligonucleotide Sequences”. 222nd
American Chemical Society National Meeting. August 2001, Chicago, IL.
|
| Huang,
Xuanwei; Colgate, Katharine C.; Kolbanovskiy, Aleksandr; Amin, Shantu;
Geacintov, Nicholas E. “ Confomational Changes of a Benzo[a]pyrene
Diol epoxide-N2-dG Adduct Induced by a 5’-flanking 5-Methyl
Substituted Cytosine in a MeCG Double-Stranded Oligonucleotide Sequence
Context”. American Association for
Cancer Research Conference, March 2002, San Francisco, CA.
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Volunteer
Experience
| Board
member of “Street Project”, a New York based non-profit organization for
the homeless.
|
| English,
Science and Math tutor. St.Mary’s
Hospital, Lewiston, ME.
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| Figure
Skating Instructor for children and adults, Bates
College, Lewiston, ME.1994-1996.
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Interests
and Activities
| Sailing,
skiing, tennis, golf, yoga and long distance running.
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| Sailing
coach at various Yacht Clubs on the east coast (summers 1993, 1994,1995)
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| Founder
and Captain of the Bates College women’s ice hockey team, varsity
cross-country team member.
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Recent
Publications
Projects
Instrumentation