Ph.D. (2001), University of Dublin, Trinity College, Ireland.

 B.A.    (1997), University of Dublin, Trinity College, Ireland.

Research Interests: 

Oxidative damage to DNA, Mechanistic and structural studies.

Recent Publications:

1.            C.W.Crean, Y.T Kavanagh,, C. O'Keefe,M.P. Lawler, C. Stevenson, R.J.H Davies, P.H. Boyle, J.M. Kelly, Journal of Photochemical and Photobiological Sciences, 2002, 12, 1024.

2.         R. Misiasek, C.Crean, V. Shafirovich and N.E. Geacintov, Oxidative damage associated with combination of Guanine and superoxide radicals and repair mechanisms via radical trapping., Journal of Biological Chemistry, 2004, 279, 32106.

3.         C.W. Crean, R. Camier, M.P. Lawler, C. Stevenson, R.J.H. Davies, P.H. Boyle and J.M. Kelly, Synthesis of N3-and 2-NH₂-substituted 6,7-diphenylpterins and their use as intermediates for the preparation of oligonucleotide conjugates designed to target photooxidative damage on single stranded DNA representing the bcr-ablchimeric gene. Organic and Biomolecular Chemistry, 2004, 2(24), 3588.

4.         R. Misiasek, C.Crean, V. Shafirovich and N.E. Geacintov. Combination of Nitrogen Dioxide Radicals with 8-oxo-7,8-dihydroguanine radicals in DNA: Oxidation and Nitration end products. Journal of the American Chemical Society, 2005, 127, 2191

5.         R. Misiaszek, Y.Uvaydov, C. Crean, N.E. Geacintov, and V. Shafirovich, Combination reactions of superoxide with 8-Oxo-7,8-dihydroguanine radicals in DNA: kinetics and end-products. Journal of Biological Chemistry, 2005, 8, 6293

6.         C. Crean, N.E. Geacintov and V. Shafirovich, Oxidation of Guanine and 8-oxo-7,8-dihydroguanine by carbonate radical anions: Insights from ¹⁸O labeling experiments. . Angewandte Chemie, Int. Ed. 2005,44, 5057

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