The major interests of the laboratory are on  DNA damage caused by environmental polynuclear aromatic cancer-causing contaminants and endogenous free radical intermediates that are overproduced in humans at sites of inflammation.   The focus of our studies is on mechanisms of formation of DNA lesions, their stereochemical and structural properties, and their  repair by the well known multi-tasking cellular defense mechanism called nucleotide excision repair.


A polynuclear aromatic hydrocarbon metabolite lesions (in red) embedded in DNA in a nucleosome, the fundamental building block of chromatin.

(Courtesy Y. Cai and S. Broyde