Desplan Lab
New York University. 100 Washington Square East.
1009 Silver Center. New York, NY. 10003.

Lab Publications

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2016 [TOP]

  • Neriec N, Desplan C.
    From the Eye to the Brain: Development of the Drosophila Visual System.
    Current Topics in Dev Bio doi:10.1016/bs.ctdb.2015.11.032 (2016).
  • Payre F, Desplan C.
    RNA. Small peptides control heart activity.
    Science Jan 15;351(6270):226-7. doi: 10.1126/science.aad9873. PMID: 26816363 (2016).
  • Simola DF, Graham RJ, Brady CM, Enzmann BL, Desplan C, Ray A, Zwiebel LJ, Bonasio R, Reinberg D, Liebig J, Berger SL.
    Epigenetic (re)programming of caste-specific behavior in the ant Camponotus floridanus.
    Science Jan 1;351(6268):aac6633. doi: 10.1126/science.aac6633. PMID: 26722000 (2016).

2015 [TOP]

  • Rister J, Razzaq A, Boodram P, Desai N, Tsanis C, Chen H, Jukam D, Desplan C.
    Single-base pair differences in a shared motif determine differential Rhodopsin expression.
    Science Dec 4;350(6265):1258-61. doi: 10.1126/science.aab3417. PMID: 26785491 (2015).
  • Wernet MF, Desplan C.
    Brain Wiring in the Fourth Dimension.
    Cell Jul 2;162(1):20-2. doi: 10.1016/j.cell.2015.06.040. PMID: 26140589 (2015).
  • Fernandes VM, Desplan C.
    Neurobiology: Inversion in the worm.
    Nature Jul 2;523(7558):44-5. doi: 10.1038/523044a. PMID: 26135446 (2015).
  • Wernet MF, Perry MW, Desplan C.
    The evolutionary diversity of insect retinal mosaics: common design principles and emerging molecular logic.
    Trends in Genetics May 26. pii: S0168-9525(15)00081-5. PMID: 26025917 (2015).
  • Courgeon M, Konstantinides N, Desplan C.
    Cell competition: dying for communal interest.
    Current Biology Apr 20;25(8):R339-41. PMID: 25898106 (2015).
  • Behnia R, Desplan C.
    Visual circuits in flies: beginning to see the whole picture.
    Curr Opin Neurobiol. Apr 13;34:125-132. PMID: 25881091 (2015).
  • Konstantinides N, Rossi AM, Desplan C.
    Common temporal identity factors regulate neuronal diversity in fly ventral nerve cord and mouse retina.
    Neuron Feb 4;85(3):447-9. PMID: 25654249 (2015).

2014 [TOP]

  • Wernet MF, Huberman AD, Desplan C.
    So many pieces, one puzzle: cell type specification and visual circuitry in flies and mice.
    Genes and Development Dec 1;28(23):2565-84. PMID: 25452270 (2014).
  • Behnia R, Clark D, Carter A, Clandinin T, Desplan C.
    Processing properties of ON and OFF pathways for Drosophila motion detection.
    Nature Aug 28;512(7515):427-30. PMID: 25043016 (2014).
  • Bertet C, Li X, Erclik T, Cavey M, Wells B, Desplan C.
    Temporal Patterning of Neuroblasts Controls Notch-Mediated Cell Survival through Regulation of Hid or Reaper.
    Cell Aug 28, 158(5):1173-86. PMID: 25171415 (2014).
  • Johnston RJ Jr, Desplan C.
    Interchromosomal communication coordinates intrinsically stochastic expression between alleles.
    Science Feb 7;343(6171):661-5. PMID: 24503853 (2014).
  • Pinto-Teixeira F, Desplan C.
    Notch activity in neural progenitors coordinates cytokinesis and asymmetric differentiation.
    Science Signaling Oct 21;7(348):pe26. PMID: 25336612 (2014).
  • Nathalie Neriec and Claude Desplan
    Different ways to make neurons: parallel evolution in the SoxB family.
    Genome Biology 15:116. doi:10.1186/gb4177 (2014).
  • Wernet MF, Meier KM, Baumann-Klausener F, Dorfman R, Weihe U, Labhart T, Desplan C.
    Genetic Dissection of Photoreceptor Subtype Specification by the Drosophila melanogaster Zinc Finger Proteins Elbow and No ocelli.
    PLoS Genetics Mar 13;10(3):e1004210. PMID: 24625735 (2014).
  • Rosenberg MI, Brent AE, Payre F, Desplan C.
    Dual mode of embryonic development is highlighted by expression and function of Nasonia pair-rule genes.
    ELife Mar 5;3:e01440. PMID: 24599282 (2014).
  • Wernet MF, Desplan C.
    Homothorax and Extradenticle alter the transcription factor network in Drosophila ommatidia at the dorsal rim of the retina.
    Development Feb;141(4):918-28. PMID: 24496628 (2014).

2013 [TOP]

  • Wernet MF, Desplan C.
    Sensory cell fates: four defaults for the price of one.
    Current Biology Dec 16;23(24). PMID: 24355782 (2013).
  • Li X, Chen Z, Desplan C.
    Temporal patterning of neural progenitors in Drosophila.
    Current Topics in Developmental Biology 05:69-96. PMID: 23962839. (2013).
  • Perry M, Desplan C.
    Opposing feedbacks on ras tune receptor tyrosine kinase signaling.
    Science Signaling Nov 5;6(300):pe35. PMID: 24194582. (2013).
  • Morante J, Vallejo DM, Desplan C, Dominguez M.
    Conserved miR-8/miR-200 Defines a Glial Niche that Controls Neuroepithelial Expansion and Neuroblast Transition.
    Developmental Cell Oct 28;27(2):174-87. PMID: 24139822. (2013).
  • Jukam D*, Xie B*, Rister J*, Terrell D, Charlton-Perkins M, Pistillo D, Gebelein B, Desplan C, Cook T.
    Opposite Feedbacks in the Hippo Pathway for Growth Control and Neural Fate.
    Science Oct 11;342(6155) PMID: 23989952. (2013). *These authors contributed equally.
  • Hsiao HY, Jukam D, Johnston R, Desplan C.
    The neuronal transcription factor Erect wing regulates specification and maintenance of Drosophila R8 photoreceptor subtypes.
    Developmental Biology. PMID: 23850772. (2013).
  • Li X, Erclik T, Bertet C, Chen Z, Voutev R, Venkatesh S, Morante J, Celik A, Desplan C.
    Temporal patterning of Drosophila medulla neuroblasts controls neural fates.
    Nature. Jun 27;498(7455):456-62. PMID: 23783517. (2013).
  • Thanawala SU, Rister J, Goldberg GW, Zuskov A, Olesnicky EC, Flowers JM, Jukam D, Purugganan MD, Gavis ER, Desplan C, Johnston RJ Jr.
    Regional modulation of a stochastically expressed factor determines photoreceptor subtypes in the Drosophila retina.
    Developmental Cell. Apr 15;25(1):93-105. PMID: 23597484. (2013).
  • Pinto-Teixeira F, Desplan C.
    Dying to entrain: regulating ipRGC spacing.
    Developmental Cell. Feb 25;24(4):338-40. PMID: 23449468. (2013).
  • Rister J, Desplan C, Vasiliauskas D.
    Establishing and maintaining gene expression patterns: insights from sensory receptor patterning.
    Development 140(3) 493-503. doi:10.1242/dev.079095. (2013).

2012 [TOP]

  • Hsiao H. Y.*, Johnston Jr. R. J.*, Jukam D.*, Vasiliauskas D.*, Desplan C., Rister J.
    Dissection and Immunohistochemistry of Larval, Pupal and Adult Drosophila Retinas.
    J. Vis. Exp. (69), e4347, doi:10.3791/4347 (2012). *These authors contributed equally. VIEW WEB VIDEO PROTOCOL
  • Chen Z, Li X, Desplan C.
    Deterministic or stochastic choices in retinal neuron specification.
    Neuron vol. 75 (5) pp. 739-42 (2012). PMID: 22958814

2011 [TOP]

  • del Valle Rodriguez A.,Didiano D., & Desplan C.
    Power tools for gene expression and clonal analysis in Drosophila.
    Nature Methods 9(1) 47-55 (2011). PMID: 22205518.
  • Morante J., Erclik T., & Desplan C.
    Cell migration in Drosophila optic lobe neurons is controlled by eyeless/Pax6.
    Development 138 687-93 (2011). PMCID: PMC3026414.
  • Johnston R. Jr., Otake Y., Sood P., Vogt N., Behnia R., Vasiliauskas.D, McDonald E., Xie B., Koenig ., Wolf R., Cook T., Gebelein B., Kussell ., Nagakoshi H. & Desplan C.
    Interlocked feedforward loops control specific Rhodopsin expression in the Drosophila eye.
    Cell, 145 956-68 (2011). PMCID: PMC21663797.
  • Vasiliauskas D., Mazzoni E., Johnston R., Sprecher S., Vogt N., Lidder P. & Desplan C.
    Feedback from Rhodopsin protein controls rhodopsin exclusion in Drosophila R8 photoreceptors.
    Nature, 479(7371) 108-12 (2011). PMID: 21983964.
  • Jukam D.M. & Desplan C.
    Binary Regulation of Hippo Pathway by Merlin/NF2, Kibra, Lgl, and Melted Specifies and Maintains Postmitotic Neuronal Fate.
    Dev Cell, 21(5) 874-87 (2011). PMID: 22055343.
  • Lynch J.A. Özüak O., Khila A., Abouheif E., Desplan C. & Roth S.
    The phylogenetic origin of oskar coincided with the origin of maternally provisioned germ plasm and pole cells at the base of the Holometabola.
    PLoS Genetics, 7(4) (2011). PMID:21552321.
  • Keene, A, Mazzoni, E.O. Zhena, J., Younger M.A., Yamaguchi S., Blau J., Desplan C. & Sprecher S.G.
    Distinct visual pathways mediate Drosophila larval light avoidance and circadian clock entrainment.
    J. Neuroscience, 31 6527-34 (2011). PMCID: PMC21525293.
  • Rister J., & Desplan C.
    The retinal mosaics of opsin expression in invertebrates and vertebrates.
    Develop. Neurobiol., 71(12) 1212-26 (2011). PMID: 21557510.

2010 [TOP]

  • Buckingham M. & Desplan C.
    Developmental mechanisms, patterning and evolution.
    Current Op. Genetics & Devel. 20, 1–3 (2010). NIHMSID # 218634.
  • Johnston, R. J. Jr. & Desplan C.
    A Penetrating look at stochasticity in development.
    Cell 140, 610-612 (2010). PMCID: PMC2848716.
  • Johnston, R.J. Jr. & Desplan C.
    Stochastic mechanisms of cell fate specification that yield random or robust outcomes.
    Annu. Rev. Cell. Dev. Biol. 26, 16.1–16.31 (2010). PMCID: PMC3025287.
  • Jukam, D. & Desplan C.
    Binary fate decisions in differentiating neurons.
    Current Op. Neurobiol. 20, 6–13 (2010). PMCID: PMC2827633.
  • Keller, R.G., Desplan C. & Rosenberg M.I.
    Identification and characterization of Nasonia Pax genes.
    Insect Mol. Biol. 1, 109-120 (2010). PMCID: PMC2852259.
  • Lynch J.A. & Desplan C.
    Novel modes of localization and function of nanos in the wasp Nasonia.
    Development 137, 3813-21 (2010). PMCID: PMC3049278.
  • Morante J. & Desplan C.
    A protocol for dissecting and staining Drosophila optic lobes In "Drosophila Neurobiology: A Laboratory Manual".
    Eds: B. Zhang; M. Freeman& S. Waddell, CSH Press, 157-160 (2010). Book Chapter: No PMCID.
  • Rister, J. & Desplan C.
    Deciphering the genome's regulatory code: The many languages of DNA.
    BioEssays 32, (5) (2010). PMCID: PMC3024831.
  • Rosenberg M.I., & Desplan C.
    Hiding in Plain Sight.
    Science 329, 284-285 (2010). PMCID: PMC3033778.
  • Vogt N. & Desplan C.
    Flipping the light switch.
    Science 330, 454-5 (2010). PMCID: PMC2633596.
  • Werren J., Richards S., Desjardins C., Niehuis O, Gadau J, Colbourne J, Beukeboom L., Desplan C. et al.
    Functional and evolutionary insights from the genomes of three parasitoid Nasonia species.
    Science, 327, 343-8 (2010). PMCID: PMC2849982.
  • Yamaguchi, S., Desplan C. & Heisenberg M.
    Contribution of photoreceptor subtypes to spectral wavelength preference in Drosophila.
    Proc. Natl. Acad. Sci. USA 107, 5634-9 (2010). PMCID: PMC2851746.

2009 [TOP]

  • Griffin R, Sustar A, Bonvin M, Binari R, del Valle Rodriguez A, Hohl AM, Bateman JR, Villalta C, Heffern E, Grunwald D, Bakal C, Desplan C, Schubiger G, Wu CT, Perrimon N.
    The twin spot generator for differential Drosophila lineage analysis.
    Nature Methods 6, 600-602 (2009). PMCID: PMC2720837.
  • Vasiliauskas D, Johnston R.J. Jr, & Desplan C.
    Maintaining a stochastic neuronal cell fate decision.
    Genes Dev. 23, 385-90 (2009). NIHMSID #263956.
  • Sprecher S.G., & Desplan C.
    Development of the Drosophila eye, from precursor specification to terminal differentiation.
    "Animal models for eye research". Elsevier, 27-47 (2009).
  • Rosenberg M.I., Lynch J.A. & Desplan C.
    Heads and tails: Evolution of antero-posterior patterning in insects.
    Biochem Biophys Acta 1789, 333-42 (2009). PMCID: PMC2700975.
  • Desplan, C.
    Les sens au gré du hasard.
    Pour La Science (French Sci. Amer.) 385 88093 (2009).

2008 [TOP]

  • Sprecher, S.G., & Desplan C.
    Switch of rhodopsin expression in terminally differentiated Drosophila sensory neurons.
    Nature 454, 533-537 (2008). PMCID: PMC2750042.
  • Mazzoni, E, Celik, A., Wernet, M, Vasiliauskas, D., Cook, T, Johnston, R.J., Pichaud, F. & Desplan C.
    Iroquois-Complex genes induce co-expression of visual pigments in Drosophila.
    PLoS Biology 6, e97,825-835 (2008). PMCID: PMC2323304. [Primer ]
  • Johnston R.J. Jr & Desplan C.
    Stochastic neuronal cell fate choices.
    Curr Opin Neurobiol. 18, 20-27 (2008). PMCID: PMC2478740.
  • Yamaguchi, S., Wolf, R., Desplan C., & Heisenberg M.
    Motion vision is independent of color in Drosophila.
    Proc. Natl. Acad. Sci. USA 105, 4910-4915 (2008). PMCID: PMC2290790.
  • Morante J., & Desplan C.
    The color-vision circuit in the medulla of Drosophila.
    Current Biology 18, 553-565 (2008). PMCID: PMC2430089. [Published Comment ]
  • Losick R. & Desplan C.
    Stochastic choices and cell fate.
    Science 320, 65-68 (2008). PMCID: PMC2605794.
  • Rosenberg M.I. & Desplan C.
    Patterning lessons from a dorsalized embryo.
    Dev Cell 14, 455-6 (2008). PMCID: PMC3023818.

2007 [TOP]

  • Vogt N. & Desplan C.
    The first steps in Drosophila motion detection.
    Neuron 56, 5-7 (2007). PMCID: PMC2633596.
  • Wernet, M. F. Çelik, A., Mikeladze-Dvali T., & Desplan C.
    Generation of uniform fly retinas.
    Current Biol. 17: R1002-1003 (2007).
  • Desplan C.
    Time to pick the fly's brain.
    Nature 450; 173. (2007).
  • Brent A.E., Yucel G., Small S. & Desplan C.
    Permissive and instructive anterior patterning functions rely on mRNA localization in the wasp embryo.
    Science 315, 1841-1843 (2007).
  • Sprecher S. G, Pichaud, F. & Desplan C.
    Adult and larval photoreceptors use different mechanisms to specify the same Rhodopsin fates.
    Genes & Devel. 21, 2182-2195 (2007). PMCID: PMC1950857.
  • Olesnicky, E. C. & Desplan C.
    Distinct mechanisms for mRNA localization during embryonic axis specification in the wasp Nasonia.
    Dev. Biol. 306, 134-142 (2007). PMCID: PMC1973164.
  • Morante J., Desplan C. & Celik A.
    Generating patterned arrays of photoreceptors.
    Current Op. Gen. & Dev. 37-48 (2007). PMCID: PMC2713430.
  • Olesnicky, E C. & Desplan C.
    Gaining New Insights into primitive strategies for embryonic axis specification using the wasp Nasonia.
    Funct. Devel. Embryol, 1, (2007).
  • Fuss S., Çelik A. & Desplan C.
    Olfactory identity kicked-up a Notch.
    Nature Neurosc. 10, 138-140 (2007).

2006 [TOP]

  • Wernet M. F., Mazzoni E. O., Çelik A, Duncan D. M., Duncan I. & Desplan C.
    Stochastic expression of spineless creates the retinal mosaic for color vision.
    Nature 440, 174-180 (2006). Article.
  • Lynch J.A., Brent A.E., Leaf D.S., Pultz M.A. & Desplan C.
    Localized maternal orthodenticle patterns anterior and posterior in the long germ wasp Nasonia.
    Nature 439, 728-732 (2006).
  • Lynch J.A. & Desplan C.
    Regulation and function of tailless in the long germ wasp Nasonia vitripennis.
    Dev. Genes & Evol., 216, 493-498 (2006).
  • Olesnicky E. C., Brent.A. E., Tonnes L., Walker M., Pultz M.A., Leaf D. & Desplan C.
    A caudal mRNA gradient controls posterior development in the wasp Nasonia.
    Development 133, 3973-3982 (2006).
  • Lynch J.A. & Desplan C.
    A method for parental RNA interference in the wasp Nasonia vitripennis.
    Nature Protocols 1, 486-494 (2006).

2005 [TOP]

  • Mikeladze-Dvali T., Wernet M., Pistillo D. , Mazzoni E. O., Teleman A., Chen Y., Cohen S. & Desplan C.
    The growth regulators Warts/lats and Melted interact in a bistable loop to specify opposite fates in R8 photoreceptors.
    Cell 122, 775-787 (2005). Featured in Dev. Cell, Current Biology & Nature Rev. Neuro.
  • Mazzoni E, Desplan C. & Blau J.
    Circadian pacemaker neurons transmit and modulate information to control a rapid behavioral response.
    Neuron 45, 293-300 (2005).
  • Pultz MA, Westendorf L, Gale S, Hawkins K, Lynch J, Pitt J., Reeves N, Yao J, Small S, Desplan C. & Leaf D.
    A major role for zygotic hunchback in patterning the Nasonia embryo.
    Development 132, 3705-15 (2005).
  • Mikeladze-Dvali T., Desplan C. & Pistillo D.
    Flipping coins in the fly retina.
    Current Topics in Dev. Biol. 69, 1-15 (2005).
  • Morante J. & Desplan C.
    Photoreceptors play hide and seek.
    (News & Views) Nature Neuroscience 8, 401-402 (2005).

2004 [TOP]

  • Wernet M.F. & Desplan C.
    Building a retinal mosaic: cell-fate decision in the fly eye.
    Trends Cell Biol. 14 , 576-584 (2004).
  • Mazzoni E, Desplan C. & Celik A.
    "One receptor" rules in sensory neurons.
    Devel. Neuro. 26, 388-395 (2004).
  • Morante J. & Desplan C.
    Building a projection map for photoreceptor neurons in the Drosophila optic lobes.
    Semin. Cell. Dev. Biol. 15, 137-43 (2004).
  • Desplan C.
    Doit-on choisir entre liberté et ambition?
    Commentaire. 107, 620-625 (2004).

2003 [TOP]

  • Wernet M., Labhart T., Baumann F., Mazzoni E., Pichaud F. & Desplan C.
    Homothorax switches function of Drosophila photoreceptors from color to polarized light sensors.
    Cell 115, 267-279 (2003).
  • Tahayato A., Sonneville R., Pichaud F., Papatsenko D., Beaufils P., Wernet M., Cook T. & Desplan C.
    Otd/Crx, a dual regulator for the specification of ommatidia subtypes in the Drosophila retina.
    Dev. Cell 5, 391-402 (2003).
  • Cook T., Pichaud F., Sonneville R, Papatsenko D. & Desplan C.
    Distinction between color photoreceptor cell fates is controlled by prospero in Drosophila.
    Dev. Cell 4, 853-864 (2003). Cover picture.
  • Jang C. , Chao J., Jones N., Yao L., Bessarab D., Kuo Y., Jun S., Desplan C. Beckendorf S. & Sun Y. H.
    Two Pax genes, eye gone and eyeless, act cooperatively in promoting Drosophila eye development.
    Development 130, 2939-2951 (2003).
  • Lynch J. & Desplan C.
    Evolution of Development: Beyond Bicoid.
    Current Biology 13, R557-559 (2003).
  • Desplan C. & Lecuit T.
    Flowers' wings and flies' petals.
    (News & Views) Nature 422, 123-124 (2003).
  • Beukeboom L. & Desplan C.
    Quick guide: Nasonia.
    Current Biology 13, R860 (2003).
  • Lynch J. & Desplan C.
    'De-evolution' of Drosophila toward a more generic mode of axis patterning.
    Int. J. Dev. Biol., 7, 497-503 (2003).

2002 [TOP]

  • Papatsenko D. Makeev V., Lifanov A, Régnier M.,Nazina A. & Desplan C.
    Extraction of functional binding sites from unique regulatory regions: The Drosophila early developmental enhancers.
    Genome Res. 12, 470-481 (2002). PMCID: PMC155290.
  • Pichaud F & Desplan C.
    Pax genes and eye organogenesis.
    Curr. Opin. Genet. Dev., 12, 430-434 (2002).
  • Pichaud F & Desplan C.
    A new view of photoreceptors.
    (News & Views) Nature 416, 139-140 (2002).
  • Pichaud F & Desplan C.
    Science, 295, (2002) Cover only.
  • Pichaud F & Desplan C.
    Evolution of color vision.
    Results and Problems in Cell Differentiation K. Moses Ed. Springer-Verlag Berlin, 37, 135-149 (2002).

2001 [TOP]

  • Mollereau B., Dominguez M., Webel R., Colley N., Keung B., de Celis J., & Desplan C.
    Two-step process for photoreceptor formation in Drosophila.
    Nature 412, 911-913 (2001).
  • Pichaud F & Desplan C.
    A new visualization approach for identifying mutations that affect differentiation and organization of the Drosophila ommatidia.
    Development 128, 815-826 (2001). Cover picture.
  • Pichaud F, Treisman J. & Desplan C.
    Reinventing a common strategy for patterning the eye.
    Cell 105, 9-12 (2001).
  • Cook T. & Desplan C.
    Photoreceptor subtype specification: from flies to humans.
    Semin. Cell Dev. Biol., 12, 509-518 (2001).
  • Papatsenko D., Nazina A. & Desplan C.
    A conserved regulatory element present in all Drosophila Rhodopsin genes mediates Pax6 functions and participates in the fine-tuning of cell-specific expression.
    Mech. Devel. 101, 143-153 (2001).

2000 [TOP]

  • Schaeffer V., Killian D., Desplan C. & Wimmer E.
    High bicoid levels render the terminal system dispensable for Drosophila head development.
    Development 127, 18, 3993-3999 (2000).
  • Wimmer E., Carleton A., Harjes P., Turner T. & Desplan C.
    Bicoid-independent formation of thoracic segments in Drosophila.
    Science 287, 2476-2479 (2000).
  • Janody F., Sturny R., Catala F., Desplan C. & Dostatni N.
    Phosphorylation of Bicoid on MAP-Kinase sites: contribution to its interaction with the torso pathway.
    Development 127, 279-289 (2000).
  • Mollereau B., Wernet M., Beaufils P., Killian D., Pichaud F., Kühnlein R. & Desplan C.
    A GFP enhancer trap in Drosophila photoreceptor cells.
    Mech. Devel., 93 151-160 (2000). Cover picture.

1999 [TOP]

  • Pichaud F., Briscoe A & Desplan C.
    Evolution of color vision.
    Current Opinion in Neurobiology 9 622-627 (1999).
  • Wimmer E. & Desplan C.
    Bicoid, an anterior morphogen.
    Encyclopedia of Molecular Biology, J. Wiley & Sons, Inc., New York, 1, 276-279 (1999).
  • Goriely A, Mollereau B, Coffinier C. & Desplan C.
    Munster, a novel Paired-class homeobox gene specifically expressed in the Drosophila larval eye.
    Mech. Devel., 88 107-110 (1999).
  • Desplan C.
    A View from Switzerland (Book Review).
    Science, 283, 799 (1999).
  • Wilson D. & Desplan C.
    Structural basis of Hox specificity.
    Nature Struct. Biol., 6, 297-300 (1999).
  • Schaeffer V., Janody F., Loss C., Desplan C. & Wimmer E.
    Bicoid functions without its TATA-binding protein-associated factor interaction domains.
    Proc. Natl. Acad. Sci. USA., 96, 4461-4466 (1999). PMCID: PMC16354.

1998 [TOP]

  • Jun S., Wallen R., Goriely A., Kalionis B. and Desplan C.
    Lune/eye gone, a new Pax-like protein, uses a partial paired domain and a homeodomain for DNA recognition.
    Proc. Natl. Acad. Sci. USA, 95, 13720-13725 (1998).
  • Mailhos C., André S., Mollereau B., Goriely A., Hemmati-Brivanlou A. & Desplan C.
    Drosophila Goosecoid requires a conserved heptapeptide for repression of Paired-class homeoprotein activators.
    Development 125, 937-947 (1998).

1997 [TOP]

  • Desplan C.
    Eye development: governed by a dictator or a junta?
    Cell 91, 861-864 (1997).
  • Sheng G., Thouvenot E., Schmucker D., Wilson D. & Desplan C.
    Direct Regulation of rhodopsin1 by Pax-6/eyeless in Drosophila: Evidence for the evolutionarily conserved function of Pax-6 in photoreceptors.
    Genes Dev.,11, 1122-1131 (1997).
  • Papatsenko D., Sheng G. & Desplan C.
    A new Rhodopsin in R8 photoreceptors of Drosophila: Evidence for paired expression with Rh3 in R7 cells.
    Development 124, 1665-1673 (1997).
  • Wimmer E, Cohen S., Jäckle E. & Desplan C.
    Buttonhead does not contribute to a combinatorial code proposed for Drosophila head development.
    Development 124, 1509-1517 (1997).
  • Sheng G., Harris E., Bertuccioli C. & Desplan C.
    Modular organization of Pax/Homeodomain proteins in transcriptional regulation.
    Biol. Chem., 378, 863-872 (1997).
  • Desplan C.
    Synergism in DNA binding of paired and homeo domains in Pax protein.
    Med. Sci., 13, 147-155 (1997).

1996 [TOP]

  • Yan R., Small S., Desplan C., Dearolf C & Darnell J.
    Identification of a Stat gene that functions in Drosophila development.
    Cell 84, 421-430 (1996).
  • Goriely A, Stella M., Coffinier A., Mailhos C., Dessain S., Kessler D., & Desplan C.
    A functional homologue of goosecoid in Drosophila.
    Development 122, 1641-1650 (1996).
  • Wilson D., Sheng G., Jun S. & Desplan C.
    Conservation and diversification in homeodomain-DNA interactions: a comparative genetic analysis.
    Proc. Natl. Acad. Sci. USA, 93, 6886-6891 (1996).
  • Zeltser L., Desplan C. & Heintz N.
    Hox b-13: Colinear expression of a new Hox gene in a distant region of the Hox b cluster.
    Development 122, 2475-2484 (1996).
  • Bertuccioli C., Fasano L., Jun S., Wang S, Sheng G & Desplan C.
    In vivo requirement for the paired domain and homedomain of the paired segmentation gene product.
    Development 122, 2673-2685 (1996).
  • Jun S. & Desplan C.
    Cooperative interaction between homeodomain and paired domain.
    Development 122, 2639-2650 (1996).
  • Bellaïch Y., Bandyopadhyay R., Desplan C. & Dostatni N.
    Neither the homeodomain nor the activation domain of Bicoid is specifically required to mediate its down-regulation by the Torso receptor tyrosine kinase.
    Development 122, 3499 - 3508 (1996).

1995 [TOP]

  • Wilson D., Guenther B., Desplan C. & Kuriyan J.
    High resolution crystal structure of a Paired(PAX)-class homeodomain cooperative dimer on DNA.
    Cell 82, 709-719, (1995).
  • Xu W., Rould M., Jun S., Desplan C. & Pabo, C.
    Crystal structure of a paired domain-DNA complex at 2.5 Å resolution reveals structural basis for Pax developmental mutation.
    Cell 80, 639-650, (1995).
  • Wilson D. & Desplan C.
    Homeodomain proteins: Cooperating to be different.
    Current Biol., 5, 32-34, (1995).
  • Wimmer E., Simpson-Brose M, Cohen S, Desplan C. & Jäckle H.
    Trans- and cis-acting requirements for blastodermal expression of the head gap gene buttonhead.
    Mech. Dev. ,53, 235-246 (1995).

1994 [TOP]

  • Simpson-Brose M, Treisman J. & Desplan C.
    Synergy between the Hunchback and Bicoid morphogens is required for anterior patterning in Drosophila.
    Cell 78, 855-865 (1994).
  • Perrimon N. & Desplan C.
    Signal transduction in the early Drosophila embryo: when genetics meets biochemistry.
    T.I.B.S., 19, 509-513, (1994).

1993 [TOP]

  • Ronchi E, Treisman J., Dostatni N., Struhl G. & Desplan C.
    Down-regulation of the Drosophila morphogen Bicoid by the Torso receptor mediated signal transduction cascade.
    Cell 74, 347-355 (1993).
  • Wilson D., Sheng G., Lecuit T., Dostatni N. & Desplan C.
    Cooperative dimerization of Paired class homeodomains on DNA.
    Genes & Dev., 7, 2120-2134 (1993).

1992 [TOP]

  • Treisman J. Harris E., Wilson D. & Desplan C.
    The Homeodomain: A New Face For The Helix-Turn-Helix.
    BioEssays 14, 145-150 (1992).

1991 [TOP]

  • Treisman J., Harris E., Desplan C.
    The Paired Box encodes a second DNA binding Domain in the Paired Homeodomain Protein.
    Genes & Dev., 5, 594-604 (1991).

1990 [TOP]

  • Ohkuma Y., Horikoshi M., Roeder R., Desplan C.
    Binding site-dependent direct activation and repression of in vitro transcription by Drosophila homeodomain proteins.
    Cell 61, 475-484 (1990).
  • Ohkuma Y., Horikoshi M., Roeder R., Desplan C.
    Engrailed, a homeodomain protein, can repress in vitro transcription by competition with the TATA box-binding factor Transcription factor IID.
    Proc. Natl. Acad. Sci. USA, 87, 2289-2293 (1990).
  • Heintz N., Desplan C.
    Overview of transcription. In "Hormonal control regulation of gene transcription."
    P. Cohen and G. Folkes Eds., Elsevier Sci. Publisher B.V., 3-24 (1990).

1989 [TOP]

  • Treisman J., Gönczy P., Vashishta M., Harris E., Desplan C.
    A single amino acid can determine the specificity of homeodomain proteins.
    Cell 59, 563-562 (1989).
  • Treisman J., Desplan C.
    The Drosophila developmental gene products hunchback and Krüppel bind to the promoters of hunchback.
    Nature 341, 335-337 (1989).
  • Kassis J., Desplan C., Wright D., O'Farrell P.
    Evolutionary conservation of Homeodomain binding sites and other sequences upstream and within the major transcription unit of the Drosophila segmentation gene engrailed.
    Mol. Cell. Biol., 9, 4304-4311 (1989).

1988 [TOP]

  • Desplan C., Theis J., O'Farrell P.H.
    The sequence specificity of Homeodomain-DNA interaction.
    Cell 54, 1081-1090 (1988). PMCID: PMC2753412.

1987 [TOP]

  • Thomasset M., Desplan C., Perret C.
    9-kda Vitamin D induced Calcium Binding Protein: cloning and characterisation of a specific cDNA.
    Methods in Enzymology Cellular regulators A: Calcium and Calmodulin binding protein, 139, 337-357 (1987).
  • Thomasset M., Warembourg M., Desplan C., Perret C.
    Vitamin D dependent Calcium Binding Protein gene: cDNA cloning, mRNA distribution & regulation in the rat.
    "Steroid and Sterol Hormone Action", T.C. Spelsberg and R. Kumar eds., Martinus Nijhoff Publishing, Boston, 19, 355-370 (1987).

1986 [TOP]

  • Thomasset M., Desplan C., Warenbourg M., Perret C.
    Vitamin-D dependent 9 kda Calcium Binding Protein gene: cDNA cloning, mRNA distribution and regulation.
    Biochimie, 68, 935-940 (1986).
  • Warenbourg M.,Tranchant O., Perret C., Desplan C., Thomasset M.
    In-situ detection of Cholecalcin (Cholecalciferol induced Calcium-Binding Protein, 9-kda CaBP.) messenger RNA in the rat duodenum.
    J. Histochem. Cytochem., 34, 277-280 (1986).

1985 [TOP]

  • Desplan C., Theis J., O'Farrell P.
    The Drosophila developmental gene, engrailed, encodes a sequence specific DNA-binding activity.
    Nature 318, 630-635 (1985).
  • 0'Farrell P., Desplan C., DiNardo S., Kassis J., Kuner J.,Sher E.,
    Embryonic pattern in Drosophila: The spatial distribution and sequence specific DNA-binding of engrailed protein.
    Cold Spring Harb. Symp. Quant. Biol., 50, 235-242 (1985).
  • 0'Farrell P., Desplan C., DiNardo S., Kassis J., Kuner J., Lin E., Sher E., Theis J., Wright D.
    Molecular analysis of the involvement of the Drosophila engrailed gene in embryonic pattern formation.
    Molecular and cellular determinants of animal form, Edelman G.M. ed., Alan R. Liss, inc. New York, 31, 489-520 (1985).
  • Perret C., Desplan C.,Brehier A., Thomasset M.
    Characterisation of rat 9-kDa Cholecalcin (CaBP) mRNA using a complementary DNA. Absence of homology with 28-kDa Cholecalcin mRNA.
    Eur. J. Biochem., 148, 61-66 (1985). [HTML link]
  • Perret C., Desplan C., Thomasset M.
    Cholecalcin ( a 9-kda Cholecalciferol-induced Calcium-Binding Protein ) messenger RNA. Distribution and induction by Calcitriol in the rat digestive tract.
    Eur. J. Biochem., 150, 211-217 (1985). [HTML link]
  • Lasmoles F., Jullienne A., Desplan C.,Milhaud G.,Moukhtar M.S.
    Structure of chicken Calcitonin predicted by partial nucleotide sequence of its precursor.
    FEBS Letters 180, 113-116 (1985).

1984 [TOP]

  • Desplan C., Auffray C.,Thomasset M.
    Isolation and characterisation of genomic clones from mouse and human libraries, encoding 9K intestinal Vitamin D dependent Calcium Binding Protein.
    Endocrin control of bone and Calcium metabolism Cohn D. et al. eds., Excerpta Medica, 8A, 327-330 (1984).
  • Segond N.,Jullienne A.,Lasmoles F., Desplan C., Milhaud G.,Moukhtar M.S.
    Rapid increase of Calcitonin mRNA after acute hypercalcemia.
    Eur. J. Biochem., 139, 209-215 (1984). [HTML link]
  • Thomasset M.,Rabie A.,Parkes O., Desplan C.,Henin D., Cuisinier-Gleizes.
    Vitamin Dependent Calcium Binding Protein, a marker of Purkinje cell development.
    Dev. Pharmacol. Therapeutics, 7 sup1, 6-10 (1984).

1983 [TOP]

  • Desplan C., Thomasset M., Moukhtar M.S.
    Synthesis, molecular cloning and restriction analysis of DNA complementary to Vitamin D dependent Calcium Binding Protein from rat duodenum.
    J. Biol. Chem., 258, 2762-2765 (1983).
  • Desplan C., Heidmann O., Lillie J., Auffray C., Thomasset M.
    Sequence of rat intestinal Vitamin D-dependent Calcium Binding protein derived from cDNA clone.
    J. Biol. Chem., 258, 13502-1350-5 (1983).
  • Desplan C., Brehier A., Perret C., Thomasset M.
    Rat duodenum Calcium Binding Protein mRNA: induction by 1-25 dihydroxy-cholecalciferol.
    J. Steroid Biochem. 19, 1577-1582 (1983).
  • Thomasset M., Desplan C., Parkes O.
    Rat Vitamin D dependent Calcium Binding Protein: specificity of mRNA coding for the 7500 Mr protein from duodenum and 28000 Mr protein from kidney and cerebellum.
    Eur. J. Biochem., 129, 519-524 (1983). [HTML link]
  • Lasmoles F., Desplan C., Segond N.,Jullienne A.,Treilhou-Lahille F., Milaud G., Moukhtar M.S.
    Cell free translation of chicken Calcitonin mRNA.
    FEBS Letters 157, 100-104 (1983).
  • Desplan C., Heidmann O., Auffray C.,Thomasset M.
    Cloning of rat intestinal Vitamin D dependent CaBP and evolutionnary implications.
    Calcium Binding Protein 1983 DeBernard al.eds. Elsevier Sci. Pub. B.V., 305-306 (1983).

1982 [TOP]

  • Desplan C.
    Aspects moleculaires de la biosynthese de la Calcitonine et de ses precurseurs.
    Biochimie 64, III-VI (1982).
  • Thomasset M., Desplan C., Parkes O.
    Duodenal, renal and cerebellar Vitamin D dependent Calcium Binding Proteins in the rat. Specificity and acellular biosynthesis.
    "Vitamin D, chemical, biochemical and clinical endocrinology of calcium metabolism.", Norman A. et al. eds., De Gruyter, 197-202 (1982).

1981 [TOP]

  • Raulais D., Desplan C., Monet J.D., Boccart B., Milhaud G.
    Immunochemical and biological properties of horse Parathyroid hormone.
    P.S.E.B.M., 167, 542-546 (1981).
  • Thomasset M., Desplan C., Moukhtar M.S., Matthieu H.
    Primary translation product of mRNA coding for rat duodenal vitamin D induced Calcium Binding Protein.
    FEBS Letters 134, 178-181 (1981).
  • Vigot P.L., Polli E.E., Milhaud G., Moukhtar M.S., Desplan C., Duriez J.
    Aminoterminal Parathyroid hormone radioimmunoassay to evaluate bone status in renal failure.
    Lancet i, 443-444 (1981).
  • Raulais D., Desplan C., Monet J.D., Moukhtar M.S., Milhaud G.
    Horse Parathyrin: Immunochemical comparison with human Parathyrin.
    "Peptides 1980", Brunfelt K. ed., Scriptor pub. Aps., 768-773 (1981).

1980 [TOP]

  • Desplan C., Benicourt C., Jullienne A., Second N., Calmettes C., Moukhtar M.S., Milhaud G.
    Cell-free translation of mRNA coding for human and murine Calcitonin.
    FEBS Letters 117, 89-92 (1980).
  • Coevoet B., Desplan C., Sebert J.L., Makdassi R., Andrejak M., Gheerbrant J.D., Tolani M., Calmettes C., Moukhtar M.S., Fournier A.
    Effect of Propanolol and Metoprolol on Parathyroid hormone and Calcitonin secretions in uremic patients.
    British Med. J., 280, 1344-1346 (1980).
  • Anghileri L., Delbruck H., Cressent M., Desplan C., Talbot J.N., Milhaud G.
    Effects of Calcitonin on metastasis formation by experimental tumors.
    Archiv. Gesgbroal., 50, 105-111 (1980).

1979 [TOP]

  • Desplan C., Jullienne A., Moukhtar M.S., Rivaille P.,Raulais D., Boccart B., Milhaud G.
    Comparison of two N-terminal radioimmunoassays for the Parathyrin, Brewer and Niall sequences.
    Radioimmunology 1979, Bizollon C.A. ed., Elsevier Amsterdam, 179-185 (1979).
  • Coevoet B., Andrejak M., Desplan C., Calmettes C., Moukhtar M.S., Quichard J., Sebert J.L., Harichaux R., Fournier A.
    Acute effect of Propanolol and Metoprolol on plasma concentrations of PTH and Calcitonin in uremic patients.
    Essential Hypertension, Thurn R.H. ed., Y.B.M.P., 219-229 (1979).

1978 [TOP]

  • Desplan C., Jullienne A., Moukhtar M.S., Raulais D., Rivaille P., Milhaud G.
    Isolation of circulating immunoreactive human PTH. Comparison with a 1-34 N-terminal synthetic fragment.
    P.S.E.B.M., 157, 241-244 (1978).
  • Berthelot A., Desplan C., Pernot F., Gairard A.
    PTH and cAMP during mineralocorticoid hypertension in the rat.
    Horm. Met. Res., 10, 83-87 (1978).
  • Desplan C., Jullienne A., Raulais D., Rivaille P., Barlet J.P., Moukhtar M.S., Milhaud G.
    Dosage radioimmunologique du fragment biologiquement actif de la PTH humaine.
    "Radioimmunoassay", IAEA ed., Vienna, 2, 405-416 (1978).
  • Fournier A., Coevoet B., Fremont J., Gueris J., Caillens G., Desplan C., Calmettes C., MoukhtarM.S.
    Propanolol therapy for secondary hyperparathyroidism in uremic patients.
    Lancet ii, 50-51 (1978).
  • Milhaud G., Calmettes C., Jullienne A., Boccart B., Desplan C., Moukhtar M.S.
    Hormone Parathyroidienne biologiquement active et hypercalcemie.
    Sem. hop., 54, 489-495 (1978).

1977 [TOP]

  • Rivaille P., Jullienne A., Desplan C., Barlet J.P., Monet J.D., Bader C., Milhaud G.
    Synthesis in the fields of 1-34 human PTH fragments; their in vitro and in vivo bioactivity and Immunoreactivity.
    Medicinal Chemistry V, Elsevier Sc. pub., Amsterdam, 79-84 (1977).
  • Desplan C., Jullienne A., Moukhtar M.S., Milhaud G.
    Sensitive assay for biologically active fragment of human Parathyroid Hormone.
    Lancet ii, 198-199 (1977).