Research in our lab utilizes expertise in organic chemistry to develop synthetic inhibitors of protein-protein and protein-nucleic acids interactions. These interactions are difficult targets for typical small molecule ligands. We are using a rational design approach to prepare synthetic scaffolds that will potentially offer highly specific reagents for biological studies.
Proteins often utilize small folded domains for recognition of other biomolecules. The basic hypothesis guiding our research is that by mimicking these folded domains we can modulate the function of a particular protein with metabolically stable synthetic molecules. Our strategy for developing structured peptidic and nonpeptidic oligomers that display protein-like functionality is outlined on the Research page and in our publications.