Check out restaurants, and try to find your local grocery store (potraviny). Locate the nearest trams and subway stops!
Head down to Tesco (trams 22, 23 and many others stop at Narodni Trida) and pick up the toiletries you didn’t bring with you from the U.S. Everything you need can be found on the ground floor! Head downstairs for some cheap groceries, they even have some U.S. brands if you get brandsick, and want some Skippy.
This seems obvious, but for some reason people forget. Just do it.