Dihydroxy-carotenoid liposomes inhibit phototoxicity in Paramecium caudatum.

Rich MR; de Strulle R; Ferraro G; Brody SS

Department of Biology, New York University, NY 10003.

Photochem Photobiol 56: 413-6 (1992)

The phototoxic effects of hematoporphyrin derivative, using Paramecium caudatum as a model system, are significantly reduced in the presence of carotenoid-containing liposomes. Multilammelar large or small unilammelar vesicles, containing specific carotenoids, were effective in protecting the organism, whether administered exogenously in the bathing solution, or via incubation of paramecia in starved culture media containing carotenoid liposomes. The effectiveness of the carotenoids as inhibitors of phototoxic effects was found to depend on the mode of administration, with small unilammelar being more effective than multilammelar large vesicles for all carotenoids tested. Small unilammelar vesicles containing the dihydroxy-carotenoids zeaxanthin or astaxanthin afforded the greatest protection in both exogenous and endogenous studies. The results of this study suggest that carotenoid efficacy may be determined, in part, by the environment of the carotenoid molecules.

Mesh Headings

Comparative Study
Drug Carriers
Hematoporphyrin Derivative*
Radiation-Sensitizing Agents*
Structure-Activity Relationship

Unique Identifier: 93066750

Chemical Identifiers (Names)

(Drug Carriers)
(Radiation-Sensitizing Agents)
68335-15-9 (Hematoporphyrin Derivative)