Fluorescent Probes

for Divalent Metal Ions

We have constructed fluorescent chemosensors for metal ions, especially, Zn(II), Cu(II), and Mn(II). Besides the synthesis of interesting new probes, we have explored new spectroscopic methods of visualization, especially to quantify both the amount of probe and metal in the sample. Our main focus recently has been on cellular and tissue transport and distribution of Mn(II), which is important in neurobiology including calcium channel function and Manganese-Enhanced Magnetic Resonance Imaging (MEMRI).

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