Assembly of Organic Polymers

on a DNA Template

In collaboration with Ned Seeman's laboratory, we have studied the DNA-templated assembly of industrial-like polymers (e.g., nylon) with controlled size, sequence, and topology. Essential to this task is the preparation of ladder polymers in which single- and double-stranded DNA is covalently attached to a polyamide. In addition to applications in structural DNA nanotechnology, these materials may be of interest for biological applications such as targeting or antisense therapy.

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