Students should check the basic medical sciences class schedule (available in the basic medical sciences office) for up-to-date information on courses before registering.
Students should familiarize themselves with the separate calendars used by the School of Medicine and the Graduate School of Arts and Science since certain basic medical sciences courses begin before or after the opening of the regular term in the Graduate School of Arts and Science. Courses are offered at the School of Medicine unless otherwise indicated.
Two-Part Courses: A hyphen indicates a full-year course with credit granted only for completing both terms. A comma indicates credit is granted for completing one term.
The following courses are lectures unless otherwise indicated.
Advanced Biochemistry and Cell Biology G16.2001-2002 Prerequisites: basic biochemistry and cell biology. Lecture and conference. Weiss. 6 points per term.
Combines fundamental concepts of biochemistry and cell biology. Offered to first-year graduate and M.D.-Ph.D. students. This is an intensive advanced course.
Neuroscience G16.2009 Prerequisite: G16.2503. Lecture, laboratory, and conference. Llinas, Walton. 6 points
Introduction to neuroanatomy, neurobiology, behavioral and clinical neurology.
Cell Biology of Tissues and Organs G16.2013 Prerequisite: G16.2103 and G16.2104, or permission of the instructor. Lecture and laboratory. Sabatini. 4.5 points.
Provides an understanding of the structural and functional organization of the human body at the cellular and subcellular levels. Covers the histological organization of tissues and organs, supplemented with specific cellular and functional correlations and observations of clinical significance. Microscopic slides and electron micrographs are examined in laboratory. An extensive collection of 35-mm slides organized into discrete units covering the basic tissues and organ systems is provided.
Gross Anatomy G16.2014 Lecture and conference. Bogart. 6 points.
Special Topics in Cellular and Molecular Biology G16.2016-2017 Prerequisite: G16.2103. Cowin, Frey. 3 points per term.
A series of courses given by the cell biology faculty under the general title of special topics in cellular and molecular biology. Each semester one specialized subject is treated in detail. Subjects include regulation of gene expression in eukaryotes; control of cell division; biogenesis, structure, and function of subcellular organelles; various aspects of the molecular basis of disease.
Biological Chemistry G16.2103 Prerequisite: organic chemistry. Lecture and conference. D'Eustachio. 4.5 points.
Molecular and Cell Biology G16.2104 Prerequisite: G16.2103 or permission of the instructor. Lecture and laboratory. Kreibich. 4.5 points.
Given by the Departments of Cell Biology and Biochemistry as well as by invited speakers. Topics include DNA replication and transcription, gene structure and function, protein biosynthesis, biological membranes, subcellular organelles, and cytoskeletal elements. Laboratory includes ultrastructural techniques, cell culture, phagocytosis-endocytosis, immunocytochemistry and genetic diagnosis using the polymerase chain reaction.
Readings in Biochemistry and Molecular and Cell Biology G16.2110 Prerequisites: G16.2103 and G16.2104. Lecture and conference. Rush. 3 points.
Students taking the basic medical biochemistry and molecular and cell biology courses are exposed to original literature relating to these subjects. Assigned readings are discussed under a tutorial format that includes student presentations.
Microbiology G16.2202 Lecture, laboratory, and conference. Nachbar. 6 points.
The study of bacteria, viruses, and fungi as agents of infectious disease and as models for metabolic disease.
Human Genetics G16.2204 Thomas. 3 points.
Deals with the various aspects of genetics. Topics include genetics of hemoglobin abnormalities, blood groups, inborn errors of metabolism, immunogenetics, human cytogenetics, developmental genetics, population genetics, and genetic counseling.
Molecular Virology G16.2210 Prerequisites: biochemistry and microbiology (G16.2202 or equivalent). Lecture and conference. Carroll. 4 points.
Topics include classification of viruses, structure of virions, chemistry and physical chemistry of the virion and its components, assay of virus infectivity and other viral-specific properties, replication of RNA and DNA viruses, and host-cell response to virus infections.
Molecular Genetics G16.2213 4 points.
Formal transmission genetics in prokaryotes, fungi, dipterans and mammals, including a section on human genetics, is presented along with modern methods of genetic analysis (e.g., cloning, reverse genetics, RFLP analysis, etc.). The course consists of formal lectures and discussions of original research papers. Students are required to present a research paper during the course.
Molecular and Cellular Development G16.2214 Prerequisite: G16.2213. 6 points.
This course follows G16.2213 and presents differentiation in different life forms. Focus on mechanisms of developmental decision making and commitment at the molecular, cellular, and organismic level as well as study of systems in which genetic analysis (recombinational) is easily performed, i.e., those covered in G16.2213, but will also examine organisms that can only
be studied by reverse paragenetics. The course follows the same organization as G16.2213.
Introductory Immunology G16.2306 Zolla-Pazner. 3 points.
Covers the principles of modern immunochemistry and immunobiology. Selected applications of basic immunologic knowledge to human disease are included.
General Immunology G16.2308 Prerequisite: G167.2103 or the equivalent, cell biology, animal genetics, and vertebrate anatomy. Lecture and conference. Phillips-Quagliata. 6 points.
Immunochemistry, cellular immunology, and immunogenetics; structure and function of immunoglobulins and complement components; networks and idiotype regulation; cell cooperation; tolerance and suppression; immune response genes and the major histocompatibility complex; immunoglobulin genes; immunological mediators of inflammation; immunological diseases; tumor immunology.
General Pathology G16.2309 Prerequisite: G16.2013. Lecture, laboratory, and conference. Defendi. 6 points.
Introduction to experimental pathology; morphological manifestations of tissue damage, repair, regeneration, and neoplasia are interpreted in the light of concomitant biochemical and physiological alterations; study of gross and microscopic specimens; conferences on experimental pathology.
Molecular Oncology G16.2318 Prerequisite: G16.2103. Lecture. Pellicer, Teebor. 6 points.
Lecture series devoted to the molecular basis of cancer. Topics include somatic mutations and DNA repair mechanisms; viral systems relevant to cellular transformation and human cancer; the pathogenesis of cancer as a consequence of alterations in oncogenes; growth factor genes and tumor suppressor genes with emphasis on the function of their normal counterparts as well; tumor progression; mechanisms of metastasis and tumor immunology.
Environmental Carcinogenesis Identical to G48.2034. Prerequisites: biochemistry and histology, or permission of the instructor. Lecture and laboratory. Troll. 3 points.
Deals with chemical and physical agents that are carcinogens and a threat to both the general public and special populations. One group of agents, which metabolize to a proximal carcinogen and modify DNA, can be studied by mutagenesis. A second group, which increase mitosis and promote tumors at specific sites, may involve the depression of the genome.
Genetic Toxicology G16.2321 Identical to G48.2040. Prerequisite: biochemistry. Rossman. 3 points.
Analyzes how organisms handle damage to DNA by physical and chemical agents, the mechanisms of converting damage to mutations, and the theoretical basis for carcinogenesis screening methods utilizing mutagenesis. Topics: DNA repair pathways in prokaryotes and eukaryotes, error-free and error-prone repair, methods of measuring repair, enzymology of DNA repair, induction of prophage and systems for mutagenesis testing.
Principles in Pharmacology G16.2401 Stern. 1.5 points.
Basic principles in pharmacology including principles of drug action on receptors and autonomic pharmacology.
Pharmacology G16.2402 Prerequisites: G16.2103 and G16.2503. Lecture, laboratory, and conference. Altszuler, 6 points.
Molecular Pharmacology of Receptors and Signal Transduction G16.2404 Prerequisite: G16.2401. Stern. 3 points.
Molecular biology of receptors and signal transduction events with special emphasis on the growth factors.
Special Topics in Pharmacology G16.2406 Prerequisite: G16.2401. Stern. 1.5 points.
Current topics in pharmacology: adhesion molecules, signal transduction pathways, proteoglycans, antihistamines, anti-neoplastic drugs, and chemical carcinogenesis.
Free Radical Mechanisms in Biology G16.2411 Stern. 3 points.
Introduction to free radical chemistry with emphasis on the importance of free radicals in biological reactions.
Mammalian Physiology G16.2503 Prerequisites: vertebrate or human anatomy, biochemistry, and histology. Lecture, laboratory, and conference. Fisher, Llinas. 6 points.
Applies the principles of physics and chemistry to an understanding of the living animal. The physiology of the organ systems of humans is emphasized in preparation for understanding the diseased state. Emphasis is on critical thinking and a rational approach to problems in experimental biology. Major topics: cellular physiology, nerve and muscle, circulation, respiration, the kidneys, metabolism, endocrine glands, and gastrointestinal tract.
Neuronal Integration G16.2506 Prerequisite: G16.2009 or equivalent. Lecture. Llinas, Sugimori. 4.5 points.
Surveys the mechanisms of neuronal integration in the mammalian CNS. Provides students with an up-to-date understanding of how neurons process information. The course begins with neuronal morphology and a review of membrane properties. Neuronal integration is considered from an extracellular viewpoint, including the influence of the extracellular environment and field potentials generated by small ensembles of neurons. Considers the integrative properties of cells as studied using intracellular recording techniques.
Electrobiology of the Mammalian CNS G16.2507 Sugimori. 4.5 points.
Intrinsic and oscillatory properties of neurons in the mammalian central nervous system and the role these properties play in the function of the circuits in which they participate.
Synaptic Transmission G16.2511 Prerequisites: G16.2103 and G16.2503. Llinas, Walton. 3 points.
Lectures by staff and students on different aspects of synaptic transmission, physiology of the squid giant synapse, neuromuscular junction of the frog, and specific synapses of the central nervous system.
Seminar in Sensory Physiology G16.2513 Prerequisite: G16.2009 or equivalent. Gardner. 3 points.
Provides an in-depth examination of principles of sensory neurophysiology derived from readings of the original literature. Develops techniques for critical analysis of the sensory physiology and anatomy literature rather than presenting a comprehensive, detailed body of knowledge. Specific subjects include transduction mechanisms in sensory receptors, neuronal coding of sensory information, and central processing mechanisms.
Tutorials in Medical Sciences G16.2603-G16.2604 3 points per term.
Advanced instruction, for a limited number of students in a relatively limited topic, such as mechanisms of membrane excitation, structure and conformation of macromolecules, evolution of viruses, physical chemistry of proteins, physiology of the reticuloendothelial system, mechanisms of carcinogenesis, experimental hypersensitivity, homograft biology, blood coagulation, and electron microscopy. Note: Separate credit may be granted for tutorials in different subjects.
Parasitology I G16.2702 Lecture, laboratory, and conference. Nardin. 3 points.
Encompasses the course given to medical students, Parasitic Diseases, and includes additional laboratory and seminar hours for graduate students.
Parasitology II G16.2701 Prerequisite: G16.2702. Lecture, laboratory, and conference. Nardin. 3 points.
Molecular Evolution G16.2705 Enea. 3 points.
Phylogenetics, phylogeny and DNA hybridization, phylogeny and DNA sequence comparison, evolution of specific loci, evolution of multigene families, rates of molecular evolution, evolution of the genetic apparatus, genome evolution and acquisition of new functions, gene transfer in nature, selfish DNA versus selfish genomes, principles of molecular evolution.
Epidemiology G16.2706 1.5 points.
Encompasses the course given to second-year medical students and includes additional assigned work for graduate students.
Medical Statistics I, II G16.2707, 2708 Recommended proficiency in algebra. 3 points.
Explores the foundation of statistical reasoning and the data analysis techniques applicable to biomedical research. Topics: significance testing (parametric, nonparametric), analysis of variance and covariance, regression analysis, experimental designs, etc. Basic computer skills are developed. The second half of the course is suggested for those having taken the first half.
RESEARCH
Individual investigations may be undertaken in each department in the areas of research listed below and in related fields. The number of points for each course is at the discretion of the adviser.
Research in Anatomy G16.3001, 3002 Bogart. 1-12 points per term.
Research in Cell Biology G16.3007, 3008 Adesnik, Black, Cowin, Derman, Ehrlich, Freedberg, Frey, Joyner, Kreibich, Krey, Lang, Mohraz, Morimoto, Moscatelli, Orlow, Philips, Rifkin, Rindler, Ron, Ruiz i Altaba, Sabatini, Salzer, Sun, Wilson. 1-12 points per term.
Research in Environmental Oncology G16.3011, 3012 Bosland, Burns, Costa, Dubin, Flescher, Frenkel, Garte, Goldschmidt, Gordon, Klein, Penn, Petrenko, Rom, Rossman, Schlessinger, Shore, Snow, Solomon, Snyder, Solomon, Taioli, Toniolo, and Wirgin. 1-12 points per term.
Research in Biochemistry G16.3101, 3102 Abagayan, Blumenberg, Borowiecz, Cowan, Day, D'Eustachio, Godson, Hedge, Jelinek, Klein, Lee-Huang, Rush, Schneider, Thomas, Wolinsky, Ziff. 1-12 points per term.
Research in Microbiology G16.3201, 3202 Basilico, Drlica, Dubnau, Elsbach, Frendewey, Garabedian, Gennaro, Ho, Kim, Koup, Kramer, Kreiswirth, Le, Li, Maas, Mansukhani, Marx, Mindich, Moore, Novick, Parks, Pinter, Smith, Tanese, Vilcek, Weiss, Yip, Zychlinsky. 1-12 points per term.
Research in Pathology G16.3301, 3302 Basch, Boorstein, Buxbaum, Carroll, Defendi, Diment, Frangione, Giancotti, Gold, Inghirami, Ittman, Landau, Levy, Liu, Meruelo, Newcomb, Nussenzweig, Pellicer, Phillips-Quagliata, Teebor, Thorbecke, Vukmanovic, Weissman, Zolla-Pazner. 1-12 points per term.
Research in Pharmacology G16.3401, 3402 Altszuler, Devi, Grossman, Grumet, Lax, Levy, B. Margolis, R. Margolis, Musacchio, Raaka, Reem, Samuels, Sap, Schlessinger, Simon, Skolnik, Stanley, Stern, Sun. 1-12 points per term.
Research in Physiology and Neuroscience G16.3501, 3502 Baker, Blumfield, Cherksey, Chesler, Gardner, Goldstein, Hillman, Jacoby, Joyner, Kolodny, Llinas, Monaco, Nicholson, Rice, Reibman, Rosenbluth, Rubinson, Rudy, Ruiz i Altaba, Simpson, Sugimori, Walton, Welsh, Witkovsky, Young, Zadunaisky. 1-12 points per term.
Research in Parasitology G16.3701, 3702 Barnwell, Clarkson, Enea, Frevert, Galinski, Nardin, Pologe, Vanderberg, Zavala. 1-12 points per term.
SEMINARS
Seminar in Environmental Oncology G16.3013, 3014 Penn. 1.5 points per term.
Seminar in Biochemistry G16.3111, 3112 Borowiec. 1.5 points per term.
Seminar in Cell Biology G16.3115, 3116 Adesnik. 1.5 points per term.
Seminar in Microbiology G16.3211, 3212 Frendewey. 1.5 points per term.
Seminar in Pathology G16.3311, 3312 Carroll. 1.5 points per term.
Seminar in Pharmacology G16.3411, 3412 Stern. 1.5 points per term.
Seminar in Physiology and Neuroscience G16.3507, 3508 Walton. 1.5 points per term.
Seminar in Parasitology G16.3711, 3712 Pologe. 1.5 points per term.
GSAS /
NYU
-- last modified 25 June 1996