Racquel Z . LeGeros, PhD

Professor and Associate Chair, Department of Biomaterials and Biomimetics
Leonard I. Linkow Professor of Implant Dentistry
Director, Calcium Phosphate Research Laboratory

Email: rzl1@nyu.edu

BS 1954 (Chemistry) Adamson University, Manila, Philippines; MS 1957 (Organic Chemistry) New York University; PhD 1967 (Biochemistry) New York University; Doctorat Honoris Causa (honorary doctorate) 2006 Université de Nantes

Research Interests: Effect of carbonate, fluoride, magnesium, zinc  pyrophosphate, citrate, and other elements on the formation and stability of biologic and synthetic apatites and related calcium phosphates • Preparation and/or characterization of calcium phosphate–based biomaterials (bioceramics, cements, glasses, composites) for bone substitution, repair, and osteoporosis therapy • Implant surface modifications and coatings

Representative publications

Yamada Y, Ito A, Kohjima H, Sakane M, Miyaka S, Uemura T, LeGeros RZ (2008). Inhibitory effect of Zn2+ in zinc-containing beta-tricalcium phosphate on resorbing activity of mature osteoclasts. J Biomed Mater Res 84A:344-352.

Wakae H, Takeuchji A, Udoh K, Matsuya S, Munar M, LeGeros RZ, Nakagawa M, Nakashima A, Ishikawa K (2008). Fabrication of cancellous bone type carbonate apatite foam by hydrothermal conversion of alpha-tricalcium phosphate in carbonate solutions. J Biomed Mater Res 87A:957-963.

Otsuka M, Oshinbe A, LeGeros RZ, Tokudome Y, Ito A, Otsuka K, Higuchi WI (2008). Efficacy of a new injectable calcium phosphate ceramic suspension on improving bone properties of ovariectomized rats. J Pharm Sci 421-432.

LeGeros RZ, Mijares D, Yao F, Tannous S, Catig G, Xi Q, Dias R, LeGeros JP (2008). Synthetic bone mineral (SBM) for osteoporosis therapy: Part I. Prevention of bone loss from mineral deficiency. Key Engineer Mater 361-363:43-46.

Chuo AHK, LeGeros RZ, Mijares D. Frondoza C, LeGeros JP (2008). Calcium phosphate mineralized GBR membranes: Preparation and properties. Key Engineer Mater 361-363:435-438.

Daculsi G, LeGeros RZ, Grimaldi G, Aguado E, LeGeros J (2008). Effect of sintering process on microporosity and bone ingrowth on biphasic calcium phosphate ceramics. Key Engineer Mater 361-363:1139-1142.

Namata Y, Nakada H, Sakae T, Kimura-Suda H, LeGeros RZ, Kobayashi K, Makimura M (2008). Qualitative study of the new bone formation surrounding the Ti implant by FT-IR and polarizing microscope. J hard Tiss Biol 17:131-140.

Nakada H, Numata Y, Sakae T, Oazaki Y, Tanimoto Y, Ookubo A, Kobayashi K, LeGeros RZ (2008). Comparison of bone mineral density and area of newly formed bone around Ti-15%Zr-4%Nb-4%Ta alloy and Ti-6%Al-4%V alloy implants. J Hard Tiss Biol 17:99-108

Chou AHK, LeGeros RZ, Chen Z, Li Y (2007). Antibacterial effect of zinc phosphate mineralized guided bone regneration membranes. Implant Dent 16:89-100.

Sogo Y, Ito A, Yokohama D, LeGeros RZ (2007). Synthesis of fluoride-releasing carbonate apatites for bone substitutes. J Mater Sci Mater Med 18:1001-1007.

Nakada H, Sakae T, LeGeros RZ, LeGeros JP (2007). Early tissue response to modified implant surfaces using back-scattered imaging. Implant Dent 16:281-285.

Ito A, Senda K, Sogo Y, Oyane A, LeGeros RZ (2006). Dissolution of zinc-containing tricalcium phosphate ceramics. Biomed Mater 1:134-138.

LeGeros RZ, LeGeros JP (2006). In situ characterization of the degradation behavior of plasma-sprayed boatings on orthopedic and dental implants. Adv Sci Tech 49:203-211.

Texeira CC, Karkia C, LeGeros RZ (2006). Biphasic calcium phosphate: a scaffold for growth plate chondrocyte maturation. Tissue Engineer 12:2283-2289.

Rohanizadeh R, LeGeros RZ, Harsono M, Benavid A (2005). Adherent apatite coating on titanium substrate using chemical deposition. J Biomed Mater Res 72A:428-438.

Kothpalli C, Wei M, LeGeros RZ, Shaw MT (2005). Influence of temperature and aging time on HA synthesized by the hydrothermal method. J Mat Sci Mat Med 16:441-446.


Books & book chapters

LeGeros RZ (2008). Calcium-phosphate based osteoinductive materials. Chem. Revs 108:4742-4753.

LeGeros RZ, LeGeros JP (2008). Hydroxyapatite. In: Handbook of Bioceramics and their Applications. Kokubo T (ed). Woodhead Publishing Ltd: London, pp. 367-394.

LeGeros RZ, Daculsi G, LeGeros JP (2008) Bioactive Bioceramics. In: Orthopedic Biology and Medicine: Musculoskeletal Tissue Regeneration: Biological Materials and Methods” Chapter 8. Pietrzak WS (Ed). Humana Press Inc, New Jersey, pp. 153-181.

Daculsi G, LeGeros RZ (2008). Tricalciumphosphate/Hydroxyapatite Biphasic Calcium Phosphates. In: Handbook of Biceramics and their Applications. Kokubo T (ed). Woodhead Publishing Ltd: London. Pp. 395-423.

Ito A, LeGeros RZ (2008). Magnesium- and Zinc-substituted beta-Tricalcium Phosphate Materials. In: Progress in Bioceramics. Vallet-Regi M (ed). Key Engineer Mater 377:85-98. Trans Tech Publications, Zurich.

Lee-Y-K, LeGeros RZ (2008). Calcium Phosphate Glass. In: Progress in Bioceramics. Vallet-Regi M (ed). Key Engineer Mater 377:43-72. Trans Tech Publications, Zurich.

Enkel B, Dupas C, Armengol V, Adou JA, Bosco J, Daculsi G, Alain J, LeGeros RZ, Weiss P (2008). Bioactive materials in endodontics. Expert Rev Med Devices 5:475-494.

LeGeros RZ (1991). Calcium Phosphates in Oral Biology and Medicine. Monographs in Oral Sciences. Vol 15 Myers H (ed). Basel: Karger.