Nate Traaseth Lab


Publications with NYU Affiliation

49. Traaseth NJ, Banigan JR, Leninger M (2015) Exploring Transporters within the Small Multidrug Resistance Family Using Solid-State NMR Spectroscopy. eMagRes, 4, 551-9. [pdf] [link to eMagRes]

48. Banigan JR, Gayen A, Cho MK, Traaseth NJ (2015) A Structured Loop Modulates Coupling Between the Substrate-Binding and Dimerization Domains in the Multidrug Resistance Transporter EmrE. J Biol Chem, 290, 805-14. [pdf]

47. Banigan JR, Gayen A, Traaseth NJ (2015) Correlating Lipid Bilayer Fluidity with Sensitivity and Resolution of Polytopic Membrane Protein Spectra by Solid-State NMR Spectroscopy. Biochim Biophys Acta, 1848, 334-41. [pdf]

46. Cho MK+, Gayen A+, Banigan JR, Leninger M, Traaseth NJ (2014) The Intrinsic Conformational Plasticity of Native EmrE Provides a Pathway for Multidrug Resistance. J Am Chem Soc, 136, 8072-80. (+equal contribution) [pdf]

45. Kushal S, Lao BB, Henchey LK, Dubey R, Mesallati H, Traaseth NJ, Olenyuk BZ, Arora PS (2013) Protein Domain Mimetics as in vivo Modulators of Hypoxia-Inducible Factor Signaling. Proc Natl Acad Sci, 110, 15602-7. [pdf]

44. Gayen A, Banigan JR, Traaseth NJ (2013) Ligand-Induced Conformational Changes of the Multidrug Resistance Transporter EmrE Probed by Oriented Solid-State NMR Spectroscopy. Angew Chemie Int Ed, 52, 10321-4. [pdf]

*Featured on back-cover [link].

43. Chen H, Huang Z, Dutta K, Blais S, Neubert TA, Li X, Cowburn D, Traaseth NJ, Mohammadi M (2013) Cracking the Molecular Origin of Intrinsic Tyrosine Kinase Activity through Pathogenic Gain-of-Function Mutations. Cell Reports, 4(2), 376-84.[pdf].

*F1000 Article Recommendation [link].

42. Banigan JR, Gayen A, Traaseth NJ (2013) Combination of 15N Reverse Labeling and Afterglow Spectroscopy for Assigning Membrane Protein Spectra by Magic-Angle-Spinning Solid-State NMR: Application to the Multidrug Resistance Protein EmrE. J Biomolec NMR, 55, 391-9.[pdf]

41. Banigan JR and Traaseth NJ (2012) Using Afterglow Magnetization from Cross-Polarization Magic-Angle-Spinning Solid-State NMR Spectroscopy to Obtain Simultaneous Heteronuclear Multidimensional Spectra. J Phys Chem B, 116, 7138-44.[pdf]

40. Traaseth NJ, Chao F.A., Masterson LR, Mangia S, Garwood M, Michaeli S, Seelig B, Veglia G (2012) Heteronuclear Adiabatic Relaxation Dispersion (HARD) for Quantitative Analysis of Conformational Dynamics in Proteins. J Magn Reson, 219, 75-82. [pdf]

39. Verardi R, Traaseth NJ, Masterson LR, Vostrikov VV, Veglia G. (2012) Isotope Labeling for Solution and Solid-state NMR Spectroscopy of Membrane Proteins. Adv Exp Med Biol, 992, 35-62. [pdf]


Publications from research prior to joining NYU

38. Gustavsson M, Verardi R, Mullen DG, Mote KR, Traaseth NJ, Gopinath T, Veglia G (2013) Allosteric Regulation of SERCA by Phosphorylation-Mediated Conformational Shift of Phospholamban. Proc Natl Acad Sci, 110, 17338-43. [pdf]

37. Veglia G, Traaseth NJ, Shi L, Verardi R, Gopinath T, Gustavsson M (2012) The Hybrid Solution/Solid-State NMR Method for Membrane Protein Structure Determination. Comprehensive Biophysics, 1, 182-198. [pdf]

36. Gustavsson M, Traaseth NJ, Veglia G (2012) Probing Ground and Excited States of Phospholamban in Model and Native Lipid Membranes by Magic Angle Spinning NMR. Biochim Biophys Acta, 1818, 146-53. [pdf]

35. Gustavsson M, Traaseth NJ, Veglia G (2011) Activating and Deactivating Roles of Lipid Bilayers on the Ca2+-ATPase/Phospholamban Complex. Biochemistry, 50, 10367-74. [pdf]

34. Mote KR, Gopinath T, Traaseth NJ, Veglia G (2011) Multidimensional Oriented Solid-State NMR Experiments Enable the Sequential Assignment of Uniformly 15N Labeled Integral Membrane Proteins in Magnetically Aligned Lipid Bilayers. J Biomol NMR, 51, 339-46. [pdf]

33. Gaffarogullari EC, Masterson LR, Metcalfe EE, Traaseth NJ, Balatri E, Musa MM, Mullen D, Distefano MD, Veglia G (2011) A Myristoyl/Phosphoserine Switch Controls camp-Dependent Protein Kinase Association to Membranes. J Mol Biol, 411, 823-36. [pdf]

32. Verardi R, Shi L, Traaseth NJ, Walsh N, Veglia G (2011) Structural Topology of Phospholamban Pentamer in Lipid Bilayers by a Hybrid Solution and Solid-State NMR Method. Proc Natl Acad Sci, 108, 9101-6. [pdf]

31. Traaseth NJ, Veglia G (2011) Frequency-Selective Heteronuclear Dephasing and Selective Carbonyl Labeling to Deconvolute Crowded Spectra of Membrane Proteins by Magic Angle Spinning NMR. J Magn Reson, 211, 18-24. [pdf]

30. Gustavsson M, Traaseth NJ, Karim CB, Lockamy EL, Thomas DD, Veglia G (2011) Lipid-Mediated Folding/Unfolding of Phospholamban as a Regulatory Mechanism for the Sarcoplasmic Reticulum Ca(2+)-ATPase. J Mol Biol, 408, 755-65. [pdf]

29. Shi L, Traaseth NJ, Verardi R, Gustavsson M, Gao J, Veglia G (2011) Paramagnetic-based NMR Restraints Lift Residual Dipolar Coupling Degeneracy in Multidomain Detergent-Solubilized Membrane Proteins. J Am Chem Soc, 133, 2232-41. [pdf]

28. Verardi R, Traaseth NJ, Shi L, Porcelli F, Monfregola L, De Luca S, Amodeo P, Veglia G, Scaloni A. (2011) Probing membrane topology of the antimicrobial peptide distinctin by solid-state NMR spectroscopy in zwitterionic and charged lipid bilayers. Biochim Biophys Acta, 1808, 34-40. [pdf]

27. Traaseth NJ, Gopinath T, Veglia G (2010) On the Performance of Spin Diffusion Techniques in Oriented Solids: Prospects for Resonance Assignments and Distance Measurements from Separated Local Field Experiments. J Phys Chem B, 114, 13872-80. [pdf]

26. Veglia G, Ha KN, Shi L, Verardi R, Traaseth NJ (2010) What can we learn from a small regulatory membrane protein? Methods Mol Biol 654, 303-19. [pdf]

25. Mangia S*, Traaseth NJ*, Veglia G, Garwood M, Michaeli S. (2010) Probing slow protein dynamics by adiabatic R(1rho) and R(2rho) NMR experiments. J Am Chem Soc 132, 9979-81. [pdf] (*co-first author*)

24. Gopinath T, Verardi R, Traaseth NJ, Veglia G (2010) Sensitivity enhancement of separated local field experiments: application to membrane proteins. J Phys Chem B 114, 5089-95. [pdf]

23. Gopinath T, Traaseth NJ, Mote K, Veglia G. (2010) Sensitivity enhanced heteronuclear correlation spectroscopy in multidimensional solid-state NMR of oriented systems via chemical shift coherences. J Am Chem Soc 132, 5357-63. [pdf]

22. Haynes V, Traaseth NJ, Elfering S, Fujisawa Y, Giulivi C. (2010) Nitration of specific tyrosines in FoF1 ATP synthase and activity loss in aging. Am J Physiol Endocrinol Metab 298, E978-87. [pdf]

21. Traaseth NJ, Veglia G (2010) Probing excited states and activation energy for the integral membrane protein phospholamban by NMR CPMG relaxation dispersion experiments. Biochim Biophys Acta 1798, 77-81. [pdf]

20. Shi L, Traaseth NJ, Verardi R, Cembran A, Gao J, Veglia G. (2009) A refinement protocol to determine structure, topology, and depth of insertion of membrane proteins using hybrid solution and solid-state NMR restraints. J Biomol NMR 44, 195-205. [pdf]

19. Traaseth NJ, Shi L, Verardi R, Mullen DG, Barany G, Veglia G. (2009) Structure and topology of monomeric phospholamban in lipid membranes determined by a hybrid solution and solid-state NMR approach. Proc Natl Acad Sci 106, 10165-70. [pdf]

18. Deng Y, Wang Y, Holtz B, Li J, Traaseth N, Veglia G, Stottrup BJ, Elde R, Pei D, Guo A, Zhu XY (2008) Fluidic and air-stable supported lipid bilayer and cell-mimicking microarrays. J Am Chem Soc 130, 6267-71. [pdf]

17. Traaseth NJ, Verardi R, Veglia G (2008) Asymmetric methyl group labeling as a probe of membrane protein homo-oligomers by NMR spectroscopy. J Am Chem Soc 130, 2400-1. [pdf]

16. Masterson LR, Mascioni A, Traaseth NJ, Taylor SS, Veglia G (2008) Allosteric cooperativity in protein kinase A. Proc Natl Acad Sci 105, 506-11. [pdf]

15. Traaseth NJ, Ha KN, Verardi R, Shi L, Buffy JJ, Masterson LR, Veglia G (2008) Structural and dynamic basis of phospholamban and sarcolipin inhibition of Ca(2+)-ATPase. Biochemistry 47, 3-13. [pdf]

14. Ha KN, Traaseth NJ, Verardi R, Zamoon J, Cembran A, Karim CB, Thomas DD, Veglia G (2007) Controlling the inhibition of the sarcoplasmic Ca2+-ATPase by tuning phospholamban structural dynamics. J Biol Chem 282, 37205-14. [pdf]

13. Traaseth NJ, Verardi R, Torgersen KD, Karim CB, Thomas DD, Veglia G (2007) Spectroscopic validation of the pentameric structure of phospholamban. Proc Natl Acad Sci 104, 14676-81. [pdf]

12. Gor'kov PL, Chekmenev EY, Li C, Cotten M, Buffy JJ, Traaseth NJ, Veglia G, Brey WW (2007) Using low-E resonators to reduce RF heating in biological samples for static solid-state NMR up to 900 MHz. J Magn Reson 185, 77-93. [pdf]

11. Traaseth NJ, Buffy JJ, Zamoon J, Veglia G (2006) Structural dynamics and topology of phospholamban in oriented lipid bilayers using multidimensional solid-state NMR. Biochemistry 45, 13827-34. [pdf]

10. Buffy JJ, Traaseth NJ, Mascioni A, Gor'kov PL, Chekmenev EY, Brey WW, Veglia G (2006) Two-dimensional solid-state NMR reveals two topologies of sarcolipin in oriented lipid bilayers. Biochemistry 45, 10939-46 [pdf]

9. Traaseth NJ, Thomas DD, Veglia G (2006) Effects of Ser16 phosphorylation on the allosteric transitions of phospholamban/Ca(2+)-ATPase complex. J Mol Biol 358, 1041-50. [pdf]

8. Buffy JJ, Buck-Koehntop BA, Porcelli F, Traaseth NJ, Thomas DD, Veglia G (2006) Defining the intramembrane binding mechanism of sarcolipin to calcium ATPase using solution NMR spectroscopy. J Mol Biol 358, 420-9. [pdf]

7. Metcalfe EE, Traaseth NJ, Veglia G (2006) Serine 16 Phosphorylation Induces an Order-to-Disorder Transition in Monomeric Phospholamban. Biochemistry 44, 4386-96. [pdf]

6. Haynes V, Elfering S, Traaseth N, Giulivi C (2004) Mitochondrial nitric-oxide synthase: enzyme expression, characterization, and regulation. J Bioenerg Biomembr 36, 341-6. [pdf]

5. Traaseth N, Elfering S, Solien J, Haynes V, Giulivi C (2004) Role of calcium signaling in the activation of mitochondrial nitric oxide synthase and citric acid cycle. Biochim Biophys Acta 1658, 64-71. [pdf]

4. Elfering SL, Haynes VL, Traaseth NJ, Ettl A, Giulivi C (2004) Aspects, mechanism, and biological relevance of mitochondrial protein nitration sustained by mitochondrial nitric oxide synthase. Am J Physiol Heart Circ Physiol 286, H22-9. [pdf]

3. Haynes V, Elfering SL, Squires RJ, Traaseth N, Solien J, Ettl A, Giulivi C (2003) Mitochondrial nitric-oxide synthase: role in pathophysiology. IUBMB Life 55, 599-603. [pdf]

2. Giulivi C, Traaseth NJ, Davies KJ (2003) Tyrosine oxidation products: analysis and biological relevance. Amino Acids 25, 227-32. [pdf]

1. Steffen M, Sarkela TM, Gybina AA, Steele TW, Traaseth NJ, Kuehl D, Giulivi C (2001) Metabolism of S-nitrosoglutathione in intact mitochondria. Biochem J 356, 395-402. [pdf]