Welcome to the Mahal Lab
Located in the new Biomedical Chemistry Institute, in the Department of Chemistry at New York University, the Mahal Laboratory specializes in developing and utilizing cutting edge chemical and systems biology tools to understand the glycosylation in human health and disease.
MicroRNAs, small non-coding RNAs, control mRNA degradation and translation. Recent work by the Mahal Lab has shown that these RNAs are a major regulator of glycosylation. They control the human glycome and provide a critical link between the genome and glycan expression. Our work begins to map glycogenes into regulatory networks controlling cell phenotype, providing a means to deconstruct the information encoded in cell surface sugars. Check out our recent papers in PNAS (Agrawal et al., 2014) and Biochem. Biophys. Res. Commun. (Kaspar et al., 2014).
Lectin microarrays, the signature technology of our laboratory, enables rapid assessment of the glycome. Recently we have used this technology to show glycosylation translates cell specific information from the genome to the glycome (PNAS, 2014) and to establish esophagael cancer markers (Nature Medicine 2012). For a review of our work see Ribeiro et al, Curr. Opin. Chem. Biol., 2013.
CONGRATULATIONS to Linlin Wang on the acceptance of her glycan array comparison paper to Glycobiology (Wang et al., 2014, in press).
CONGRATULATIONS to Dr. Praveen Agrawal, Tomasz Kurcon, Dr. Kanoelani Pilobello, Dr. John Rakus and other members of the laboratory on the acceptance of our paper in miRNA regulation of glycans into PNAS (Agrawal et al, 2014, in press)
CONGRATULATIONS to Brian Kaspar and Sujeethraj Koppolu on the acceptance of their paper on the bioinformatic map of mIRNA regulation of human glycan pathways (Kaspar et al, 2014, in press).