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Research in Focus
NYU Dental Researchers Find Evidence of Periodontal Disease Leading to Gestational Diabetes
 


Dr. Ananda P. Dasanayake is a Professor of Epidemiology & Health Promotion at NYUCD.




A study by an NYU dental research team has found evidence that pregnant women with periodontal (gum) disease are more likely to develop gestational diabetes mellitus than pregnant women with healthy gums, a finding that underscores how important it is for expectant mothers to maintain good oral health.

The study, led by Dr. Ananda P. Dasanayake, Professor of Epidemiology & Health Promotion, followed 256 women at New York’s Bellevue Hospital Center through their first six months of pregnancy. Twenty-two women developed gestational diabetes. Those women had significantly higher levels of periodontal bacteria and inflammation than the other women in the study. The findings were published in the April 2008 issue of the Journal of Dental Research.

Gestational diabetes is characterized by an inability to transport glucose -- the main source of fuel for the body -- to the cells during pregnancy. The condition usually disappears when the pregnancy ends, but women who have had gestational diabetes are at a greater risk of developing the most common form of diabetes, known as Type 2 diabetes, later in life. Hispanics, Asians, and Native Americans are at the highest risk for developing gestational diabetes. Eighty percent of the women in the NYU study were Hispanic.

Inflammation associated with periodontal disease is believed to play a role in the onset of gestational diabetes, perhaps by interfering with the normal functioning of insulin, the hormone that regulates glucose metabolism.

“In addition to its potential role in preterm delivery, evidence that gum disease may also contribute to gestational diabetes suggests that women should see a dentist if they plan to get pregnant, and after becoming pregnant,” says Dr. Dasanayake. “Treating gum disease during pregnancy has been shown to be safe and effective in improving women’s oral health and minimizing potential risks.”

“In the future,” he added, “we can expect to see more research on the link between these two conditions involving other high-risk groups, such as Asian and Native American women.”

Dr. Dasanayake’s coinvestigators included Ms. Nok Chhun, a junior research scientist in the NYU Department of Epidemiology & Health Promotion; Dr. Ronald G. Craig, an Associate Professor of Basic Science and Craniofacial Biology and of Periodontology and Implant Dentistry; Ms. Amy Moore, a data manager and programmer in the Department of Epidemiology & Health Promotion; and Dr. Robert G. Norman, a statistician and Research Associate Professor of Epidemiology & Health Promotion, all of the NYU College of Dentistry. Coinvestigators also included Dr. Anne Tanner, a senior scientist in the Department of Molecular Genetics at The Forsyth Institute; and Dr. M. J. Lee, an Associate Professor and an OB-GYN in the Department of Obstetrics, Gynecology & Reproductive Sciences at Mount Sinai School of Medicine. The study was supported by a grant from the National Institute of Dental and Craniofacial Research (NIDCR).