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Bone Replacement

NICOLA C. PARTRIDGE, PhD
Professor and Chair, Department of Basic Science and Craniofacial Biology

EXPERTISE:
The role of parathyroid hormone in bone and mineralized research; electromagnetic pulse fields that stimulate bone, which can lead to new therapies for treating fractures that don’t heal and to improvements in orthopedics.

PROFESSIONAL BACKGROUND:
A national and international authority in the area of cell biology and an expert in bone and mineral research. Prior to joining the NYU College of Dentistry, she had served since 2000 as Professor and Chair of the Department of Physiology and Biophysics at the University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, where she also held an appointment as a Professor of Orthopedic Surgery.

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PUBLICATION HIGHLIGHTS:
“Premature Induction of Glucokinase in the Neonatal Rat by Thyroid Hormone.” European Journal of Biochemistry (1975).

“Factors Regulating the Appearance of Glucokinase in Neonatal Rat Liver.” Archives of Biology and Medicine (1978).

“Activity Ratio Measurements Reflect Intra-cellular Activation of Cyclic AMP-dependent Protein Kinase in Osteoblasts.” Endocrinology (1982).

“Regulation of Prostaglandin Production by Osteoblast-rich Calvarial Cells.” Prostaglandins (1985)

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“Immunohistochemistry of Collagenase in Calvariae of Rats Flown on Cosmos-2044.” NASA Technical Memorandum 108802 (1994)

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“N. Mitogen Activated Protein Kinase-dependent Inhibition of Osteocalcin Gene Expression by Transforming Growth Facto ß1.” Journal of Cellular Biochemistry (2009).


JOHN L. RICCI, PhD
Associate Professor of Biomaterials and Biomimetics

EXPERTISE:
Tissue-engineered bone replacement; tissue-engineered dental implants.

PROFESSIONAL BACKGROUND:
Recipient, NYU College of Dentistry’s Dean’s Faculty Research Award: Use of Enamel Matrix Proteins to Induce a Cementum Seal After Endodontic Therapy. A bioengineering expert, Dr. Ricci has published and lectured widely on modifying and texturing implant surfaces to increase their adhesion to bone tissue; current research focuses on mechanisms to substantially reduce bone regeneration time in the oral cavity and elsewhere in the body

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PUBLICATION HIGHLIGHTS:
“The Effects of Laser Microtextured Collars Upon Crestal Bone Levels of Dental Implants.”Implant Dentistry (2008)

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“Connective-Tissue Responses to Defined Biomaterial Surfaces.” Journal of Biomedical Materials Research (2008).

“In Vitro Characterization of a Calcium Sulfate/PLLA Composite for Use as a Bone Graft Material.” Journal of Biomedical Materials Research Part B: Applied Biomaterials (2007)

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SEIICHI YAMANO, DDS, PhD, DMD, MMSc
Assistant Professor of Prosthodontics

EXPERTISE:
Bone tissue engineering using gene therapy, an approach that may find utility as a more predictable and affordable treatment for bone regeneration in a variety of clinical settings

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PROFESSIONAL BACKGROUND:
As a research fellow at the NIH, focused on gene therapeutics for oral diseases, including Sjögren’s syndrome, especially possible involvement of unknown retroviruses; at the NIH, also involved with projects in tissue regeneration of salivary glands

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PUBLICATION HIGHLIGHTS:
“Enhanced Transduction of Mouse Salivary Glands with AAV5-based Vectors.” Gene Therapy (2006)

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“Role of VEGF in Small Bowel Adaptation After Resection: The Adaptive Response Is Angiogenesis Dependent.” American Journal of Physiology (2007)

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“Effects of Nicotine on Gene Expression and Osseointegration in Rats.” Clinical Oral Implants Research (2010)

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