1992 D.D.S., University of Porto, Portugal
1997 M.S., University of Pennsylvania
1997 Certificate in Orthodontics, University of Pennsylvania
2001 D.M.D., University of Pennsylvania
2001 Ph.D., University of Pennsylvania

My current research interests can be divided into 3 major areas: endochondral bone formation, tissue engineering, and orthodontics. My first area of interest is to elucidate the function of NO and cGMP pathways in endochondral bone formation and growth. A detailed study of the cGMP dependent Kinase II (cGK) knockout mouse, which presents severe dwarfism, will be carried out. Taking advantage of embryonic manipulation techniques (in ovo), mouse tibia organ cultures, and cell culture models, we will gain information on how overexpression or downregulation of components of the NO/cGMP pathways affect endochondral bone formation. In collaboration with the University of Porto, Portugal, knowledge acquired from studies of physiology of growth plate cartilate is being used as a platform for a totally new approach to tissue engineering of bone. We have successfully induced endochondral bone formation in vivo from a cartilage template created in vitro. Studies currently underway in my laboratory show that bone generated by this pathway is undistinghishable from the host bone and has the potential to grow.

M Hatori, K Klatte, C C Teixeira, and I M Shapiro, End Labeling Studies of fragmented DNA in the Avian Growth Plate: Evidence of Apoptosis in Terminally Differentiated Chondrocytes, J Bone and Mineral Research (1995) Vol10, 12:1960-1968.

M Hatori, C C Teixeira, K Debolt, M Pacifici, and I M Shapiro, Adenine Nucleotide Metabolism by Chondrocytes In Vitro: Role of ATP In Chondrocyte Maturation and Matrix Mineralization, J Cellular Physiology (1995) 165:468-479.

R Rajpurohit, C J Koch, Z Tao, C C Teixeira, and I M Shapiro, Adaptation of Chondrocytes to Low Oxygen Tension: Relationship Between Hypoxia and Cellular Metabolism, J of Cellular Physiology (1996) 168:424-432.

C C Teixeira, I M Shapiro, M Hatori, R Rajpurohit and C J Koch, Retinoic Acid Modulation of Glutathione and Cysteine Metabolism in Chondrocytes, Biochem J (1996) 314:21-26.

C C Teixeira, I M Shapiro, M Hatori, R Rajpurohit and C J Koch, Retinoic Acid Modulation of Glutathione and Cysteine Metabolism in Chondrocytes, Biochem J (1996) 314:21-26.

C C Teixeira, New horizons in understanding early tooth development, Clinical Orthodontics and Research, (1999) 2:171-174

K Mansfield, C C Teixeira, C Adams and I M Shapiro, Phosphate Ions Mediate Chondrocyte Apoptosis Through a Plasma Membrane Transporter Mechanism, Bone (2001) 28 (1): 1-8

C C Teixeira, K Mansfield, C Hertkorn, HIschiropoulos, I M. Shapiro, Pi-induced Chondrocyte Apoptosis is Linked to Nitric Oxide Generation, American J of Physiology (2001) 281: C833-C839