New York University Skip to Content Skip to Search Skip to Navigation Skip to Sub Navigation

Protein Molecule May Offer Method for Treating Untreatable Cancers

January 21, 2014

The effective treatment of cancer requires the ability to destroy cancerous cells. Nearly one-third of all cancers today involve mutations of the Kras gene, which has proven resistant to existing cancer treatments. The current prognosis for patients with mutant Kras cancers is poor because there is no effective treatment. However, recent analysis by Valerie Wells of NYU London and Livio Mallucci of King’s College London may present a new method to combat these untreatable cancers.


In a feature article in Drug Discovery Today, Wells and Mallucci discuss the current therapeutic strategies and their limitations, highlighting a new way forward using the recombinant form of a physiological protein molecule, beta-GBP, which has proven to be effective against human Kras-driven tumors in animal models.


There are several significant aspects to their discovery. First, the beta-GBP molecule they have identified kills mutant Kras and other cancer cells by activating alternative routes to destroy cancer while leaving normal cells unharmed. Second, the beta-GBP molecule is naturally occurring in the body and therefore would avoid the complexity of current combinatorial therapies and the issues of drug resistance, toxicity and all side effects experienced with chemotherapy. Finally, translation of beta-GBP to the clinic, facilitated by its physiological nature, could open a new therapeutic opportunity representing a significant step forward in the treatment of cancers resistant to all current methods.

Read the article in ScieneDirect.

This Article is in the following Topics:
Research

Type: Article

Protein Molecule May Offer Method for Treating Untreatable Cancers

Search News



NYU In the News

Entrepreneurship Lab Opens at NYU

Crain’s New York Business covered the opening of the Mark and Debra Leslie Entrepreneurial eLab, which will be the headquarters for NYU’s Entrepreneurial Institute and all of the University’s programs aimed at promoting innovation and startups.

A Globalizer for N.Y.U. in Abu Dhabi

The New York Times profiled Bill Bragin who will become the first executive artistic director of NYU Abu Dhabi’s new performing arts center.

Think Tank to Ponder a Future for Ballet

The New York Times profiled Jennifer Homans, the director of NYU’s new Center for Ballet and the Arts.

The Brilliant Ten: Jonathan Viventi Builds Devices That Decode Thoughts

Popular Science named Assistant Bioengineering Professor Jonathan Viventi as one of its “brilliant ten” for his research into brain implants that could one day halt epileptic episodes:

Living and Leaving the Dream: Adrian Cardenas’ Journey from the Major Leagues to College

The New York Times ran a feature on Adrian Cardenas, a former major league baseball player who is now studying philosophy and creating writing at NYU.

NYU Footer