New York University Skip to Content Skip to Search Skip to Navigation Skip to Sub Navigation

Neuroscientists Find Protein Linked to Cognitive Deficits in Angelman Syndrome

September 17, 2013

By James Devitt


Ateam of NYU neuroscientists has identified a protein in laboratory mice linked to impairments similar to those that characterize Angelman syndrome (AS)—a human condition associated with symptoms that include autism, intellectual disability, and motor abnormalities.
The findings appeared in the journal Cell Reports.


“By isolating a protein that contributes to cognitive deficits in Angelman syndrome, these findings mark a step forward in not only addressing AS, but perhaps other developmental disorders as well,” says Eric Klann, a professor in NYU’s Center for Neural Science and one of the study’s co-authors.


The study’s co-authors also included Hanoch Kaphzan, Akila Ramaraj, and Emanuela Santini of NYU’s Center for Neural Science as well as researchers from the Baylor College of Medicine and the University of Cincinnati.


Previous research has shown that AS model mice display brain dysfunctions that match neurological abnormalities observed in humans, including cognitive deficits such as long-term memory. A previous study by Klann and his colleagues pointed to a potential cause for the condition—overexpression of a subunit of a protein termed Na/K-ATPase in AS model mice.
In the Cell Reports study, the authors hypothesized that if they could decrease expression of this subunit, they could improve cognitive function of AS model mice.


To do this, they ran different populations of mice through cognitive and memory tests—including a water maze to examine spatial memory and a fear conditioning paradigm to examine associative memory.


In both experiments, the AS model mice with diminished expression of the Na/K-ATPase subunit showed recall abilities on par with normal mice. By contrast, other AS model mice exhibited diminished recall abilities, pointing the role this protein may play in AS-like impairments.
The research was supported by grants from the National Institutes of Health and by the Angelman Syndrome Foundation.

Type: Article

Neuroscientists Find Protein Linked to Cognitive Deficits in Angelman Syndrome

Search News



NYU In the News

NYU Received a Record Number of Applications

Capital New York reported NYU received a record 60,322 applications for the class of 2019, an increase of about 15 percent since last year.

NYU Students Help City Crack Down on Hookah Bars

Capital New York reported that NYU students helped New York City crack down on hookah bars that illegally include tobacco in their hookahs:

Rudin Center Study Says Mass Transit Helps Economic Mobility

The Wall Street Journal wrote about a report by Wagner’s Rudin Center that showed that mass transit could be more important than education in determining economic mobility.

Brennan Center Report Says Campaign Spending Has Jumped

Frontline did a piece about a report by the Brennan Center for Justice that said that campaign spending by outside groups has more than doubled in the last five years.

NYU’s Dorms Ranked Among the Best in the Nation

Hometalk.com ranked NYU’s student residences third in the country in its list of best college dorms.

 


NYU Footer