New York University Skip to Content Skip to Search Skip to Navigation Skip to Sub Navigation

Nanofiber Breakthrough Holds Promise for Medicine and Microprocessors

April 13, 2012

A new method for creating nanofibers made of proteins, developed by researchers at the Polytechnic Institute of New York University (NYU-Poly), promises to greatly improve drug delivery methods for the treatment of cancers, heart disorders, and Alzheimer’s disease, as well as aid in the regeneration of human tissue, bone, and cartilage.

Applied differently, this same development could also point the way to even tinier and more powerful microprocessors for future generations of computers and consumer electronics devices.

The research is detailed in an article titled “Effects of Divalent Metals on Nanoscopic Fiber Formation and Small Molecule Recognition of Helical Proteins,” which appears online in Advanced Functional Materials. Author Susheel K. Gunasekar, a doctoral student in NYU-Poly’s Department of Chemical and Biological Sciences, was the primary researcher, and is a student of co-author Jin Montclare, assistant professor and head of the department’s Protein Engineering and Molecular Design Lab, where the underlying research was primarily conducted. Also involved were co-authors Luona Anjia, a graduate student, and professor Hiroshi Matsui, both of the Department of Chemistry and Biochemistry at Hunter College, where secondary research was conducted.

Yet all of this almost never emerged, says Montclare, who explains that it was sheer “serendipity”—a chance observation made by Gunasekar two years ago—that inspired the team’s research.

During an experiment that involved studying certain cylinder-shaped proteins derived from cartilage oligomeric matrix protein (COMP, found predominantly in human cartilage), Gunasekar noticed that in high concentrations, these alpha helical coiled-coil proteins spontaneously self-assembled into nanofibers. It was a surprising outcome, Montclare says, because COMP was not known to form fibers at all.

“We were really excited,” Montclare recalls. “So we decided to do a series of experiments to see if we could control the fiber formation, and also control its binding to small molecules, which would be housed within the protein’s cylinder.”

Of special interest were molecules of curcumin, an ingredient in dietary supplements used to combat Alzheimer’s disease, cancers, and heart disorders.

By adding a set of metal-recognizing amino acids to the coiled-coil protein, the NYU-Poly team succeeded, finding that the nanofibers alter their shapes upon addition of metals such as zinc and nickel to the protein. Moreover, the addition of zinc fortified the nanofibers, enabling them to hold more curcumin, while the addition of nickel transformed the fibers into clumped mats, triggering the release of the drug molecule.

Next, Montclare says, the researchers plan to experiment with creating scaffolds of nanofibers that can be used to induce the regeneration of bone and cartilage (via embedded vitamin D) or human stem cells (via embedded vitamin A). It may even be possible to apply this organic, protein-based method for creating nanofibers to the world of computers and consumer electronics, Montclare says—producing nanoscale gold threads for use as circuits in computer chips by first creating the nanofibers and then guiding that metal to them.

Funding for this NYU-Poly research was provided by the U.S. Air Force Office of Scientific Research, the U.S. Army Research Office, the
U.S. Department of Energy, and the National Science Foundation.

Type: Article

Nanofiber Breakthrough Holds Promise for Medicine and Microprocessors

Search News



NYU In the News

Entrepreneurship Lab Opens at NYU

Crain’s New York Business covered the opening of the Mark and Debra Leslie Entrepreneurial eLab, which will be the headquarters for NYU’s Entrepreneurial Institute and all of the University’s programs aimed at promoting innovation and startups.

A Globalizer for N.Y.U. in Abu Dhabi

The New York Times profiled Bill Bragin who will become the first executive artistic director of NYU Abu Dhabi’s new performing arts center.

Think Tank to Ponder a Future for Ballet

The New York Times profiled Jennifer Homans, the director of NYU’s new Center for Ballet and the Arts.

The Brilliant Ten: Jonathan Viventi Builds Devices That Decode Thoughts

Popular Science named Assistant Bioengineering Professor Jonathan Viventi as one of its “brilliant ten” for his research into brain implants that could one day halt epileptic episodes:

Living and Leaving the Dream: Adrian Cardenas’ Journey from the Major Leagues to College

The New York Times ran a feature on Adrian Cardenas, a former major league baseball player who is now studying philosophy and creating writing at NYU.

NYU Footer