New York University Skip to Content Skip to Search Skip to Navigation Skip to Sub Navigation

NYU College of Dentistry Professor Awarded NYU School of Medicine Grant for Bladder Cancer Research

October 21, 2009
N-99, 2009-10

The NYU School of Medicine has awarded a one-year Center of Excellence grant to an NYU College of Dentistry professor to study how bladder tumors progress to invasive cancer.

Bladder cancer is the fourth most common cancer in men, and the eighth most common in women, with over 50,000 new cases and 14,000 bladder cancer-related deaths reported annually in the United States. Molecules found in tobacco smoke, processed meats, and rubber products have been linked to bladder cancer, and the new study, led by Dr. Joseph Guttenplan, a Professor of Basic Science and Craniofacial Biology at the College of Dentistry, will focus on one such molecule, known as BBN, or N-butyl- N-(4-hydroxybutyl) nitrosamine.

Dr. Guttenplan will investigate how BBN damages the DNA of mice to create mutations leading to cancer. He will also examine whether certain enzymes increase BBN’s toxicity to determine why some mice develop mutations and others do not. His findings could aid in the development of genetic tests to identify those individuals at a high risk for bladder cancer and also contribute to the development of new drugs or dietary supplements to prevent the disease. Dr. Guttenplan’s laboratory is one of only a handful of laboratories in the U.S. that can analyze and measure mutations in mouse organs. Dr. Guttenplan also uses mouse mutation analysis for oral cancer research.

NYU’s Senior Vice Provost for Research, Dr. Pierre Hohenberg, provided supplemental funding for the study. Dr. Xue-Ru Wu, Co-Director of the Center of Excellence on Urologic Disease at the NYU School of Medicine, is a coinvestigator on the grant.


About New York University College of Dentistry Founded in 1865, New York University College of Dentistry (NYUCD) is the third oldest and the largest dental school in the US, educating more than 8 percent of all dentists. NYUCD has a significant global reach and provides a level of national and international diversity among its students that is unmatched by any other dental school.

This Press Release is in the following Topics:
Research, College of Dentistry

Type: Press Release

Press Contact: Christopher James | (212) 998-6876

Dr. Joseph Guttenplan

Dr. Joseph Guttenplan


Search News



NYU In the News

Entrepreneurship Lab Opens at NYU

Crain’s New York Business covered the opening of the Mark and Debra Leslie Entrepreneurial eLab, which will be the headquarters for NYU’s Entrepreneurial Institute and all of the University’s programs aimed at promoting innovation and startups.

A Globalizer for N.Y.U. in Abu Dhabi

The New York Times profiled Bill Bragin who will become the first executive artistic director of NYU Abu Dhabi’s new performing arts center.

Think Tank to Ponder a Future for Ballet

The New York Times profiled Jennifer Homans, the director of NYU’s new Center for Ballet and the Arts.

The Brilliant Ten: Jonathan Viventi Builds Devices That Decode Thoughts

Popular Science named Assistant Bioengineering Professor Jonathan Viventi as one of its “brilliant ten” for his research into brain implants that could one day halt epileptic episodes:

Living and Leaving the Dream: Adrian Cardenas’ Journey from the Major Leagues to College

The New York Times ran a feature on Adrian Cardenas, a former major league baseball player who is now studying philosophy and creating writing at NYU.

NYU Footer